2013
DOI: 10.1007/s11427-013-4558-1
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Long non-coding RNA-guided regulation in organisms

Abstract: It is clear that RNA is more than just a messenger between gene and protein. The mammalian genome is pervasively transcribed, giving rise to tens of thousands of non-coding transcripts. Whether all of these transcripts are functional remains to be elucidated, but it is evident that there are many functional long non-coding RNAs (lncRNAs). Recent studies have set out to decode the regulatory role and functional diversity of lncRNAs. Here we organize these studies to highlight the significant involvements of lnc… Show more

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Cited by 11 publications
(6 citation statements)
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“…Long noncoding RNAs (lncRNAs) are a group of endogenous cellular RNAs of more than 200 bp long that encoded by mammalian genome, which couldnot encode proteins for the lack of an open reading frame (Li, Tian, Yang, & Gong, ). LncRNAs may function as signals, guides, decoys, and scaffolds in diverse vital physiological and pathological processes (Bonasio & Shiekhattar, ; Mathieu, Belhocine, Dao, Puthier, & Spicuglia, ; Qi, Song, & Li, ; Ulitsky & Bartel, ). In particular, studies on cancer have proved that lncRNAs actively participated in the regulaton of cancer development and progression, such as cancer growth, metastasis, and recurrence (e.g., H19 (Liang et al, ), HOTAIR (Zhang et al, ), MALAT‐1 (Li, Zou, Xie, et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…Long noncoding RNAs (lncRNAs) are a group of endogenous cellular RNAs of more than 200 bp long that encoded by mammalian genome, which couldnot encode proteins for the lack of an open reading frame (Li, Tian, Yang, & Gong, ). LncRNAs may function as signals, guides, decoys, and scaffolds in diverse vital physiological and pathological processes (Bonasio & Shiekhattar, ; Mathieu, Belhocine, Dao, Puthier, & Spicuglia, ; Qi, Song, & Li, ; Ulitsky & Bartel, ). In particular, studies on cancer have proved that lncRNAs actively participated in the regulaton of cancer development and progression, such as cancer growth, metastasis, and recurrence (e.g., H19 (Liang et al, ), HOTAIR (Zhang et al, ), MALAT‐1 (Li, Zou, Xie, et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…While more than 70% of the human genome is reportedly transcribed into different types of RNA, less than 2% encodes protein . LncRNAs have been validated in many human tissues and cells and may function in diverse, vital physiological and pathological processes, especially during tumor development …”
Section: Introductionmentioning
confidence: 99%
“…Many functional lncRNAs show tissue-specific expression patterns and distinct subcellular localizations [ 9 , 11 , 13 , 14 ]. Growing evidence suggests that lncRNAs are important modulators of gene expression via their interaction with DNA, RNA, or protein [ 15 25 ], while determining the function of individual lncRNAs remains a challenge. Some lncRNAs have been shown to regulate osteogenic differentiation of MSCs [ 26 31 ].…”
Section: Introductionmentioning
confidence: 99%