Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan

Yan, Sheng; Liu, Changsheng; Yuan, Yuan; Tao, Xinyi; Yang, Fan; Shan, Xiaoqian; Zhou, Hao; Xu, Feng

doi:10.1016/j.biomaterials.2008.12.070

Cited by 200 publications

(104 citation statements)

References 39 publications

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“…The small size and hydrophilic polyethylene glycol shell may also allow SH-ASA/Cur mPEG-PLGA-coloaded nanoparticles to circulate for a long time in vivo. 55,56 Thus, our results suggested that this SH-ASA/Cur mPEG-PLGAcoloaded nanoparticle is a good aqueous formulation for combination therapy.…”

mentioning

confidence: 72%

Codelivery of SH-aspirin and curcumin by mPEG-PLGA nanoparticles enhanced antitumor activity by inducing mitochondrial apoptosis

Zhou¹,

Duan²,

Zeng³

et al. 2015

IJN

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Natural product curcumin (Cur) and H 2 S-releasing prodrug SH-aspirin (SH-ASA) are potential anticancer agents with diverse mechanisms, but their clinical application prospects are restricted by hydrophobicity and limited efficiency. In this work, we coencapsulated SH-ASA and Cur into methoxy poly(ethylene glycol)-poly (lactide-coglycolide) (mPEG-PLGA) nanoparticles through a modified oil-in-water single-emulsion solvent evaporation process. The prepared SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles had a mean particle size of 122.3±6.8 nm and were monodispersed (polydispersity index =0.179±0.016) in water, with high drug-loading capacity and stability. Intriguingly, by treating with SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles, obvious synergistic anticancer effects on ES-2 and SKOV3 human ovarian carcinoma cells were observed in vitro, and activation of the mitochondrial apoptosis pathway was indicated. Our results demonstrated that SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles could have potential clinical advantages for the treatment of ovarian cancer.

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mentioning

confidence: 72%

Codelivery of SH-aspirin and curcumin by mPEG-PLGA nanoparticles enhanced antitumor activity by inducing mitochondrial apoptosis

Zhou¹,

Duan²,

Zeng³

et al. 2015

IJN

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“…[12][13][14][15] Although PEGylation has been demonstrated to be useful for preventing aggregation of nanoparticles in physiologic conditions, obtaining a sufficient PEG density on the nanoparticle surface to prevent blood opsonization may be limited by the weak affinity of anchor groups. 16,17 Other surface functionalizations, such as conjugation of targeting moieties or crosslinking payload materials, may also interfere with PEGylation.…”

mentioning

confidence: 99%

Anti-HER2 antibody and ScFvEGFR-conjugated antifouling magnetic iron oxide nanoparticles for targeting and magnetic resonance imaging of breast cancer

Chen¹,

Wang²,

Yu³

et al. 2013

IJN

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“…Addition of a PEG layer shifts the biodistribution towards the spleen (Owens and Peppas, 2006). To further increase the blood circulation time and reduce cytotoxicity, some authors combined PEG with chitosan in the particle coatings (Sheng et al , 2009). Interestingly, particles with diameter >200 nm show a more rapid clearance than smaller particles, regardless whether they have a PEG coating or not.…”

Section: Biodistribution and Biocompatibilitymentioning

confidence: 99%

Polymeric nanoparticles for optical sensing

Canfarotta

Whitcombe

Piletsky

2013

Biotechnology Advances

121

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Nanotechnology is a powerful tool for use in diagnostic applications. For these purposes a variety of functional nanoparticles containing fluorescent labels, gold and quantum dots at their cores have been produced, with the aim of enhanced sensitivity and multiplexing capabilities. This work will review progress in the application of polymeric nanoparticles in optical diagnostics, both for in vitro and in vivo detection, together with a discussion of their biodistribution and biocompatibility.

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Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan

Cited by 200 publications

References 39 publications

Codelivery of SH-aspirin and curcumin by mPEG-PLGA nanoparticles enhanced antitumor activity by inducing mitochondrial apoptosis

Codelivery of SH-aspirin and curcumin by mPEG-PLGA nanoparticles enhanced antitumor activity by inducing mitochondrial apoptosis

Anti-HER2 antibody and ScFvEGFR-conjugated antifouling magnetic iron oxide nanoparticles for targeting and magnetic resonance imaging of breast cancer

Polymeric nanoparticles for optical sensing

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