Long Non-Coding RNA HOTAIR in Breast Cancer Therapy

Cantile, Monica; Bonito, Maurizio Di; Cerrone, Margherita; Collina, Francesca; Laurentiis, Michelino De; Botti, Gerardo

doi:10.3390/cancers12051197

Cited by 85 publications

(55 citation statements)

References 163 publications

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“…Although numerous studies have highlighted the crucial role of HOTAIR in several physiological cellular processes, indicating it as a cell cycle-related gene [ 38 ], most experimental observations are oriented to understanding its role in tumorigenesis [ 29 ]. In fact, the overexpression of HOTAIR has been related to the evolution of some solid cancers [ 26 , 39 , 40 ] with a crucial role in cancer initiation, progression, and drug sensibility modulation [ 41 , 42 ].…”

Section: Hotair and Its Role In Cancermentioning

confidence: 99%

Functional Interaction among lncRNA HOTAIR and MicroRNAs in Cancer and Other Human Diseases

Cantile

Bonito

Tracey

et al. 2021

Cancers

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LncRNAs are a class of non-coding RNAs mostly involved in regulation of cancer initiation, metastatic progression, and drug resistance, through participation in post-transcription regulatory processes by interacting with different miRNAs. LncRNAs are able to compete with endogenous RNAs by binding and sequestering miRNAs and thereby regulating the expression of their target genes, often represented by oncogenes. The lncRNA HOX transcript antisense RNA (HOTAIR) represents a diagnostic, prognostic, and predictive biomarker in many human cancers, and its functional interaction with miRNAs has been described as crucial in the modulation of different cellular processes during cancer development. The aim of this review is to highlight the relation between lncRNA HOTAIR and different microRNAs in human diseases, discussing the contribution of these functional interactions, especially in cancer development and progression.

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Section: Hotair and Its Role In Cancermentioning

confidence: 99%

Functional Interaction among lncRNA HOTAIR and MicroRNAs in Cancer and Other Human Diseases

Cantile

Bonito

Tracey

et al. 2021

Cancers

Self Cite

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“…The activity of pro-survival factors, including Akt, ERK, and BCL-2, is also diminished by the downregulation of lncRNA-HOTAIR [ 257 , 258 ]. The oncogenic function of lncRNA-HOTAIR can be exerted by direct or indirect suppression of several tumor-suppressive miRNAs, such as miR-7, miR-34, miR-126, and miR-206 [ 259 , 260 ]. Consistent with these findings, it was demonstrated that lncRNA-HOTAIR promotes the anoikis resistance, anchorage-independent growth, and peritoneal/liver metastasis of gastric cancer cells [ 245 , 246 ] ( Figure 3 and Table 3 ).…”

Section: Long Noncoding Rnas Anoikis and Anchorage-independent Gmentioning

confidence: 99%

The Role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer

Lee

Son

Moeng

et al. 2021

IJMS

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Cancer is a global health concern, and the prognosis of patients with cancer is associated with metastasis. Multistep processes are involved in cancer metastasis. Accumulating evidence has shown that cancer cells acquire the capacity of anoikis resistance and anchorage-independent cell growth, which are critical prerequisite features of metastatic cancer cells. Multiple cellular factors and events, such as apoptosis, survival factors, cell cycle, EMT, stemness, autophagy, and integrins influence the anoikis resistance and anchorage-independent cell growth in cancer. Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are dysregulated in cancer. They regulate cellular signaling pathways and events, eventually contributing to cancer aggressiveness. This review presents the role of miRNAs and lncRNAs in modulating anoikis resistance and anchorage-independent cell growth. We also discuss the feasibility of ncRNA-based therapy and the natural features of ncRNAs that need to be contemplated for more beneficial therapeutic strategies against cancer.

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“…Tumor cells present a number of characteristics, such as self-proliferation ability [ 2 ], apoptosis resistance [ 3 ], unlimited replication potential [ 4 ], insensitivity to growth inhibition [ 5 ], continuous angiogenesis [ 6 ], tissue invasion [ 7 ] and metastasis [ 8 ]. Mammary tumorigenesis is a multistep process involving activation of oncogenes or inactivation of tumor suppressors, abnormal expression of noncoding RNA [ 9 ], loss of genome stability [ 10 ] and various genetic and epigenetic alterations [ 11 ]. Tumor cells prefer glycolysis for glucose metabolism under aerobic conditions (Warburg effect) rather than mitochondrial oxidative phosphorylation, which is more efficient for ATP production so that tumor cells can produce more energy and various metabolites in a short period of time [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The miR-1185-2-3p—GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1

Chen

Liang

et al. 2021

J Exp Clin Cancer Res

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Background Phosphatidylinositol-4-phosphate-binding protein GOLPH3L is overexpressed in human ductal carcinoma of the breast, and its expression levels correlate with the prognosis of breast cancer patients. However, the roles of GOLPH3L in breast tumorigenesis remain unclear. Methods We assessed the expression and biological function of GOLPH3L in breast cancer by combining bioinformatic prediction, metabolomics analysis and RNA-seq to determine the GOLPH3L-related pathways involved in tumorigenesis. Dual-luciferase reporter assay and coimmunoprecipitation (Co-IP) were used to explore the expression regulation mechanism of GOLPH3L. Results We demonstrated that knockdown of GOLPH3L in human breast cancer cells significantly suppressed their proliferation, survival, and migration and suppressed tumor growth in vivo, while overexpression of GOLPH3L promoted aggressive tumorigenic activities. We found that miRNA-1185-2-3p, the expression of which is decreased in human breast cancers and is inversely correlated with the prognosis of breast cancer patients, is directly involved in suppressing the expression of GOLPH3L. Metabolomics microarray analysis and transcriptome sequencing analysis revealed that GOLPH3L promotes central carbon metabolism in breast cancer by stabilizing the p53 suppressor SERPINE1. Conclusions In summary, we discovered a miRNA-GOLPH3L-SERPINE1 pathway that plays important roles in the metabolism of breast cancer and provides new therapeutic targets for human breast cancer.

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Long Non-Coding RNA HOTAIR in Breast Cancer Therapy

Cited by 85 publications

References 163 publications

Functional Interaction among lncRNA HOTAIR and MicroRNAs in Cancer and Other Human Diseases

Functional Interaction among lncRNA HOTAIR and MicroRNAs in Cancer and Other Human Diseases

The Role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer

The miR-1185-2-3p—GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1

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