Long Eyelashes in a Case Series of 93 Children With Vernal Keratoconjunctivitis

Abstract

ABSTRACT. Objective. Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis that affects children mainly in temperate areas, with exacerbations in spring and summer. Eyelashes provide natural protection for the eyes from sunshine, wind, and foreign bodies. These factors induce a worsening of signs and symptoms in VKC, whereas mechanical protection of the eyes produces relief. The aim of this study was to evaluate eyelash length in a large series of VKC patients and in ageand gender-matched healthy subjects.Methods. Upper eyelash length was measured in 93 VKC patients (mean age: 8.7 years; range: 4 -18 years) with a digital caliper. History, clinical form, type of presentation, degree of severity, and drug therapy were evaluated. Skin tests and serum-specific immunoglobulin E for common allergens, serum-total immunoglobulin E, peripheral blood eosinophil counts, and serum eosinophil cationic protein were determined. Two age-and gender-matched control subjects for each VKC patient underwent the same eyelash measurement.Results. The upper eyelashes were significantly longer in VKC patients than in control subjects (mean ؎ SD: 8.9 ؎ 1.17 mm vs 7.9 ؎ 1.07 mm). In healthy subjects, a negative correlation was found between eyelash length and age. With multivariate analysis, unlike control subjects, the eyelash length in VKC patients did not correlate with age, was positively correlated with the degree of severity of VKC, and was negatively correlated with the use of topical cyclosporine.Conclusions. Patients with VKC had longer eyelashes than healthy matched subjects. ABBREVIATIONS. VKC, vernal keratoconjunctivitis; bFGF, basic fibroblast growth factor; s-P, substance P; IgE, immunoglobulin E; s-ECP, serum eosinophil cationic protein; PBEC, peripheral blood eosinophil count.

Eyelash trichomegaly following treatment with erlotinib in a non-small cell lung cancer patient: A case report and literature review

“…This condition was initially identified in patients with certain congenital syndromes, including the Oliver-McFarlane syndrome (8), Cornelia de Lange syndrome (9) or familial hypertrichosis (10). Acquired trichomegaly is also associated with specific drugs (11,12) and other diseases, including vernal keratoconjunctivitis and atopic dermatitis (13,14). However, eyelash trichomegaly is not a drug-limiting side effect.…”

Elements of morphology: Standard terminology for the periorbital region

“…subjective Comment: Measurement should be done on the longest lashes, which are usually at the center of the lid. Normal values are 7.99 AE 1.05 mm in boys and 7.76 AE 1.03 mm in girls [Pucci et al, 2005].…”

Eyelashes: Anatomical and Physiological Features, Eyelash Loss and Trichomegaly: Review

“…31 Trikomegaliye neden olabilen bir diğer oküler hastalık, bilateral allerjik konjonktivit varlığı ile karakterize vernal konjonktivittir. 24,32 Pucci ve ark., 93 hastayı ve 186 kontrolü dâhil ettikleri çalışma-larında, vernal konjonktivitli hastalarda üst kirpiklerin kontrole kıyasla anlamlı daha uzun olduğunu ve bunun oküler bulguların şiddeti ile korele olduğunu göstermişlerdir. 32 Trikomegali nedeninin oküler inflamasyon ve immün reaksiyonlar olabileceğini öne sürmüşlerdir.…”

“…24,32 Pucci ve ark., 93 hastayı ve 186 kontrolü dâhil ettikleri çalışma-larında, vernal konjonktivitli hastalarda üst kirpiklerin kontrole kıyasla anlamlı daha uzun olduğunu ve bunun oküler bulguların şiddeti ile korele olduğunu göstermişlerdir. 32 Trikomegali nedeninin oküler inflamasyon ve immün reaksiyonlar olabileceğini öne sürmüşlerdir. 32 Sistemik veya topikal ilaç kullanımı da trikomegaliye neden olabilmektedir.…”

“…32 Trikomegali nedeninin oküler inflamasyon ve immün reaksiyonlar olabileceğini öne sürmüşlerdir. 32 Sistemik veya topikal ilaç kullanımı da trikomegaliye neden olabilmektedir. Trikomegali ile birlikteliği daha sık bildirilen ilaçlar arasında EGFR inhibitörleri ve prostaglandin analogları yer almaktadır.…”