Long non-coding RNA AC012668 suppresses non-alcoholic fatty liver disease by competing for microRNA miR-380-5p with lipoprotein-related protein LRP2

Chen, Xiaomeng; Ma, Hong; Gao, Yan; Jin, Yufeng; Wei, Ning; Hou, Yue; Su, Jianrong

doi:10.1080/21655979.2021.1960463

Cited by 12 publications

(4 citation statements)

References 37 publications

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“…AC012668 is located on chromosome 2. In a recent study, AC012668 was sharply downregulated in NAFLD 55 . AC012668 overexpression alleviated NAFLD through miR380‐5p/low‐density lipoprotein‐related protein‐2 (LRP2) axis.…”

Section: Lncrnas Involved In the Regulation Of Nafldmentioning

confidence: 97%

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The impact and role of identified long noncoding RNAs in nonalcoholic fatty liver disease: A narrative review

Shi

Sun

Tang

et al. 2023

Clinical Laboratory Analysis

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BackgroundNonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, but its mechanism and pathophysiology remain unclear. Long noncoding RNAs (lncRNAs) may exert a vital influence on regulating various biological functions in NAFLD.MethodsThe databases such as Google Scholar, PubMed, and Medline were searched using the following keywords: nonalcoholic fatty liver disease, nonalcoholic fatty liver disease, NAFLD, nonalcoholic steatohepatitis, nonalcoholic steatohepatitis, NASH, long noncoding RNAs, and lncRNAs. Considering the titles and abstracts, unrelated studies were excluded. The authors evaluated the full texts of the remaining studies.ResultsWe summarized the current knowledge of lncRNAs and the main signaling pathways of lncRNAs involved in NAFLD explored in recent years. As a heterogeneous group of noncoding RNAs (ncRNAs), lncRNAs play crucial roles in biological processes underlying the pathophysiology of NAFLD. The mechanisms, particularly those associated with the regulation of the expression and activities of lncRNAs, play important roles in NAFLD.ConclusionA better comprehension of the mechanism controlled by lncRNAs in NAFLD is necessary for the identification of novel therapeutic targets for drug development and improved, noninvasive methods for diagnosis.

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Section: Lncrnas Involved In the Regulation Of Nafldmentioning

confidence: 97%

“…In a recent study, AC012668 was sharply downregulated in NAFLD. 55 AC012668 overexpression alleviated NAFLD through miR380‐5p/low‐density lipoprotein‐related protein‐2 (LRP2) axis. As ceRNA, AC012668 inhibited miR‐380‐5p, thereby preventing its action toward the target LRP2.…”

Section: Lncrnas Involved In the Regulation Of Nafldmentioning

confidence: 99%

The impact and role of identified long noncoding RNAs in nonalcoholic fatty liver disease: A narrative review

Shi

Sun

Tang

et al. 2023

Clinical Laboratory Analysis

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“…In contrast, free fatty acid triggers apoptosis of liver LO2 cells associated with downregulating AC012668. Overexpression of AC012668, a lncRNA, downregulates SREBP1 expression [153]. Accordingly, the relationship between SREBP1 and apoptosis warrants a detailed investigation, especially for cancer cells.…”

Section: Akt Effector (Srebp1)-regulating Lncrnas and Cell Functionsmentioning

confidence: 99%

Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells

Tang

Chuang

Shiau

et al. 2022

Cells

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AKT serine-threonine kinase (AKT) and its effectors are essential for maintaining cell proliferation, apoptosis, autophagy, endoplasmic reticulum (ER) stress, mitochondrial morphogenesis (fission/fusion), ferroptosis, necroptosis, DNA damage response (damage and repair), senescence, and migration of cancer cells. Several lncRNAs and circRNAs also regulate the expression of these functions by numerous pathways. However, the impact on cell functions by lncRNAs and circRNAs regulating AKT and its effectors is poorly understood. This review provides comprehensive information about the relationship of lncRNAs and circRNAs with AKT on the cell functions of cancer cells. the roles of several lncRNAs and circRNAs acting on AKT effectors, such as FOXO, mTORC1/2, S6K1/2, 4EBP1, SREBP, and HIF are explored. To further validate the relationship between AKT, AKT effectors, lncRNAs, and circRNAs, more predicted AKT- and AKT effector-targeting lncRNAs and circRNAs were retrieved from the LncTarD and circBase databases. Consistently, using an in-depth literature survey, these AKT- and AKT effector-targeting database lncRNAs and circRNAs were related to cell functions. Therefore, some lncRNAs and circRNAs can regulate several cell functions through modulating AKT and AKT effectors. This review provides insights into a comprehensive network of AKT and AKT effectors connecting to lncRNAs and circRNAs in the regulation of cancer cell functions.

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“…Previous study has demonstrated the role of long non-coding RNA, miRNA, and mRNA in NAFLD. It is noted that proteomics is attracting more and more attention [ 22 ]. Proteomics is a science that explores the protein composition and changes of cells, tissues, and even organisms.…”

Section: Introductionmentioning

confidence: 99%

Quantitative proteomics analysis based on tandem mass tag labeling coupled with labeling coupled with liquid chromatography-tandem mass spectrometry discovers the effect of silibinin on non-alcoholic fatty liver disease in mice

et al. 2022

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In recent years, the beneficial effects of silibinin (SIL) on nonalcoholic fatty liver disease (NAFLD) have attracted widespread attention. We tried to study the intervention effect of SIL on NAFLD, and explore the potential mechanisms and targets of SIL on NAFLD improvement. Thirty-three male C57BL6/J mice were divided into three groups, and, respectively, fed a normal diet (ND), a high-fat diet (HFD) or a HFD given SIL treatment (HFD+SIL). Biochemical indexes and histopathological changes of mice in each group were detected. In addition, quantitative proteomics analysis based on tandem mass tag (TMT) labeling coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) and bioinformatics analysis was performed on protein changes in the livers. SIL could reduce the weight of mice, reduce liver lipid deposition, and improve glucose metabolism. Through comparison among the three experimental groups, a total of 30 overlapping proteins were found. These identified proteins were closely linked to liver lipid metabolism and energy homeostasis. Moreover, some drug targets were found, namely perilipin-2, phosphatidate phosphatase LPIN1, farnesyl pyrophosphate synthase, and glutathione S-transferase A1. In conclusions, high-fat diet increases the expressions of proteins implicated in lipid synthesis and transport in the liver, which can result in disorders of liver lipid metabolism. SIL can decrease liver lipid deposition and increase insulin sensitivity by regulating the expressions of these proteins. It not only improves the disorder of lipid metabolism in vivo, but also improves the disorder of glucose metabolism.

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Long non-coding RNA AC012668 suppresses non-alcoholic fatty liver disease by competing for microRNA miR-380-5p with lipoprotein-related protein LRP2

Cited by 12 publications

References 37 publications

The impact and role of identified long noncoding RNAs in nonalcoholic fatty liver disease: A narrative review

The impact and role of identified long noncoding RNAs in nonalcoholic fatty liver disease: A narrative review

Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells

Quantitative proteomics analysis based on tandem mass tag labeling coupled with labeling coupled with liquid chromatography-tandem mass spectrometry discovers the effect of silibinin on non-alcoholic fatty liver disease in mice

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