Long-Acting Injectable Antipsychotics for Schizophrenia

McCreath, James; Larson, Essie; Bharatiya, Purabi; Labanieh, Hisham A.; Weiss, Zvi; Lozovatsky, Michael

doi:10.4088/pcc.16m02005

Cited by 10 publications

(8 citation statements)

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“…The most commonly prescribed medications were paliperidone palmitate (31%), aripiprazole LAI (25%) and haloperidol decanoate (20%). These results are in line with data from some of the previous studies [ 42 , 74 , 75 ], while, in others, prescription rates appeared to be extremely heterogeneous [ 40 , 41 , 44 ]. This is likely to be associated with a number of factors influencing local prescribing patterns and with the different recruitment periods across studies (and therefore different availability of SGA LAIs).…”

Section: Discussionsupporting

confidence: 91%

Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy

et al. 2018

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BackgroundFor many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy.MethodsThe STAR Network “Depot” Study is an observational, longitudinal, multicenter study involving 35 centers in Italy. In the cross-sectional phase, patients prescribed with LAIs were consecutively recruited and assessed over a period of 12 months. Descriptive statistics and multivariable logistic regression analyses were employed.ResultsOf the 451 recruited patients, 61% were males. The level of social and working functioning was heterogeneous, as was the severity of disease. Seventy-two per cent of the patients had a diagnosis of the schizophrenia spectrum. Seventy per cent were prescribed with second-generation antipsychotic (SGA) LAIs (mostly paliperidone, aripiprazole and risperidone). Compared to first-generation antipsychotic (FGA) LAIs, patients prescribed with SGA LAIs were more often younger; employed; with a diagnosis of the schizophrenia spectrum or bipolar disorder; with higher levels of affective symptoms; with fewer LAI prescriptions in the past.DiscussionLAIs’ prescribing practices appear to be more flexible as compared to the past, although this change is mostly restricted to SGA LAIs.

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Section: Discussionsupporting

confidence: 91%

Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy

et al. 2018

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“…Nevertheless, it is difficult to interpret our data in the light of available literature, considering that most studies do not focus on people who are incarcerated (Llorca et al ., 2018) and differences in local clinical practice could impact on prescriptional attitudes (Ostuzzi et al ., 2018). Indeed, the discrepancy in patterns of prescription could be explained by differences in refundability and socio-economic context, or by the progressive introduction of depot formulation for SGAs (McCreath et al ., 2017). In the context of these considerations, some pragmatic aspects can be listed to explain the large use of FGA-LAIs in our sample.…”

Section: Discussionmentioning

confidence: 99%

Sociodemographic and clinical factors associated with prescription of first- versus second-generation long-acting antipsychotics in incarcerated adult males

Capuzzi,

Di Forti,

Caldiroli

et al. 2023

International Clinical Psychopharmacology

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Information on patterns of prescription of long-acting injection (LAI) antipsychotics among people who are incarcerated is lacking. Therefore, we aimed to evaluate prescribing rates for first-generation antipsychotic (FGA)-LAI versus second-generation antipsychotic (SGA)-LAI and to identify the factors associated with the prescription of one of the two classes of LAI. A cross-sectional study was conducted among incarcerated adult males hosted in Monza detention center between January 2013 and April 2023. Socio-demographic and clinical data were retrospectively collected. Descriptive and univariate statistics as well as logistic regression analyses were performed. Data were available for 135 consecutive incarcerated adult males with different mental disorders who received a LAI as part of their treatment. 75.6% of our sample was treated with FGA-LAIs, with haloperidol as the most commonly prescribed drug, followed by zuclopentixol and aripiprazole. Diagnosis of bipolar disorder and concomitant administration of antidepressants were statistically significant predictors of SGA-LAI prescription. Some patients’ characteristics may influence prescription patterns in prison. Further longitudinal studies with larger samples should confirm these findings.

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“…Many studies have shown that long-acting injectable antipsychotics are associated with better treatment compliance [47][48][49][50]. In light of this information, it can be argued that long-acting antipsychotic treatment may decrease care burden by increasing treatment compliance.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Long-acting Antipsychotic Treatment on the Level on Care Burden in Schizophrenia Patients

Eö¹,

Özpolat²

2021

Preprint

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Background: Most patients with schizophrenia are unable to fulfill their personal and social responsibilities and these are met by their caregivers. The concept of 'burden' has come to the fore for caregivers. Long-acting injectables have been shown to reduce relapse rates, and provide a better level of functionality, but their effect on caregiver burden has not been investigated. Objective: Our aim in this study is to investigate the effect of transition from oral to long-acting antipsychotic treatments on caregiver burden. Other factors that may be related to the burden were also discussed.Setting: This study was performed at Community Mental Health Center of Erzurum Regional Training and Research Hospital.Methods: Caregivers (n:138) of patients diagnosed with schizophrenia for at least one year and who received oral paliperidone or aripiprazole were evaluated at baseline and 1 year after switching to long-acting injectables.Main outcome measure: The Zarit Caregiver Burden Scale (ZCBS) and the Clinical Global Impression-Disease Severity (CGI-S) were administered. Demographic characteristics of caregivers and patients were evaluated.Results: Significant decreases were found in the ZCBS and CGI-S scores after transitioning to long-acting injectable antipsychotics (p <0.001). Caregiver burden was positively correlated with patient's age, CGI-S score, time spent in the same house, duration of illness, and the number of hospitalizations. A significant negative correlation was found among the caregiver’s age, educational level, and income (p <0.05).Conclusion: In the present study, the importance of switching to long-acting injectable antipsychotics, which is a modifiable factor, to reduce caregiver burden was emphasized

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Long-Acting Injectable Antipsychotics for Schizophrenia

Abstract: The findings of the current research suggest that medication type, frequency of medication appointments, and program type may be key in increasing and maintaining LAI adherence.

Cited by 10 publications

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Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy

Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy

Sociodemographic and clinical factors associated with prescription of first- versus second-generation long-acting antipsychotics in incarcerated adult males

The Effect of Long-acting Antipsychotic Treatment on the Level on Care Burden in Schizophrenia Patients

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