2021
DOI: 10.3390/ijms222011242
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Long Intergenic Noncoding RNA OIN1 Promotes Ovarian Cancer Growth by Modulating Apoptosis-Related Gene Expression

Abstract: Patients with advanced ovarian cancer usually exhibit high mortality rates, thus more efficient therapeutic strategies are expected to be developed. Recent transcriptomic studies revealed that long intergenic noncoding RNAs (lincRNAs) can be a new class of molecular targets for cancer management, because lincRNAs likely exert tissue-specific activities compared with protein-coding genes or other noncoding RNAs. We here show that an unannotated lincRNA originated from chromosome 10q21 and designated as ovarian … Show more

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Cited by 7 publications
(7 citation statements)
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“…Increasing evidence demonstrated the functional and clinical role of lncRNAs involved in the progression ( 24 , 25 ). For instance, lincRNA OIN1 could act as a tumor oncogenic lincRNA in ovarian cancer, which will be a potential molecular target for treating ovarian cancer ( 26 ). Higher lncRNA ANRIL expression was related to increased metastases rates and reduced OS rate in osteosarcoma ( 27 ).…”
Section: Discussionmentioning
confidence: 99%
“…Increasing evidence demonstrated the functional and clinical role of lncRNAs involved in the progression ( 24 , 25 ). For instance, lincRNA OIN1 could act as a tumor oncogenic lincRNA in ovarian cancer, which will be a potential molecular target for treating ovarian cancer ( 26 ). Higher lncRNA ANRIL expression was related to increased metastases rates and reduced OS rate in osteosarcoma ( 27 ).…”
Section: Discussionmentioning
confidence: 99%
“…Accumulating evidence demonstrates the functional and clinical roles of lncRNAs involved in tumor progression [19][20][21]. For instance, lincRNA OIN1 is oncogenic in ovarian cancer and a potential molecular target for its treatment [22]. Higher lncRNA ANRIL expression is related to increased metastases rates and reduced overall survival rate in osteosarcoma [23].…”
Section: Discussionmentioning
confidence: 99%
“…After the discovery of the first lncRNAs in 1990 ( 15 ), lncRNAs have received increasing attention. Numerous lncRNAs participate in the pathogenesis of different diseases ( 16 ); these include lncRNA CDC6 in breast cancer ( 17 ), lncRNA OIN1 in ovarian cancer ( 18 ) and lncRNA RP11-567G11.1 in pancreatic cancer ( 19 ). Owing to the development of sequencing technology, lncRNAs have been found to serve an important role in tumour cell proliferation, apoptosis, differentiation and invasion ( 11 , 20 ).…”
Section: Role Of Lncrnas In Cancermentioning
confidence: 99%