Long non-coding RNA BBOX1-AS1 exacerbates esophageal squamous cell carcinoma development by regulating HOXB7/β-catenin axis

A review on the role of gamma-butyrobetaine hydroxylase 1 antisense RNA 1 in the carcinogenesis and tumor progression

“…In respiratory system tumors, BBOX1-AS1 exhibits a significant positive correlation with larger tumor size, lymph node metastasis, and advanced Tumour-Node-Metastasis (TNM) stage in NSCLC [ 39 , 40 ]. Similarly, in digestive system tumors [ 41 , 43 , 44 , 46 – 48 ], BBOX1-AS1 shows a significant positive association with larger tumor size, lymph node metastasis, or advanced TNM stage. Notably, high BBOX1-AS1 expression is positively correlated with lymph node metastasis in esophageal carcinoma [ 41 , 44 ] and gastric cancer [ 48 ].…”

“…Several studies have reported a significant relationship between aberrant BBOX1-AS1 expression and cancer patient prognosis. As indicated in Table 1 , high expression of BBOX1-AS1 was found to predict poor overall survival in four types of cancers: non-small cell lung cancer [ 39 , 40 ], esophageal squamous cell carcinoma [ 41 , 43 , 44 ], hepatocellular carcinoma [ 46 , 47 ], and cervical cancer [ 53 ], as well as inferior disease-free survival in hepatocellular carcinoma [ 47 ]. Additionally, several prognostic models that incorporate BBOX1-AS1 have been developed.…”

“…In addition, BBOX1-AS1 has demonstrated diagnostic significance in lung cancer [ 38 ] and esophageal carcinoma [ 43 ]. Receiver Operating Characteristic (ROC) analysis revealed that BBOX1-AS1 could effectively distinguish tumor tissues from normal tissues, achieving an AUC value of 0.983 in lung squamous cell carcinoma [ 38 ] and 0.7668 in esophageal squamous cell carcinoma [ 43 ]. However, the diagnostic potential of BBOX1-AS1 in other types of cancers remains unexplored.…”

“…Furthermore, BBOX1-AS1’s influence extends beyond the ceRNA network, as it can also impact downstream targets. For example, HOXB7 is an essential downstream target of BBOX1-AS1, and HOXB7 is involved in the activation of the Wnt/β-catenin signaling pathway, contributing to malignant phenotypes in esophageal squamous cell carcinoma [ 43 ].…”

“…Currently, BBOX1-AS1 has been confirmed to participate in the regulation of the Hedgehog signaling pathway [ 42 ]. And the genes regulated by BBOX1-AS1 are also associated with other cancer-related signaling pathways, including the Wnt/β-catenin signaling pathway [ 43 ] and MELK/FAK signaling [ 39 ]. BBOX1-AS1’s involvement with these signaling pathways implies its broader impact on cancer cell behavior and therapeutic responses (Fig.…”