Long COVID-19

Rodríguez-Sánchez, Isabel; Rodríguez‐Mañas, Leocadio; Laosa, Olga

doi:10.1016/j.cger.2022.03.005

Cited by 25 publications

(17 citation statements)

References 63 publications

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“…This multidisciplinary approach using pre-defined clinical criteria may optimize cost-effectiveness by triaging patients directly to the appropriate specialists. A significant body of work has emerged commenting on interdisciplinary rather than multidisciplinary care for long COVID 18 , 19 . These studies emphasize the challenges in coordination of care and clarifying appropriate dynamic between specialties in long COVID care 20 .…”

Section: Discussionmentioning

confidence: 99%

Multidisciplinary Center Care for Long COVID Syndrome–A Retrospective Cohort Study

Bailey

Lavelle

Miller

et al. 2025

The American Journal of Medicine

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Section: Discussionmentioning

confidence: 99%

Multidisciplinary Center Care for Long COVID Syndrome–A Retrospective Cohort Study

Bailey

Lavelle

Miller

et al. 2025

The American Journal of Medicine

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“…(2) Moreover, the large number of individuals requiring continued medical care will pose an economic burden on our health care system. (10)…”

Section: Introductionmentioning

confidence: 99%

“…There is also uncertainty in the pathophysiology and symptomatology of long COVID. (9,10) With the elevated burden of COVID-19 worldwide, it is important to understand the full range of symptoms and long-term outcomes. (2) Moreover, the large number of individuals requiring continued medical care will pose an economic burden on our health care system.…”

Section: Introductionmentioning

confidence: 99%

Cohort profile: the Johns Hopkins COVID Long Study (JHCLS), a United States Nationwide Prospective Cohort Study

Wentz,

Ni,

Yenokyan

et al. 2024

Preprint

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PurposeCOVID-19 disease continues to affect millions of individuals worldwide, both in the short and long term. The post-acute complications of SARS-CoV-2 infection, referred to as long COVID, result in diverse symptoms affecting multiple organ systems. Little is known regarding how the symptoms associated with long COVID progress and resolve over time. The Johns Hopkins COVID Long Study aims to prospectively examine the short- and long-term consequences of COVID-19 disease in individuals both with and without a history of SARS-CoV-2 infection using self-reported data collected in an online survey.ParticipantsSixteen thousand, seven hundred sixty-four adults with a history of SARS-CoV-2 infection and 799 adults without a history of SARS-CoV-2 infection who completed an online baseline survey.Findings to dateThis cohort profile describes the baseline characteristics of the Johns Hopkins COVID Long Study. Among 16,764 participants with a history of SARS-CoV-2 infection and defined long COVID status, 75% reported a good or excellent health status prior to infection, 99% reported experiencing at least one COVID-19 symptom during the acute phase of infection, 9.9% reported a hospitalization, and 63% were defined as having long COVID using the WHO definition.Future plansAnalysis of longitudinal data will be used to investigate the progression and resolution of long COVID symptoms over time.

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“…Although the respiratory tract is the site of entry and infection of SARS-CoV-2, COVID-19 is a complex disease, affecting the cardiovascular, renal, hematological, gastrointestinal, and central nervous systems, and can present a wide severity spectrum, from asymptomatic to severe, moderate or mild symptoms. The occurrence of acute COVID-19 last from 1-2 weeks in mild cases and up to 12 weeks for the most severe ones, based on factors such as age, symptoms, comorbidities, vaccination status, access to treatment and medical services ( 3 ). More than half of the infected individuals are presented with persistent symptoms even longer than four weeks after the onset of first clinical signs, a condition defined as post-acute sequelae of COVID-19 (PASC).…”

Section: Introductionmentioning

confidence: 99%

The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches

Gheorghita,

Soldanescu,

Lobiuc

et al. 2024

Front. Immunol.

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The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been defined as the greatest global health and socioeconomic crisis of modern times. While most people recover after being infected with the virus, a significant proportion of them continue to experience health issues weeks, months and even years after acute infection with SARS-CoV-2. This persistence of clinical symptoms in infected individuals for at least three months after the onset of the disease or the emergence of new symptoms lasting more than two months, without any other explanation and alternative diagnosis have been named long COVID, long-haul COVID, post-COVID-19 conditions, chronic COVID, or post-acute sequelae of SARS-CoV-2 (PASC). Long COVID has been characterized as a constellation of symptoms and disorders that vary widely in their manifestations. Further, the mechanisms underlying long COVID are not fully understood, which hamper efficient treatment options. This review describes predictors and the most common symptoms related to long COVID’s effects on the central and peripheral nervous system and other organs and tissues. Furthermore, the transcriptional markers, molecular signaling pathways and risk factors for long COVID, such as sex, age, pre-existing condition, hospitalization during acute phase of COVID-19, vaccination, and lifestyle are presented. Finally, recommendations for patient rehabilitation and disease management, as well as alternative therapeutical approaches to long COVID sequelae are discussed. Understanding the complexity of this disease, its symptoms across multiple organ systems and overlapping pathologies and its possible mechanisms are paramount in developing diagnostic tools and treatments.

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Long COVID-19

Cited by 25 publications

References 63 publications

Multidisciplinary Center Care for Long COVID Syndrome–A Retrospective Cohort Study

Multidisciplinary Center Care for Long COVID Syndrome–A Retrospective Cohort Study

Cohort profile: the Johns Hopkins COVID Long Study (JHCLS), a United States Nationwide Prospective Cohort Study

The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches

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