The gob-side roadway in an isolated island working face is a typical representative of a strong mining roadway, which seriously restricts the efficient and safe production of underground coal mines. With the engineering background of the main transportation roadway 1513 (MTR 1513) of the Xinyi Coal Mine, this paper introduces the engineering case of gob-side roadway driving with small coal-pillar facing mining in an isolated island working face under the alternate mining of wide and narrow working faces. Through comprehensive research methods, we studied zoning disturbance deformation characteristics and stress evolution law of gob-side roadway driving under face mining. Based on the characteristics of zoning disturbance, MTR 1513 is divided into three zones, which are the heading face mining zone, the mining influenced zone, and the mining stability zone. A collaborative control technology using pressure relief and anchoring is proposed, and the differentiated control method is formed for the three zones. For the heading face mining zone, the control method of anchoring first and then pressure relief is adopted; for the mining influenced zone, the control idea of synchronous coordination of pressure relief and anchorage is adopted; for the mining stability zone, the control method of anchoring without pressure relief is adopted. Engineering practices show that the disturbance influence distance of working face 1511 on MTR 1513 changes from 110 m advanced to 175 m delay. At this time, the surrounding rock deformation is effectively controlled, which verified the rationality of the division and the feasibility of three zoning control technology. The research results can provide reference for gob-side roadway driving with small coal pillar facing mining in a special isolated island working face.