Long non-coding RNA HOTAIR modulates the progression of preeclampsia through inhibiting miR-106 in an EZH2-dependent manner

Zhao, Yanhua; Liu, Yue-Lan; Fei, Kuilin; Li, Ping

doi:10.1016/j.lfs.2020.117668

Cited by 33 publications

(16 citation statements)

References 41 publications

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“…The results from many in vitro studies clearly indicate that miRNAs belonging to C19MC are important factors in controlling crucial processes required for adequate placentation, and that dysregulation of C19MC could lead to the impaired function of the trophoblast cells, impaired placentation and consequently PE development [ 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ]. In addition, upregulation and downregulation of specific lncRNAs can also impact trophoblast proliferation, invasion, migration as well as apoptosis [ 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 ].…”

Section: Discussionmentioning

confidence: 99%

“…So far, particular roles of several lncRNAs in PE development and progression have been described. Upregulation and downregulation of specific lncRNAs can impact critical mechanisms in the development of PE and lead to changes in trophoblast proliferation, invasion, migration and apoptosis Table 2 [ 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 ].…”

Section: Long Non-coding Rnasmentioning

confidence: 99%

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Non-Coding RNAs in Preeclampsia—Molecular Mechanisms and Diagnostic Potential

Munjas

Sopić

Stefanović

et al. 2021

IJMS

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Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Defects in trophoblast invasion, differentiation of extravillous trophoblasts and spiral artery remodeling are key factors in PE development. Currently there are no predictive biomarkers clinically available for PE. Recent technological advancements empowered transcriptome exploration and led to the discovery of numerous non-coding RNA species of which microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the most investigated. They are implicated in the regulation of numerous cellular functions, and as such are being extensively explored as potential biomarkers for various diseases. Altered expression of numerous lncRNAs and miRNAs in placenta has been related to pathophysiological processes that occur in preeclampsia. In the following text we offer summary of the latest knowledge of the molecular mechanism by which lnRNAs and miRNAs (focusing on the chromosome 19 miRNA cluster (C19MC)) contribute to pathophysiology of PE development and their potential utility as biomarkers of PE, with special focus on sample selection and techniques for the quantification of lncRNAs and miRNAs in maternal circulation.

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Section: Discussionmentioning

confidence: 99%

Section: Long Non-coding Rnasmentioning

confidence: 99%

Non-Coding RNAs in Preeclampsia—Molecular Mechanisms and Diagnostic Potential

Munjas

Sopić

Stefanović

et al. 2021

IJMS

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“… [ 138 ] LOC284100 placenta upregulated / / CEACAMP8 placenta upregulated / / HOTAIR placenta upregulated miR-106a High level of HOTAIR represses the proliferation, migration and invasion of trophoblast cells through downregulating miR-106 in an EZH2-dependent manner. [ 139 ] downregulated PUM1/HOTAIR HOTAIR promotes trophoblast invasion by activating PI3K-AKT signaling pathway. [ 140 ] AGAP2-AS1 placenta downregulated JDP2 AGAP2-AS1 knockdown could inhibit trophoblasts proliferation, invasion and spiral artery remodeling and promote cell apoptosis.…”

Section: Lncrnas and Pementioning

confidence: 99%

“…Although there is no report that the methylation level of lncRNA itself is related to PE, abnormally expressed lncRNAs can regulate the proliferation, invasion, and apoptosis of trophoblasts by regulating the methylation of downstream molecules. Zhao et al found that when lncRNA HOTAIR is expressed at high levels, it targets miR-106 by binding to EZH2 [ 139 ], which in turn inhibits the transcription of the target gene by inducing H3K27 methylation in the promoter region, ultimately suppressing the proliferation, migration, and invasion of trophoblasts [ 190 ]. Xu et al further confirmed that EZH2 can directly interact with the promoter region of RND3 by methylating H3K27, the 27th amino acid of histone H3, thereby reducing the expression of RND3 in PE.…”

Section: Lncrnas and Pementioning

confidence: 99%

Roles of noncoding RNAs in preeclampsia

Sun

Qin

Zhang

et al. 2021

Reprod Biol Endocrinol

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Preeclampsia (PE) is an idiopathic disease that occurs during pregnancy. It comprises multiple organ and system damage, and can seriously threaten the safety of the mother and infant throughout the perinatal period. As the pathogenesis of PE is unclear, there are few specific remedies. Currently, the only way to eliminate the clinical symptoms is to terminate the pregnancy. Although noncoding RNA (ncRNA) was once thought to be the “junk” of gene transcription, it is now known to be widely involved in pathological and physiological processes, including pregnancy-related disorders. Moreover, there is growing evidence that the unbalanced expression of specific ncRNA is involved in the pathogenesis of PE. In the present review, we summarize the expression patterns of ncRNAs, i.e., microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), and the functional mechanisms by which they affect the development of PE, and examine the clinical significance of ncRNAs as biomarkers for the diagnosis of PE. We also discuss the contributions made by genetic polymorphisms and epigenetic ncRNA regulation to PE. In the present review, we wish to explore and reinforce the clinical value of ncRNAs as noninvasive biomarkers of PE.

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“…In addition downregulation of miRNA-29b in the placenta was observed during gestational diabetes, which might change placental development by regulating trophoblast migration and invasion (Sun et al, 2020). Zhao et al (Zhao et al, 2020) found that high levels of lncRNA HOTAIR inhibited the proliferation, migration, and invasion of trophoblasts by targeting miR-106 in an enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2)-dependent manner. In addition (Shen et al, 2019), showed that CircTRNC18 inhibits trophoblast cell migration and epithelial-mesenchymal transformation by regulating the miR-762/grainyhead like transcription factor 2 (GRHL2) pathway of preeclampsia.…”

Section: Epithelial To Mesenchyme Transition(emt) Invasion and Metastasismentioning

confidence: 99%

Non-Coding RNAs Regulate Placental Trophoblast Function and Participate in Recurrent Abortion

et al. 2021

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Recurrent spontaneous abortion (RSA) is a serious pregnancy complication with an increasing clinical incidence. The various causes of recurrent abortion are complicated. Developments in genetics, immunology, and cell biology have identified important roles of non-coding RNAs (ncRNAs) in the occurrence and progress of recurrent abortion. NcRNAs can affect the growth, migration, and invasion of placental trophoblasts by regulating cell processes such as the cell cycle, apoptosis, and epithelial-mesenchymal transformation. Therefore, their abnormal expression might lead to the occurrence and development of RSA. NcRNAs include small nuclear RNA (snRNA), small nucleolar RNA (snoRNA), ribosomal RNA (rRNA), transfer, RNA (tRNA), circular RNA (cRNA), and Piwi-interacting RNA (piRNA). In this review, we discuss recent research that focused on the function and mechanism of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNA (circRNA) in regulating placental trophoblasts. The use of ncRNAs as potential diagnostic and predictive biomarkers in RSA is also discussed to provide future research insights.

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Long non-coding RNA HOTAIR modulates the progression of preeclampsia through inhibiting miR-106 in an EZH2-dependent manner

Cited by 33 publications

References 41 publications

Non-Coding RNAs in Preeclampsia—Molecular Mechanisms and Diagnostic Potential

Non-Coding RNAs in Preeclampsia—Molecular Mechanisms and Diagnostic Potential

Roles of noncoding RNAs in preeclampsia

Non-Coding RNAs Regulate Placental Trophoblast Function and Participate in Recurrent Abortion

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