Long Non-Coding RNA LINC01559 Exerts Oncogenic Role Via Enhancing Autophagy in Lung Adenocarcinoma

Abstract

Background: Long non-coding RNAs (lncRNAs) have been verified to play fatal role in regulating the progression of lung adenocarcinoma (LUAD). Although lncRNAs play important role in regulating the autophagy of tumor cells, the function and molecular mechanism of LINC01559 in regulating lung cancer development remain to be elucidated. Method and materials: In this study, we used bioinformatics to screen out autophagy-related lncRNAs from TCGA-LUAD repository, and the least absolute shrinkage and selection operator (LASSO) regression was applied to establish the clinical characteristics and survival of autophagy-related lncRNAs in LUAD patients was analyzed. Finally, we selected the most significant differences lncRNA, LINC01559, to verify its function in regulating LUAD progression.Results: we found high expression of LINC01559 indicates lymph node metastasis and poor prognosis. Besides, LINC01559 promotes lung cancer cell proliferation and migration in vitro, by enhancing autophagy signal pathway. Conclusion: We revealed a novel prognostic model based on autophagy-related lncRNAs, and provide a new therapeutic target and for patients with lung adenocarcinoma with LINC01559.

Upregulation of hsa_circ_0002003 Promotes Hepatocellular Carcinoma Progression

“…According to the genome-wide miRNA expression pro le data (average normalized count ≥ 1), in the GSE76903 dataset, among the above 14 miRNAs, only hsa-miR-1343-3p had an average expression level greater than 1. Recent studies have found that LINC01559 promotes lung cancer cell proliferation and migration in vitro by enhancing the autophagy signaling pathway via sponging hsa-miR-1343-3p [29]. However, the role of hsa-miR-1343-3p in HCC has not been reported.…”