Long Non-coding RNA LINC01094 Promotes the Development of Clear Cell Renal Cell Carcinoma by Upregulating SLC2A3 via MicroRNA-184

Xu, Haowen; Wang, Xiaolin; Wu, Jiacheng; Ji, Hao; Chen, Zhigang; Guo, Haifeng; Hou, Jianquan

doi:10.3389/fgene.2020.562967

Cited by 26 publications

(24 citation statements)

References 29 publications

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“…Chen HY et al have reported that the expression level of LINC01094 was prominently increased in ovarian cancer tissues compared with adjacent normal tissues, and LINC01094 overexpression promoted the viability, migration and invasion of ovarian cancer cells (Chen et al, 2021a). Consistently, LINC01094 was highly expressed in the clear cell renal cell carcinoma compared with adjacent normal tissues, and the LINC01094 overexpression was associated with a poor prognosis for the patients with clear cell renal cell carcinoma (Xu et al, 2020). In present study, we rstly found that the overexpression of LINC01094 was associated with a poor prognosis for GC patients.…”

Section: Discussionsupporting

confidence: 81%

Construction of a Novel Prognostic Immune-Related LncRNA Risk Model for Gastric Cancer

Yang

2021

Preprint

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Background and AimStudies have recently shown that immune-related lncRNAs play a vital role in the occurrence and development of human malignancies. However, the study in gastric cancer (GC) remains unclear. Here, we aimed to identify immune-related lncRNAs and construct a risk score model to predict the prognosis of GC patients.Methods:RNA expression data and clinical characteristics of GC were download from The Cancer Genome Atlas (TCGA) database. Immune genes were obtained from the Molecular Signatures Database (MSigDB). Immune-related lncRNAs were acquired by correlation coefficient between the immune genes and lncRNAs using “limma R” package and Cytoscape 3.6.1. The risk score model was constructed by univariate and multivariate Cox regression, and its prognostic value was verified in TCGA cohort. Results:A total of 146 immune-related lncRNAs were obtained compared 375 GC samples with 32 normal samples. A five immune-related lncRNA (AP001528.2, LINC02542, LINC02526, PVT1 and LINC01094) risk score model was constructed to predict prognosis of GC patients by Cox regression analysis. Moreover, GC patients with higher risk score had a poorer overall survival than that with lower risk score (P<0.001). Furthermore, ROC analysis revealed that the risk score model had the best predictive effect compared with clinicopathological features during 5 years followed-up (AUC = 0.679). Indeed, PCA analysis showed that the patients in the low- and high- group were significantly distinguished in different directions based on the risk score model. Conclusion:This study indicated that a five immune-related lncRNA risk score model possessed a satisfactory predictive prognosis, which might be potential prognostic biomarkers and immunotherapy targets for GC patients in future.

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Section: Discussionsupporting

confidence: 81%

Construction of a Novel Prognostic Immune-Related LncRNA Risk Model for Gastric Cancer

Yang

2021

Preprint

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“…Silencing lncRNA plasmacytoma variant translocation 1 suppressed OC cell proliferation, migration and invasion (44). Moreover, inhibiting LINC01094 attenuated proliferation, migration and invasion of ccRCC cells (17). LINC01094 overexpression promoted the proliferation and motility of glioma cells (45).…”

Section: Discussionmentioning

confidence: 99%

“…Silencing of LINC01094 increased radiosensitivity of ccRCC cells through the microRNA (miR/miRNA)-577/checkpoint kinase 2/forkhead box M1 axis (18). Reports showed that LINC01094 and solute carrier family 2 member 3 (SLC2A3) were highly expressed, while miR-184 was lowly expressed, in ccRCC; LINC01094 regulated SLC2A3 by sponging miR-184, and affected the proliferation, migration and invasion of ccRCC cells (17). Analysis of the Gene Expression Profiling Interactive Analysis (GEPIA) database indicated that LINC01094 was significantly increased in OC (19), but its functional role in OC remained unclear.…”

Section: Linc01094 Promotes the Invasion Of Ovarian Cancer Cells And Regulates The Wnt/β-catenin Signaling Pathway By Targeting Mir-532-3mentioning

confidence: 99%

“…In addition, it has been reported that a number of lncRNAs are closely related to the metastatic behavior of a variety of tumor cells (12)(13)(14)(15). Long intergenic non-protein coding RNA 1094 (LINC01094) was indicated to be an oncogenic gene in renal cell carcinoma and glioma cells, involved in regulating cell migration and invasion (16,17). LINC01094 was reported to be upregulated in clear cell renal cell carcinoma (ccRCC) cell lines and to promote…”

Section: Introductionmentioning

confidence: 99%

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LINC01094 promotes the invasion of ovarian cancer cells and regulates the Wnt/β‑catenin signaling pathway by targeting miR‑532‑3p

Chen

Liu

et al. 2021

Exp Ther Med

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Long non-coding RNAs (lncRNAs) participate in the development of ovarian cancer (OC). The present study aimed to explore the roles of long intergenic non-protein coding RNA 1094 (LINC01094) in OC. LINC01094 and microRNA (miR)-532-3p expression in OC tissues and cells were measured using reverse transcription-quantitative PCR. Cell migration and invasion were detected using wound healing assays and Transwell assays, respectively. The binding of LINC01094 or β-catenin to miR-126-5p was detected using a Dual-luciferase reporter assay, and protein expression was confirmed using western blot analysis. The expression level of LINC01094 in patients with OC was higher in OC tissues compared with in adjacent tissues, and LINC01094 was upregulated in OC cell lines. In addition, LINC01094 overexpression promoted the viability, migration, invasion and cell cycle progression of OC cells, and inhibited OC cell apoptosis. Moreover, LINC01094 negatively regulated miR-532-3p in OC cells and tissues. miR-532-3p overexpression decreased the viability, migration, invasion and cell cycle progression of OC cells alongside downregulation of Wnt/β-catenin signaling pathway protein expression, as well as increasing OC cell apoptosis. Inhibition of LINC01094 with small interfering (si)-LINC01094 and overexpression of LINC01094 respectively reversed the effect of miR-532-3p inhibitor and mimics on OC cells. miR-532-3p could directly target β-catenin, and miR-532-3p inhibitor increased β-catenin expression, while si-LINC01094 attenuated this effect. In addition, LINC01094 overexpression promoted tumor growth in vivo by regulating miR-532-3p. Taken together, LINC01094 promoted the growth, migration, invasion and Wnt/β-catenin signaling pathway expression of OC cells by modulating miR-532-3p.

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“…MIR3142HG is a critical regulator of the inflammatory response, and the attenuated expression of MIR3142HG/miR-146a contributes to the reduced inflammatory response in IPF fibroblast ( Hadjicharalambous et al, 2018 ). As for LINC01094, several studies reported that it is a pro-tumorigenic lncRNA, and microRNA-184 ( Xu H. et al, 2020 ), miR-126-5p ( Li and Yu, 2020 ), miR-577 ( Xu J. et al, 2020 ), miR-330-3p ( Zhu et al, 2020 ), and miR-224-5p ( Jiang et al, 2020 ) were identified as its targets. The role of ABALON, AC004009-2, and LINC01711 has not been explored by biological assays, providing directions and clues for future research.…”

Section: Discussionmentioning

confidence: 99%

Identification of an Immune-Related LncRNA Signature in Gastric Cancer to Predict Survival and Response to Immune Checkpoint Inhibitors

Ding

Han

et al. 2021

Front. Cell Dev. Biol.

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Immune microenvironment in gastric cancer is closely associated with patient’s prognosis. Long non-coding RNAs (lncRNAs) are emerging as key regulators of immune responses. In this study, we aimed to construct a prognostic model based on immune-related lncRNAs (IRLs) to predict the overall survival and response to immune checkpoint inhibitors (ICIs) of gastric cancer (GC) patients. The IRL signature was constructed through a bioinformatics method, and its predictive capability was validated. A stratification analysis indicates that the IRL signature can distinguish different risk patients. A nomogram based on the IRL and other clinical variables efficiently predicted the overall survival of GC patients. The landscape of tumor microenvironment and mutation status partially explain this signature’s predictive capability. We found the level of cancer-associated fibroblasts, endothelial cells, M2 macrophages, and stroma cells was high in the high-risk group, while the number of CD8+ T cells and T follicular helper cells was high in the low-risk group. Immunophenoscore (IPS) is validated for ICI response, and the IRL signature low-risk group received higher IPS, representing a more immunogenic phenotype that was more inclined to respond to ICIs. In addition, we found RNF144A-AS1 was highly expressed in GC patients and promoted the proliferation, migration, and invasive capacity of GC cells. We concluded that the IRL signature represents a novel useful model for evaluating GC survival outcomes and could be implemented to optimize the selection of patients to receive ICI treatment.

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Long Non-coding RNA LINC01094 Promotes the Development of Clear Cell Renal Cell Carcinoma by Upregulating SLC2A3 via MicroRNA-184

Cited by 26 publications

References 29 publications

Construction of a Novel Prognostic Immune-Related LncRNA Risk Model for Gastric Cancer

Construction of a Novel Prognostic Immune-Related LncRNA Risk Model for Gastric Cancer

LINC01094 promotes the invasion of ovarian cancer cells and regulates the Wnt/β‑catenin signaling pathway by targeting miR‑532‑3p

Identification of an Immune-Related LncRNA Signature in Gastric Cancer to Predict Survival and Response to Immune Checkpoint Inhibitors

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