Long non-coding RNA MINCR promotes gallbladder cancer progression through stimulating EZH2 expression

Wang, Shou-Hua; Yang, Yong; Wu, Xiaodi; Zhang, Mingdi; Weng, Mingzhe; Zhou, Di; Wang, Jiandong; Quan, Zhiwei

doi:10.1016/j.canlet.2016.06.019

Cited by 56 publications

(42 citation statements)

References 53 publications

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“…This observation is especially interesting, as (over)expression of certain ceRNA species might represent an important mechanism to regulate the protein levels of epigenetic regulators such as EZH2 in BTC [97]. A similar mechanism was published by Shou-Hua et al: here, the authors demonstrated that the ceRNA MINCR sponges miR-26a-5p, another negative regulator of EZH2, which again resulted in upregulated EZH2-expression accompanied by enhanced proliferation of BTC cells [84]. Guide-lncRNAs directly interact with EZH2 and guide EZH2 (as enzymatic part of the polycomb repressive complex 2) to specific target gene promoters for epigenetic gene silencing.…”

Section: Ezh2-a Major Target Of Lncrna-based Regulationsupporting

confidence: 65%

Long Non-Coding RNAs in Biliary Tract Cancer—An Up-to-Date Review

Bekric

Neureiter

Ritter

et al. 2020

JCM

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The term long non-coding RNA (lncRNA) describes non protein-coding transcripts with a length greater than 200 base pairs. The ongoing discovery, characterization and functional categorization of lncRNAs has led to a better understanding of the involvement of lncRNAs in diverse biological and pathological processes including cancer. Aberrant expression of specific lncRNA species was demonstrated in various cancer types and associated with unfavorable clinical characteristics. Recent studies suggest that lncRNAs are also involved in the development and progression of biliary tract cancer, a rare disease with high mortality and limited therapeutic options. In this review, we summarize current findings regarding the manifold roles of lncRNAs in biliary tract cancer and give an overview of the clinical and molecular consequences of aberrant lncRNA expression as well as of underlying regulatory functions of selected lncRNA species in the context of biliary tract cancer.

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Section: Ezh2-a Major Target Of Lncrna-based Regulationsupporting

confidence: 65%

Long Non-Coding RNAs in Biliary Tract Cancer—An Up-to-Date Review

Bekric

Neureiter

Ritter

et al. 2020

JCM

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“…RNA FISH was performed as described previously elsewhere with minor modifications42. The probes of in situ hybridization for H19 were synthesized from GoodBio (Wuhan, China).…”

Section: Methodsmentioning

confidence: 99%

Hypoxia induces H19 expression through direct and indirect Hif-1α activity, promoting oncogenic effects in glioblastoma

Nie

et al. 2017

Sci Rep

105

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H19 expression is elevated in many human tumors including glioblastomas, suggesting an oncogenic role for the long noncoding RNA; yet the upregulation of H19 in glioblastomas remains unclear. Here we report that hypoxia significantly stimulated H19 expression in glioblastoma cell lines, which was related to hypoxia-inducible factors 1α (Hif-1α). Hif-1α promoted H19 expression in U87 and U251 cells. Meanwhile PTEN is an advantageous factor to affect H19 expression, through attenuating Hif-1α stability. Hif-1α also positively correlates with H19 in human glioblastoma samples depending on PTEN status. ChIP and luciferase reporter assays showed that Hif-1α induced H19 transcription through directly binding to the H19 promoter. Furthermore, Hif-1α upregulated specific protein 1 (SP1) expression in glioblastomas cells in vitro and in vivo, and SP1 also strongly interacted with the H19 promoter to promote H19 expression under hypoxia. We also showed that H19 acts as a molecular sponge that binds miR-181d, relieving inhibition of β-catenin expression. Therefore, H19 participates in hypoxia-driven migration and invasion in glioblastoma cells. In summary, our results uncover the mechanisms that stimulate H19 expression under hypoxia to promote malignant effects in glioblastomas and suggest H19 might be a promising therapeutic target.

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“…Although the precise function of MINCR has not been fully elucidated yet, we found clear evidence that MINCR is able to control normal cell cycle progression and it is interfering with the ability of MYC to transactivate a set of genes involved in cell cycle progression. Accordingly the group of Quan found that MINCR knock-down was able to strongly reduce the ability of gallbladder cancer cells to form tumors in nude mice [ 35 ].…”

Section: Long Non-coding Rnas (Lncrnas) Expression Regulated By Mymentioning

confidence: 99%

lncRNAs and MYC: An Intricate Relationship

Iaccarino

2017

IJMS

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Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression networks, acting either at the transcriptional level, by influencing histone modifications, or at the post-transcriptional level, by controlling mRNA stability and translation. Among the gene expression networks known to influence the process of oncogenic transformation, the one controlled by the proto-oncogene MYC is one of the most frequently deregulated in cancer. In B-cell lymphomas, the MYC gene is subject to chromosomal rearrangements that result in MYC overexpression. In many other cancers, the region surrounding MYC is subject to gene amplification. MYC expression is also controlled at the level of protein and mRNA stability. Neoplastic lesions affecting MYC expression are responsible for a drastic change in the number and the type of genes that are transcriptionally controlled by MYC, depending on differential promoter affinities. Transcriptome profiling of tumor samples has shown that several lncRNAs can be found differentially regulated by MYC in different cancer types and many of them can influence cancer cell viability and proliferation. At the same time, lncRNAs have been shown to be able to control the expression of MYC itself, both at transcriptional and post-transcriptional levels. Given that targeting the MYC-dependent transcriptional program has the potential to reach broad anticancer activity, molecular dissection of the complex regulatory mechanisms governing MYC expression will be crucial in the future for the identification of novel therapeutic strategies.

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Long non-coding RNA MINCR promotes gallbladder cancer progression through stimulating EZH2 expression

Cited by 56 publications

References 53 publications

Long Non-Coding RNAs in Biliary Tract Cancer—An Up-to-Date Review

Long Non-Coding RNAs in Biliary Tract Cancer—An Up-to-Date Review

Hypoxia induces H19 expression through direct and indirect Hif-1α activity, promoting oncogenic effects in glioblastoma

lncRNAs and MYC: An Intricate Relationship

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