Long Non-Coding RNA BANCR Promotes Proliferation in Malignant Melanoma by Regulating MAPK Pathway Activation

Li, Ruiya; Zhang, Lingli; Jia, Lizhou; Duan, Yan; Li, Yan; Sha, Na

doi:10.1371/journal.pone.0100893

Cited by 147 publications

(143 citation statements)

References 34 publications

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“…They found that BANCR knockdown reduced melanoma cell migration. Li et al (2014) further reported that BANCR was overexpressed in human malignant melanoma cell lines and tissues and increased expression with tumor stage (Li et al, 2014). Knockdown of BANCR suppressed melanoma cell proliferation via regulation of the MAPK pathway.…”

Section: Discussionmentioning

confidence: 93%

Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma

Zq¹,

R-B²,

Dm³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Long noncoding RNAs (lncRNAs) play important roles in the formation and progression of many types of human malignancies. The aim of our study was to investigate the expression and biological functions of the lncRNA BRAF-activated noncoding RNA (BANCR) in human osteosarcoma. BANCR expression was quantified by real-time PCR in human osteosarcoma cell lines and tissues. We analyzed the association between BANCR levels and clinicopathological factors and patient prognosis. MTT, flow cytometric, and transwell invasion assays were performed to observe the effects of BANCR on MG-63 cell biological behaviors. BANCR overexpression was observed in osteosarcoma cell lines and clinical specimens. Increased BANCR expression was significantly associated with large tumor size, positive distant metastasis, and advanced clinical stage. High BANCR expression in osteosarcoma was an independent predictor of poor survival. Downregulation of BANCR inhibited MG-63 cell proliferation and invasion and promoted cell apoptosis in vitro. These findings suggested that BANCR may act as a tumor promoter in osteosarcoma and could serve as a potential therapeutic target for this disease.

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Section: Discussionmentioning

confidence: 93%

Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma

Zq¹,

R-B²,

Dm³

et al. 2016

Genet. Mol. Res.

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“…BANCR participates in the proliferation of malignant melanoma cells (7). BANCR regulates cellular proliferation and migration via p38 MAPK and c-Jun N-terminal kinase inactivation in lung carcinoma (LC) (8).…”

Section: Discussionmentioning

confidence: 99%

“…BRAF-activated non-protein coding RNA (BANCR) is a 693-bp-long transcript on chromosome 9. It is frequently overexpressed and may be involved in the migration of melanoma cells (7). In non-small cell lung cancer, BANCR promotes the migration and invasion of cancer cells (8) through the mitogen-activated protein kinase (MAPK) signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

lncRNA BANCR promotes EMT in PTC via the Raf/MEK/ERK signaling pathway

Wang

Lin

et al. 2018

Oncol Lett

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Abstract. Thyroid cancer is one of the most common types of cancer in the endocrine system. Among all types of thyroid cancer, papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Long non-coding RNA (lncRNA) BRAF-activated non-protein-coding RNA (BANCR) is a 688-bp-long nucleotide transcript, which was first identified in melanoma. The function of BANCR in thyroid cancer remains unclear. The aim of the present study was to investigate whether BANCR is involved in the development of thyroid cancer. The results indicated that BANCR expression was increased in thyroid tumors compared with in adjacent normal tissues. Among cancer cell lines, the expression level of BANCR differed: BANCR expression in BCPAP cell lines was lower compared with that in CAL-62, WRO and FTC-133 cell lines. Overexpression of BANCR promoted the migration and invasion of BCPAP cells. Additionally, BANCR mediated epithelial-mesenchymal transition (EMT) by regulating the expression of epithelial (E)-cadherin, vimentin and neuronal (N)-cadherin. Overexpression of BANCR in BCPAP cells decreased the expression of E-cadherin and increased the expression of vimentin, N-cadherin, phospho (p)-c-Raf, p-extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MEK)1/2 and p-ERK1/2. Administration of U0126 inhibitor inhibited the regulation of phosphorylation levels by MEK1/2 and ERK1/2. Additionally, U0126 upregulated the expression of E-cadherin and downregulated the expression of vimentin. Taken together, the results of the present study suggest that BANCR induces EMT in PTC through the Raf/MEK/ERK signaling pathway.

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“…This link between BANCR and the MAPK pathways points to a novel mechanism in the regulation of melanoma proliferation. 75 In a previous section, it was mentioned that BRAF V600E was associated with increased EZH2 expression and H3K27 trimethylation of tumor suppressor genes. It will be interesting to see if there is any correlation between the expression of BANCR and EZH2 or poor prognosis.…”

Section: Braf-activated Non-coding Rna (Bancr)mentioning

confidence: 98%