‘Long COVID’: persistent COVID-19 symptoms in survivors managed in Lagos State, Nigeria

Osikomaiya, Bodunrin; Erinoso, Olufemi; Wright, Kikelomo Ololade; Odusola, Aina Olufemi; Thomas, Babafemi; Adeyemi, Oluwatosin; Bowale, Abimbola; Adejumo, Olusola Adedeji; Falana, Ayodeji; Abdus-Salam, Ismail; Ogboye, Olusegun; Osibogun, Akin; Abayomi, Akin

doi:10.1186/s12879-020-05716-x

Cited by 84 publications

(164 citation statements)

References 29 publications

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“…Among the 354 patients included in our cohort study, 36% of patients reported the presence of one or more symptoms after at least 9 months (in the mean) after COVID-19 onset. The most common symptoms were fatigue, dyspnea, and pain symptoms, which is consistent with the literature thus far [ 1 , 2 , 3 , 4 , 11 , 12 , 16 ]. These findings suggested systemic chronic inflammation with abnormal pro-inflammatory cytokine expression, which was observed in patients following COVID-19 [ 17 ].…”

Section: Discussionsupporting

confidence: 91%

“…Recently, there have been several reports of patients who reported no return to their previous state of health after having COVID-19 for several weeks or months, with variation in the duration of symptoms and clinical history [ 3 ]. Some authors referred to ‘long COVID-19 syndrome’ [ 2 , 4 , 5 , 6 ], ‘post-COVID-19 syndrome’ [ 7 , 8 ], or ‘post-acute COVID-19 syndrome’ [ 3 , 9 ], a syndrome that can possibly have an impact on the quality of life of patients [ 10 ]. The most common persistent symptoms in COVID-19 are fatigue and breathlessness [ 8 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…The most common persistent symptoms in COVID-19 are fatigue and breathlessness [ 8 , 11 , 12 ]. Neurological symptoms, such as headaches [ 4 , 5 , 8 , 11 , 12 ]; otorhinolaryngological symptoms [ 11 , 13 ], such as olfactory and gustatory dysfunctions; psychiatric symptoms, such as concentration problems, sleep difficulties, and anxiety [ 11 , 14 ] are also common long-term consequences of COVID-19. Although considerable progress has been made in treating COVID-19, very little is known about the long-term consequences of this infection.…”

Section: Introductionmentioning

confidence: 99%

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Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France

et al. 2021

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(1) Background. Post-COVID-19 syndrome is defined as the persistence of symptoms after confirmed SARS-CoV-2 infection. (2) Methods. ANOSVID is an observational retrospective study in Nord Franche-Comté Hospital in France that included adult COVID-19 patients confirmed by RT-PCR from 1 March 2020 to 31 May 2020. The aim was to describe patients with post-COVID-19 syndrome with persistent symptoms (PS group) and to compare them with the patients without persistent symptoms (no-PS group). (3) Results. Of the 354 COVID-19 patients, 35.9% (n = 127) reported persistence of at least one symptom after a mean of 289.1 ± 24.5 days after symptom onset. Moreover, 115 patients reported a recurrence of symptoms after recovery, and only 12 patients reported continuous symptoms. The mean age of patients was 48.6 years (19–93) ± 19.4, and 81 patients (63.8%) were female. Patients in the PS group had a longer duration of symptoms of initial acute SARS-CoV-2 infection than patients in the no-PS group (respectively, 57.1 ± 82.1 days versus 29.7 ± 42.1 days, p < 0.001). A majority of patients (n = 104, 81.9%) reported three or more symptoms. The most prevalent persistent symptoms were loss of smell (74.0%, n = 94), fatigue (53.5%, n = 68), loss of taste (31.5%, n = 40), and dyspnea (30.7%, n = 39). These were followed by pain symptoms (26.8% (n = 34), 26.0% (n = 33), 24.4% (n = 31); headache, arthralgia, and myalgia, respectively). More than half of patients reporting persistent symptoms (58%, n = 73) were healthcare workers (HCWs). Among outpatients, this population was more present in the PS group than the no-PS group ((86.6%) n = 71/82 versus (72.2%) n = 109/151, p = 0.012). Post-COVID-19 syndrome was more frequent in patients with a past history of chronic rhinosinusitis (8.7% (n = 11%) versus 1.3% (n = 3), p < 0.001). No significant difference was found regarding clinical characteristics and outcome, laboratory, imaging findings, and treatment received in the two groups. (4) Conclusions. More than a third of our COVID-19 patients presented persistent symptoms after SARS-CoV-2 infection, particularly through loss of smell, loss of taste, fatigue, and dyspnea, with a high prevalence in HCWs among COVID-19 outpatients.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France

et al. 2021

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“…The studies in the literature investigating post‐COVID symptoms were usually performed in the early period after recovery or in a relatively small number of patients. 3 , 4 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 There is growing concern regarding post‐COVID syndrome, but still little is known. Understanding the prevalence, variety, and duration of the post‐COVID manifestations that are not usually life‐threatening but impair the quality of life, is crucial for the development of follow‐up and treatment strategies in the post‐COVID periods.…”

Section: Discussionmentioning

confidence: 99%

Post‐COVID syndrome: A single‐center questionnaire study on 1007 participants recovered from COVID‐19

Kayaaslan

Eser

Kalem

et al. 2021

Journal of Medical Virology

115

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Post recovery manifestations have become another concern in patients who have recovered from coronavirus disease 2019 (COVID‐19). Numerous reports have shown that COVID‐19 has a variety of long‐term effects on almost all systems including respiratory, cardiovascular, gastrointestinal, neurological, psychiatric, and dermatological systems. We aimed to investigate the prevalence and characteristics of the post‐COVID syndrome among COVID‐19 survivors and to determine the factors associated with persistent symptoms. This prospective study enrolled in patients with COVID‐19 followed in hospital or outpatient clinics in Ankara City Hospital. We performed a special questionnaire to inquire about the presence of persistent symptoms beyond 12 weeks from the first diagnosis. Demographic data, comorbid diseases, characteristics of acute COVID‐19, presence of persistent symptoms by systems, and knowledge about outpatient clinic visits after recovery were assessed. Of a total of 1007 participants, 39.0% had at least one comorbidity, and 47.5% had persistent symptoms. Fatigue/easy fatigability, myalgia, and loss of weight were the most frequent persistent symptoms (overall 29.3%) followed by respiratory symptoms (25.4%). A total of 235 participants had visited outpatient clinics due to several reasons during the post‐COVID‐19 period, and 17 of them were hospitalized. Severe acute COVID‐19, hospitalization, and presence of comorbidity were independent factors for the development of persistent symptoms. Fully understanding the spectrum of the post‐COVID syndrome is essential for appropriate management of all its long‐term effects. Our study once again underlined the fact that the prevalence of post‐COVID syndrome is higher than expected and concerns many systems, and a multidisciplinary follow‐up should be provided to COVID‐19 survivors in the post recovery period.

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“…This assertion is corroborated by a similar study from Lagos, Nigeria, where 40.6% of hospitalized adults reported symptoms suggestive of PCS. 10 Studies from Europe, the United Kingdom, the United States, and Asia have reported PCS among 32% to 96% of hospitalized COVID-19 patients. [12][13][14][15] Cough, fatigue, and dyspnea were the most common symptoms reported in our cohort.…”

Section: Discussionmentioning

confidence: 99%

Post-Discharge Symptoms among Hospitalized COVID-19 Patients in Nigeria: A Single-Center Study

Ogoina

James

Ogoinja

2021

The American Journal of Tropical Medicine and Hygiene

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There is a paucity of studies on post-acute COVID-19 syndrome (PCS) among hospitalized COVID-19 survivors from Nigeria. We describe the frequency, types, and duration of post-discharge symptoms suggestive of PCS among previously hospitalized COVID-19 patients in a treatment center in Nigeria. We conducted a retrospective review of admission and post-discharge follow-up medical records of COVID-19 survivors admitted between April and December 2020. A standardized checklist was used to document post-discharge symptoms. PCS was defined as persisting or new post-discharge symptoms lasting at least 3 weeks after initial COVID-19 symptoms. The relationship between study variables and development of PCS was ascertained by univariate analysis. Thirty of 51 previously hospitalized COVID-19 patients (median age, 46 years; male, 66.7%) were studied. Seventeen (56.7%) of the 30 patients developed features suggestive of PCS. Approximately three post-discharge symptoms were reported per patient over a follow-up period of ranging from 3 weeks to 9 months after initial COVID-19 symptoms. Cough, fatigue, and dyspnea were the most common post-discharge symptoms reported. A few patients had symptoms suggestive of thrombosis and COVID-19 reinfection. Among all study variables, baseline COVID-19 severity was the only significant variable associated with the development of PCS. PCS is common in our setting and is characterized by multisystemic signs and symptoms that require vigilance by clinicians for appropriate diagnosis and treatment. Long-term multicenter prospective studies are needed to characterize fully the burden of PCS among COVID-19 survivors in Nigeria.

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‘Long COVID’: persistent COVID-19 symptoms in survivors managed in Lagos State, Nigeria

Cited by 84 publications

References 29 publications

Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France

Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France

Post‐COVID syndrome: A single‐center questionnaire study on 1007 participants recovered from COVID‐19

Post-Discharge Symptoms among Hospitalized COVID-19 Patients in Nigeria: A Single-Center Study

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