Long non-coding RNA LINC01559 exerts oncogenic role via enhancing autophagy in lung adenocarcinoma

Abstract

Background Long non-coding RNAs (lncRNAs) have been verified to play fatal role in regulating the progression of lung adenocarcinoma (LUAD). Although lncRNAs play important role in regulating the autophagy of tumor cells, the function and molecular mechanism of LINC01559 in regulating lung cancer development remain to be elucidated. Method and materials In this study, we used bioinformatics to screen out autophagy-related lncRNAs from TCGA-LUAD repository. Then the least absolute shrinkage and selection operator (LASSO) regression was applied to establish the signature of autophagy-related lncRNAs so that clinical characteristics and survival in LUAD patients be evaluated. Finally, we selected the most significant differences lncRNA, LINC01559, to verify its function in regulating LUAD progression in vitro. Results We found high expression of LINC01559 indicates lymph node metastasis and poor prognosis. Besides, LINC01559 promotes lung cancer cell proliferation and migration in vitro, by enhancing autophagy signal pathway via sponging hsa-miR-1343-3p. Conclusion We revealed a novel prognostic model based on autophagy-related lncRNAs, and provide a new therapeutic target and for patients with lung adenocarcinoma named LINC01559.

Upregulation of hsa_circ_0002003 promotes hepatocellular carcinoma progression

“…According to the genome-wide miRNA expression profiling dataset GSE76903 [ 20 ], only hsa-miR-1343-3p was selected as a candidate miRNA for further research. Recent studies have found that LINC01559 promotes lung cancer cell proliferation and migration in vitro by enhancing the autophagy signaling pathway via sponging hsa-miR-1343-3p [ 29 ]. In HCC, the lncRNA ASMTL-AS1 acts as a carcinogen, competing with hsa-miR-1343-3p that suppressing LAMC1 [ 30 ].…”

A finger in every pie – The versatility of chemokines

“…LINC01559 is an novel, intergenic, long non-coding RNA (lncRNA). So far it has been shown to take part in promoting gastric cancer as well as the progression of pancreatic cancer, lung cell proliferation and migration through enhancing autophagy [ 28 ].…”

Decoding the regulatory landscape of lncRNAs as potential diagnostic and prognostic biomarkers for gastric and colorectal cancers

“…SA treatment changes the function of LINC00152 [ 222 ] PICART1 Down MAPK The upregulation of PICART1 reduces the pERK expression, whereas PICART1 silencing reverses the expression of p-ERK [ 223 ] AOC4P Up MAPK The suppression of AOC4P reduces the expression of ERK1, JNK, and p38 [ 224 ] GC linc00483 Up MAPK The suppression of Linc00483 reduces the expression of c-Jun without affecting the p-Jnk, p53, and p-p38 expression [ 225 ] CRNDE Up PI3K/AKT The repression of CRNDE significantly downregulates pPI3K and p-Akt expression [ 226 ] LINC01559 Up PI3K/AKT The suppression of LINC01559 reduces the expression of PGK1, p-PI3K, p-AKT, and mTOR. IGF-1 treatment (PI3K activator) significantly reverses the LINC01559 knockdown induced phosphorylation of PI3K, AKT, and mTOR [ 227 ] PICART1 Down PI3K/AKT The upregulation of PICART1 reduces p-AKT expression, whereas PICART1 inhibition increases p-AKT expression [ 223 ] LINC01419 UP PI3K/AKT The suppression of LINC01419 in GC cells reduces the expression of p-AKT1 and p-mTOR but does not affect their total levels [ 228 ] LOC101928316 Down …”