Long non‑coding RNA HOTTIP is able to predict poor prognosis in various neoplasms: A meta‑analysis

Abstract

Abstract. HOXA distal transcript antisense RNA (HOTTIP), a critical oncogenic long non-coding RNA, has been reported to be aberrantly regulated in various cancer types. The present meta-analysis aimed to investigate HOTTIP as a potential clinical applicable prognostic biomarker in malignant neoplasms. Literature collections were performed by searching the electronic databases, PubMed and Web of Science (up to July 20, 2016). All the relevant searches were conducted to identify the association of HOTTIP with the overall survival (OS) rate. A total of six articles consisting of 508 patients were included in the present meta-analysis. The results suggested that the overexpression of HOTTIP is closely correlated with poor OS (hazard ratio=2.28; 95% confidence interval=1.71-3.04; P=0.000). In conclusion, the present meta-analysis has demonstrated that an increased expression level of HOTTIP is correlated with poor OS in different types of cancer, suggesting that HOTTIP potentially serves as a reliable prognostic biomarker in different types of cancer.

Long non-coding RNA HOTAIR and HOTTIP as potential biomarkers for hepatitis C virus genotype 4-induced hepatocellular carcinoma

“…The contribution of HOTTIP as having oncogenic roles has been revealed in tumorigenesis; recent advances have confirmed that HOTTIP is frequently overexpressed in many tumors to play oncogenic roles in cancer development and progression, including HCC [31]. HOTTIP expression was noticed to increase the HCC cell proliferation [48] and was associated with HCC progression and poor clinical outcome [31,49]. The diagnostic performance of HOTAIR and HOTTIP gene expressions as markers in cirrhotic patients at different cut-off points using ROC curve showed that no significant difference between cirrhotic and noncirrhotic patients regarding HOTAIR at the cut-off value of 4.7, with sensitivity of 48.0% and specificity of 72.0% with areas under curve (AUC) of 52.0 (p value = 0.8, 95% confidence interval C.I 35.6%-68.4%) and accuracy of 60.0%, also no significant difference between cirrhotic and non-cirrhotic patients regarding HOTTIP at the cut-off value of 13.4, with sensitivity of 32.0% and specificity of 100.0% with areas under curve (AUC) of 53.9 (p value = 0.640, 95% confidence interval C.I 37.1%-70.8%) and accuracy of 66.0%.…”

Prognostic and clinicopathological significance of long noncoding RNA HOXA11-AS expression in human solid tumors: a meta-analysis

“…Many lncRNAs are identified in various types of cancers, and their dysregulated expression is correlated with tumor progression and patients’ survival, thus making them promising markers for the diagnosis and prognosis. For example, the lncRNAs TUG1 [ 36 ], UCA1 [ 37 ], SPRY4-IT1 [ 38 ], HULC [ 9 ], HOTTIP [ 39 ], H19 [ 40 ] and HOTAIR [ 41 ] were found to be novel promising biomarkers for poor prognosis in human cancers.…”

The Role of Long Non-Coding RNAs in Hepatocarcinogenesis

“…Its role in human carcinogenesis was firstly revealed in HCC [ 89 ] and has since been described in colorectal [ 123 , 124 ], gastric [ 125 , 126 , 127 ], pancreatic [ 128 , 129 ], and lung cancers [ 130 ], as well as in osteosarcoma [ 131 ] and glioma [ 132 ]. The results from these studies were collectively analyzed in three parallel meta-analyses, all of which clearly showed that the high expression of HOTTIP correlates with shorter overall survival, higher tumor grade and poor prognosis [ 133 , 134 , 135 ].…”