Long non-coding RNA CASC2 enhances cisplatin sensitivity in oral squamous cell cancer cells by the miR-31-5p/KANK1 axis

Wang, J; Jia, Jizeng; Zhou, Li-Na

doi:10.4149/neo_2020_191029n1102

Cited by 16 publications

(10 citation statements)

References 39 publications

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“…lncRNA ANRIL knockdown in tumor cells inhibits proliferation, induces apoptosis and increases cisplatin cytotoxicity in tumor cells via impairment of the drug transporters MRP1 and ABCC2, which can be restored by treatment with human MK in a caspase-3/BCL-2-dependent manner. Other apoptosis-related lncRNAs are summarized in Table 2 : XIST [ 129 ], HOXA11-AS [ 130 ], KCNQ1OT1 [ 131 , 132 ], CASC2 [ 133 , 134 ], HOTAIR [ 135 ]. Thus, targeting lncRNAs, not only in cancer cells, but also in cells in the surrounding cancer microenvironment, may be a new therapeutic approach for OSCC.…”

Section: Apoptosismentioning

confidence: 99%

Impact of Non-Coding RNAs on Chemotherapeutic Resistance in Oral Cancer

et al. 2022

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Drug resistance in oral cancer is one of the major problems in oral cancer therapy because therapeutic failure directly results in tumor recurrence and eventually in metastasis. Accumulating evidence has demonstrated the involvement of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in processes related to the development of drug resistance. A number of studies have shown that ncRNAs modulate gene expression at the transcriptional or translational level and regulate biological processes, such as epithelial-to-mesenchymal transition, apoptosis, DNA repair and drug efflux, which are tightly associated with drug resistance acquisition in many types of cancer. Interestingly, these ncRNAs are commonly detected in extracellular vesicles (EVs) and are known to be delivered into surrounding cells. This intercellular communication via EVs is currently considered to be important for acquired drug resistance. Here, we review the recent advances in the study of drug resistance in oral cancer by mainly focusing on the function of ncRNAs, since an increasing number of studies have suggested that ncRNAs could be therapeutic targets as well as biomarkers for cancer diagnosis.

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Section: Apoptosismentioning

confidence: 99%

Impact of Non-Coding RNAs on Chemotherapeutic Resistance in Oral Cancer

et al. 2022

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“… Peng et al [ 42 ] OSCC tissues and cells Up; Oncogenic Proliferation, migration, invasion, and EMT LATS2 Hippo signaling pathway ↓ miR-31 level was markedly increased in OSCC tissues; circ_0000140 negatively associated with miR-31 expression ( r 2 = 0.43, P < 0.001) and positively associated with LATS2 expression ( r 2 = 0.60, P < 0.001). Wang et al [ 43 ] OSCC tissues and cells Up; Oncogenic Apoptosis, cisplatin sensitivity KANK1 Long non-coding RNA CASC2- miR-31-5p/KANK1 axis ↑ miR-31-5p was upregulated in cisplatin-resistant OSCC tissues and cells, KANK1 acted as a target for miR-31-5p; CASC2 modulated KANK1 expression via sponging miR-31-5p. Kumari et al [ 44 ] Patients saliva Up; Oncogenic Clinical study Clinical study Clinical study The salivary miR-31 level was significantly higher in the preoperative patients than that of postoperative ( P < 0.001).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, miR-31 was also identified to be associated with the chemotherapy resistance of OSCC treatments. For example, Wang et al [ 43 ] found that miR-31-5p was upregulated in cisplatin-resistant OSCC tissues. The above evidence demonstrated that high expression of miR-31 was closely associated with the clinicopathologic features of OSCC, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Cisplatin is one of the common-used first-line chemotherapy regimens for treating OSCC but usually fails because of chemoresistance [ 53 ]. miR-31-5p upregulation was found in cisplatin-resistant OSCC, which was considered to be associated with the anti-apoptosis characteristic of miR-31 [ 43 ]. Tumor-associated macrophages are the crucial elements of the tumor microenvironment.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA-31: a pivotal oncogenic factor in oral squamous cell carcinoma

Lin

Wu²,

Ying

et al. 2022

Cell Death Discov.

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Oral squamous cell carcinoma (OSCC) continuously constitutes a major challenge for treatment and prognosis due to approximately half of treated OSCC patients dying from locoregional recurrences and distant metastases. MicroRNA-31 (miR-31), an early mammalian miRNA identified, has been gaining importance in the field of OSCC research in recent years. This comprehensive review was conducted for the first time to summarize the current evidence on the association between miR-31 and OSCC. The vast majority of relevant studies (20/21, 95%) demonstrated that miR-31 was an oncogenic factor in the tumorigenesis and progression of OSCC. miR-31 expression is significantly upregulated in plasma, saliva, and tumor tissue of OSCC. miR-31 played an essential role in OSCC development by constituting a complex network with its targeted genes (e.g. RhoA, FIH, ACOX1, VEGF, SIRT3, LATS2, KANK1, and NUMB) and the signaling cascades (e.g. EGF-AKT signaling axis, ERK-MMP9 cascade, Hippo pathway, Wnt signaling, and MCT1/MCT4 regulatory cascade). This review highlights that miR-31 might function as a potential diagnostic, prognostic, and predictive biomarker for OSCC. Further studies are still warranted to better illuminate the clinicopathological features and the molecular mechanisms of miR-31-mediated OSCC development.

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“…13 And the relationship between CASC2 and miR-31-5p has been reported. 14 However, the expression pattern and function of CASC2 in asthma remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Differential Expression of lncRNA CASC2 in the Serum of Childhood Asthma and Its Role in Airway Smooth Muscle Cells Proliferation and Migration

Yang¹,

Sun²,

Ren³

et al. 2022

JAA

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Asthma is a common chronic disease in children. Abnormal expression of lncRNAs can be used as biomarkers for early diagnosis of asthma. The present study aimed to explore the expression change and clinical value of lncRNA CASC2 in asthma, and further investigate its potential mechanism. Patients and Methods: Seventy asthma children and 66 healthy controls were recruited. Levels of mRNAs were detected using qRT-PCR. Receiver operating characteristic (ROC) curves were drawn for diagnostic value evaluation. Asthma cell models were established using PDGF-BB in Human airway smooth muscle cells (ASMCs). Levels of Th1/Th2 related cytokines were detected using ELISA. Lipofectamine 3000 was used for cell transfection. The target relationship was verified using luciferase activity assay. Results: CASC2 was at a low level in asthma children in comparison with the healthy controls. Serum CASC2 can distinguish healthy individuals from asthma children. Overexpression of CASC2 inhibited PDGF-BB induced cell proliferation and migration. CASC2 upregulation inhibited the release of Th2 related cytokines (IL-4 and IL-10), but promoted the release of Th1-related cytokine (IFN-γ). In PDGF-BB treated ASMCs, the reduced expression of contractile phenotype marker (α-SMA) was detected, but the trend was reversed by CASC2 upregulation. LncRNA CASC2 serves as a ceRNA of miR-31-5p, overexpression of miR-31-5p reversed the influence of CASC2 on asthma in vitro. Conclusion: Serum CASC2 can distinguish healthy individuals from asthma children. CASC2 may be involved in childhood asthma through inhibiting ASMCs proliferation, migration and inflammation via sponging miR-31-5p.

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Long non-coding RNA CASC2 enhances cisplatin sensitivity in oral squamous cell cancer cells by the miR-31-5p/KANK1 axis

Cited by 16 publications

References 39 publications

Impact of Non-Coding RNAs on Chemotherapeutic Resistance in Oral Cancer

Impact of Non-Coding RNAs on Chemotherapeutic Resistance in Oral Cancer

MicroRNA-31: a pivotal oncogenic factor in oral squamous cell carcinoma

Differential Expression of lncRNA CASC2 in the Serum of Childhood Asthma and Its Role in Airway Smooth Muscle Cells Proliferation and Migration

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