Long non‐coding RNA Miat mediates cross-talk between the kidneys and hippocampus in the rat model of acute kidney injury

Abstract

Acute kidney injury (AKI) is a complex disorder with high morbidity and mortality rate, especially when associated with multi-organ dysfunction syndrome in critically ill patients (Doi and Rabb, 2016). Renal ischemia/reperfusion, the most common cause of acute kidney injury, occurs in situations such as myocardial infarction, stroke, major surgeries and renal transplantation (Salvadori et al., 2015). AKI is not only locally limited to the kidney, but also affects remote organs such as the heart, lung, liver and brain that worsens outcomes (Shiao et al., 2015). The most important remote organic syndrome of acute or chronic renal failure is uremic encephalopathy, although the symptoms are more pronounced and