Long non‐coding RNA LINC00968 acts as oncogene in NSCLC by activating the Wnt signaling pathway

Abstract

Long non-coding RNAs (lncRNAs) have played critical roles in a variety of cancers, including non-small cell lung cancer (N SCLC). In our study, we focused on the biological function and clinical significance of lncRNA LINC00968 in NSCLC. It was indicated that LINC00968 was significantly increased in LUAD tissues, LUSC tissues and NSCLC cells compared to their corresponding controls. Inhibition of LINC00968 was able to repress NSCLC growth, migration, and invasion in vitro while upregulation of LINC00968 reversed this process. Additionally, downregulation of LINC00968 induced apoptosis capacity of A549 cell. Apoptosis-related proteins BCL-2 were decreased and BAX was increased by knockdown of LINC00968, respectively. Meanwhile we observed that Wnt signaling pathway was involved in the LINC00968-induced NSCLC progression. Finally, in vivo tumor xenografts were established using A549 cells to detect the function of LINC00968 in NSCLC tumorigenesis. Silencing LINC00968 greatly inhibited NSCLC tumor progression, which was consistent with the in vitro tests. In conclusion, we have uncovered that LINC00968 could be regarded as a novel prognostic biomarker and therapeutic target in NSCLC diagnosis and treatment.

Long noncoding RNA NEAT1‐modulated miR‐506 regulates gastric cancer development through targeting STAT3

“…It was predicted that STAT3 can be provided as an miR-506 target. [23][24][25] LncRNA ILF3-AS1 can promote melanoma development through targeting miR-200b/a/429. LncRNAs are transcripts with more than 200 nucleotides and show no protein-coding capacity.…”

“…21 They are manifested to be involved in biological processes. [23][24][25] LncRNA MLLT4 antisense RNA 1 is decreased and can act as a potential indicator of poor prognosis in GC. [23][24][25] LncRNA ILF3-AS1 can promote melanoma development through targeting miR-200b/a/429.…”

“…26 LncRNA SNHG17 is able to promote cell proliferation by acting as an unfavorable prognostic indicator and epigenetically inhibiting P57 in colorectal cancer. [23][24][25] can play various roles in digestive system cancers and might be a possible prognostic biomarker in digestive system carcinoma patients. [23][24][25] LncRNA MLLT4 antisense RNA 1 is decreased and can act as a potential indicator of poor prognosis in GC.…”

MicroRNAs associated with lung squamous cell carcinoma: New prognostic biomarkers and therapeutic targets

“…Proteoglycans have an indispensable role in the tumor microenvironment, and as a result, many studies have described their potential use as target genes, biomarkers, and active agents . Moreover, it has been found that mutations in cell cycle genes can affect the differentiation of squamous cells in the course of modern anticancer treatment research . Pathways in cancer, which describes important signaling pathways such as Wnt signaling and T‐cell receptor signaling, is also an important factor in the progression of NSCLC and development of squamous cell carcinoma of the lung …”

A Combined Bioinformatics and Literature Based Approach for Identification of Long Non-coding RNAs That Modulate Vitamin D Receptor Signaling in Breast Cancer

“…LINC00672 amplification (3-8%) ERBB2 endometrial cancer [36] LINC00968 amplification (4-13%) ERBB2 non-small cell lung cancer [37] LINC01132 amplification (4-24%) GATA3, cMYC, ZNF217 TP53, FGFR, ERBB2, cMYC mir-31…”