Long non-coding RNA LINC01503 promotes the progression of hepatocellular carcinoma via activating MAPK/ERK pathway

Wang, Mu-Ru; Fang, Dan; Di, Muping; Guan, Jia‐Lun; Wang, Ge; Sheng, Jiaqi; Tian, Dean; Li, Peiyuan

doi:10.7150/ijms.45256

Cited by 19 publications

(25 citation statements)

References 30 publications

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“…Transcripts with no apparent protein-coding potential, which are larger than 200 nucleotides, are defined as long noncoding RNAs (lncRNAs) [3]. Increasing evidence has demonstrated that lncRNAs play essential roles in the initiation and progression of human cancers via regulating several cellular behaviors, including proliferation, apoptosis, migration, invasion, and glycolysis [4,5]. Our group Ivyspring International Publisher has previously identified several HCC-related lncRNAs.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA FIRRE contributes to the proliferation and glycolysis of hepatocellular carcinoma cells by enhancing PFKFB4 expression

Shen

Ding

et al. 2021

J. Cancer

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Recent reports show that long noncoding RNA (lncRNA) FIRRE contributes to the proliferation, apoptosis resistance, and invasion of colorectal cancer and diffuse large B-cell lymphoma. However, the biological function of FIRRE in hepatocellular carcinoma (HCC) remains unknown. Here, we disclosed that the FIRRE level was frequently increased in HCC compared to nontumor tissues. Compared with normal liver cells, we also confirmed the upregulated level of FIRRE in HCC cells. Notably, the FIRRE high expression was related to malignant clinical features, including advanced TNM stage and tumor size ≥5 cm, and conferred to worse survival of HCC. Functionally, FIRRE knockdown repressed the proliferation and glycolysis of HCCLM3 cells. Overexpression of FIRRE strengthened Huh7 cell proliferation and glycolysis. Notably, FIRRE positively regulated the glycolic enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) expression in HCC cells. PFKFB4 was highly expressed and positively associated with FIRRE level in HCC tissues. The upregulated expression of PFKFB4 was associated with high tumor grade and advanced TNM stage. TCGA data revealed that the PFKFB4 high expression indicated a poor prognosis of HCC. Mechanistically, modulating FIRRE level did not affect the stability of PFKFB4 mRNA. FIRRE was mainly distributed in HCC cells' nucleus and promoted PFKFB4 transcription and expression via cAMP-responsive element-binding protein (CREB). PFKFB4 could abolish the effects of FIRRE knockdown on HCC cell proliferation and glycolysis. To conclude, the highly expressed FIRRE facilitated HCC cell proliferation and glycolysis by enhancing CREB-mediated PFKFB4 transcription and expression.

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Section: Introductionmentioning

confidence: 99%

Long noncoding RNA FIRRE contributes to the proliferation and glycolysis of hepatocellular carcinoma cells by enhancing PFKFB4 expression

Shen

Ding

et al. 2021

J. Cancer

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“…Upregulated expression of lncRNA LASTR was found in several epithelial tumors and could facilitate cancer cell fitness in hypoxic breast cancer through SART3 ( De Troyer et al, 2020 ). LINC01503 is involved in a variety of malignancies, including hepatocellular carcinoma, cholangio-carcinoma, non-small-cell lung cancer, cervical cancer, and gastric cancer ( Qu et al, 2019 ; Shen et al, 2020 ; Wang et al, 2020 ; Zhang et al, 2020 ; Feng et al, 2021 ; Ma et al, 2021 ). Wu et al (2021) reported that the overexpression of LINC00460 in pancreatic ductal adenocarcinoma could promote tumor aggressiveness by targeting miR-491-5p, conferring a poor clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Identification of a ferroptosis-related long noncoding RNA signature with a prognostic value in adrenocortical carcinoma

et al. 2022

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Background: Adrenocortical carcinoma (ACC) is an uncommon endocrine malignancy associated with poor clinical outcome. As a novel form of cell death, ferroptosis is reliant on the accumulation of iron and reactive oxygen species and is involved in the pathogenesis of various tumors, including ACC. Our study aimed to identify and characterize the prognostic ferroptosis-related lncRNA signature (FerRLSig) in ACC.Methods: A regulatory network of ferroptosis-related lncRNAs (FerRLs) and mRNAs was constructed based on The Cancer Genome Atlas (TCGA). Univariate and multivariate Cox regression assays were performed to construct the FerRLSig.Results: Twenty-four FerRLs were identified in the prognostic model, and the high-risk FerRLSig was related to the worse overall survival (OS) in ACC [hazard ratio (HR): 1.936 (1.484–2.526), p < 0.001]. The area under the curve (AUC) value of the FerRLSig was 0.936 according to the receiver operating characteristic (ROC) analyses, superior to other traditional clinicopathological features, further supported the utility in prognosis prediction of ACC. We further established a prognostic nomogram combining clinical factors with the FerRLSig, which showed favorable efficacy for survival prediction. Next, gene set enrichment analysis (GSEA) revealed that gene sets were involved in many immune regulatory biological processes related to malignancies. T-cell function of type II INF response and the immune checkpoints, including CD40, CD276, IDO2, NRP1, and CD80, were expressed with a significant difference between the low- and high-risk groups.Conclusion: This study offered new insights into the pathogenesis of ACC. The novel FerRLSig could be useful in predicting survival and may provide information of immunological research and treatment for ACC patients.

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“…Dong et al [ 36 ] further demonstrated that LINC00899 promoted cell proliferation and inhibited apoptosis in AML cells. LINC01503 expression level was significantly up-regulated, correlated with poor prognosis and conferred oncogenic functions in glioma [ 37 ], hepatocellular carcinoma [ 38 ], gastric cancer [ 39 ] and especially colorectal cancer [ 40 ]. Silencing of PRKAG2-AS1 alleviated castration-resistant prostate cancer (CRPC) tumor growth, showing repression of androgen receptor (AR) and AR variant expression [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Integrative analysis of ceRNA network reveals functional lncRNAs associated with independent recurrent prognosis in colon adenocarcinoma

Mao

Jiang

et al. 2021

Cancer Cell Int

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Background Long non-coding RNAs (lncRNAs), acting as competing endogenous RNA (ceRNA) have been reported to regulate the expression of targeted genes by sponging miRNA in colon adenocarcinoma (COAD). Methods However, their potential implications for recurrence free survival prognosis and functional roles remains largely unclear in COAD. In this study, we downloaded the TCGA dataset (training dataset) and GSE39582 (validation dataset) of COAD patients with prognostic information. Results A total of 411 differentially expressed genes (DElncRNAs: 12 downregulated and 43 upregulated), 18 DE miRNAs (9 downregulated and 9 upregulated) and 338 DEmRNAs (113 downregulated and 225 upregulated) were identified in recurrence samples compared with non-recurrence samples with the thresholds of FDR < 0.05 and |log2FC|> 0.263. Based on six signature lncRNAs (LINC00899, LINC01503, PRKAG2-AS1, RAD21-AS1, SRRM2-AS1 and USP30-AS1), the risk score (RS) system was constructed. Two prognostic clinical features, including pathologic stage and RS model status were screened for building the nomogram survival model. Moreover, a recurrent-specific ceRNA network was successfully constructed with 2 signature lncRNAs, 4 miRNAs and 113 mRNAs. Furthermore, we further manifested that SRRM2-AS1 predicted a poor prognosis in COAD patients. Furthermore, knockdown of SRRM2-AS1 significantly suppressed cell proliferation, migration, invasion and EMT markers in HT-29 and SW1116 cells. Conclusion These identified novel lncRNA signature and ceRNA network associated with recurrence prognosis might provide promising therapeutic targets for COAD patients.

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Long non-coding RNA LINC01503 promotes the progression of hepatocellular carcinoma via activating MAPK/ERK pathway

Cited by 19 publications

References 30 publications

Long noncoding RNA FIRRE contributes to the proliferation and glycolysis of hepatocellular carcinoma cells by enhancing PFKFB4 expression

Long noncoding RNA FIRRE contributes to the proliferation and glycolysis of hepatocellular carcinoma cells by enhancing PFKFB4 expression

Identification of a ferroptosis-related long noncoding RNA signature with a prognostic value in adrenocortical carcinoma

Integrative analysis of ceRNA network reveals functional lncRNAs associated with independent recurrent prognosis in colon adenocarcinoma

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