Long non-coding RNA HOTAIR in carcinogenesis and metastasis

Zhang, Jinsong; Zhang, Peijing; Wang, Li; Piao, Hai Long; Ma, Li

doi:10.1093/abbs/gmt117

Cited by 163 publications

(137 citation statements)

References 32 publications

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“…Several recent studies have identified the aberrant expression of HOTAIR in a number of cancer types, including breast, colon, bladder, renal, pancreatic, cervical and lung cancer, and a high level of HOTAIR expression has been correlated with enhanced breast, colon and gastric cancer metastasis. In addition, HOTAIR-knockdown is able to inhibit the invasion and proliferation of cells, as well as altering cell cycle progression and inducing cells apoptosis, thus indicating that HOTAIR may function in the modulation of cancer progression (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia

Zheng

Chen

et al. 2015

Oncology Letters

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Abstract. The long non-coding RNA, HOX transcript antisense intergenic RNA (HOTAIR), has been indicated to have involvement in a number of cancers, however, its role in acute myeloid leukemia (AML) is unknown. The present study aimed to investigate the pattern of HOTAIR expression in AML and to evaluate its clinical significance in tumor progression. Quantitative polymerase chain reaction was performed to examine the HOTAIR expression in mononuclear cells from the bone marrow (BM) or peripheral blood specimens of 85 patients with newly diagnosed AML. The association of HOTAIR expression with the clinicopathological factors and prognosis of AML patients was statistically analyzed. The expression of HOTAIR was significantly upregulated in the AML patients compared with the healthy controls (mean expression value, 3.87±0.29 vs. 1.28±0.09; P<0.001), and markedly decreased in the patients post-treatment compared with pre-treatment (4.76±0.47 vs. 2.81±0.27; P<0.001). Moreover, high levels of HOTAIR were associated with higher white blood cell and BM blast counts (P<0.001 and P=0.001, respectively), and lower hemoglobin and platelet counts (P=0.007 and 0.001, respectively). Patients with a high level of HOTAIR expression had relatively poor overall survival (OS; 20.5 vs. 32.1 months, P=0.001) and relapse-free survival (21.5 vs. 33.6 months, P=0.001) times compared with those with a low level of HOTAIR expression. These data demonstrated that HOTAIR expression was upregulated in newly diagnosed AML patients and was associated with leukemic burden, and DFS and OS times. HOTAIR may represent a biomarker of a poor prognosis and is a potential therapeutic target for AML treatment.

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Section: Introductionmentioning

confidence: 99%

Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia

Zheng

Chen

et al. 2015

Oncology Letters

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“…Furthermore, studies suggest that their expression patterns are even more tissue-specific than those of protein-coding genes (Cabili et al 2011) and that they are involved in pivotal tumor suppressive and oncogenic pathways. Increased expression of the lncRNA HOTAIR in primary breast tumors, for instance, was shown to strongly correlate with metastasis and death (Gupta et al 2010), with similar up-regulation and prognostic significance observed in a number of other cancers, including nonsmall cell lung cancer and pancreatic cancer (Zhang et al 2014). Similarly, overexpression of the lncRNA MALAT-1 has been linked to hepatocellular carcinoma and metastasis in small-cell lung cancer (Lin et al 2007).…”

Section: Introductionmentioning

confidence: 80%

Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma

Zou

Honda

et al. 2015

RNA

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Head and neck squamous cell carcinoma persists as one of the most common and deadly malignancies, with early detection and effective treatment still posing formidable challenges. To expand our currently sparse knowledge of the noncoding alterations involved in the disease and identify potential biomarkers and therapeutic targets, we globally profiled the dysregulation of small nucleolar and long noncoding RNAs in head and neck tumors. Using next-generation RNA-sequencing data from 40 pairs of tumor and matched normal tissues, we found 2808 long noncoding RNA (lncRNA) transcripts significantly differentially expressed by a fold change magnitude ≥2. Meanwhile, RNA-sequencing analysis of 31 tumor-normal pairs yielded 33 significantly dysregulated small nucleolar RNAs (snoRNA). In particular, we identified two dramatically downregulated lncRNAs and one down-regulated snoRNA whose expression levels correlated significantly with overall patient survival, suggesting their functional significance and clinical relevance in head and neck cancer pathogenesis. We confirmed the dysregulation of these noncoding RNAs in head and neck cancer cell lines derived from different anatomic sites, and determined that ectopic expression of the two lncRNAs inhibited key EMT and stem cell genes and reduced cellular proliferation and migration. As a whole, noncoding RNAs are pervasively dysregulated in head and squamous cell carcinoma. The precise molecular roles of the three transcripts identified warrants further characterization, but our data suggest that they are likely to play substantial roles in head and neck cancer pathogenesis and are significantly associated with patient survival.

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“…According to their alternative expression pattern, certain lncRNAs may reflect the progress of disease, and may be regarded as independent predictors for cancer diagnosis (14,16,31,32). The overexpression of Hox transcript antisense RNA in breast cancer promoted metastasis (33,34) and homeobox A transcript at the distal tip is considered an indicator for determining the progress of pancreatic cancer (35). Prostate cancer associated transcript 1 identified in hepatocellular carcinoma has been associated with the prognosis in patients with hepatocellular carcinoma (36).…”

Section: Discussionmentioning

confidence: 99%

lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma

et al. 2017

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Abstract. The mechanism of nasopharyngeal carcinoma (NPC) remains unclear. The present study investigated the abnormal expression of long non-coding (lnc)RNAs in NPC tissues and one NPC cell line to identify the involvement of lncRNAs in the tumorigenesis of NPC. Using a quantitative reverse transcription polymerase chain reaction (RT-qPCR), the expression of lncRNA C22orf32-1 in NPC tissues and an NPC cell line was verified. The effects of lncRNA C22orf32-1 on NPC cells were investigated with a cell proliferation assay, cell scratch assay, Transwell assay and a cell apoptosis assay. The expression levels of lncRNA C22orf32-1 in NPC tissues and an NPC cell line were upregulated. lncRNA C22orf32-1 promoted the proliferation, migration and invasion of NPC cells, and reduced the apoptosis of NPC cells. The data demonstrated that lncRNA C22orf32-1 may facilitate the tumorigenesis of NPC, and may be used for the early diagnosis and treatment of NPC.

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Long non-coding RNA HOTAIR in carcinogenesis and metastasis

Cited by 163 publications

References 32 publications

Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia

Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia

Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma

lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma

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