Long non-coding RNA POLR2E gene polymorphisms increased the risk of prostate cancer in a sample of the Iranian population

Sattarifard, Hedieh; Hashemi, Mohammad; Hassanzarei, Shekoufeh; Basiri, Abbas; Narouie, Behzad; Ghavami, Saeid

doi:10.1080/15257770.2017.1391394

Cited by 12 publications

(16 citation statements)

References 52 publications

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“…50 POLR2E genetic polymorphisms were proposed to increase prostate cancer risk. 51 Another study also found that it was correlated with the risk of prostate cancer but not lung cancer. 52 Besides, Kang et al 53 confirm our results, more cohorts or case-control studies of glioma on these SNPs are necessary.…”

Section: Discussionmentioning

confidence: 99%

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Impact of four lncRNA polymorphisms (rs2151280, rs7763881, rs1136410, and rs3787016) on glioma risk and prognosis: A case‐control study

Deng

Zhou

et al. 2019

Molecular Carcinogenesis

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Long noncoding RNA (lncRNA) polymorphisms are reportedly in connection with tumor susceptibility and prognosis. Glioma is one of the most aggressive and common cancers of the central nervous system. This study aimed to investigate the relationship between four lncRNA variants and glioma susceptibility and prognosis in a Chinese Han population. Sequenom Mass‐ARRAY was used to genotype 605 patients with glioma and 1300 cancer‐free individuals. Odds ratios or hazard ratios and related 95% confidence intervals were calculated to estimate the correlations. Logistic and Cox regression models, log‐rank tests, and Kaplan‐Meier curves were used for the statistical analysis. Six inheritance models showed that ANRIL rs2151280 variant genotype (A>G) was related to the susceptibility of glioma, while the other three lncRNAs showed no association. Patients treated with temozolomide or nimustine had better progression‐free survival (PFS) and overall survival (OS) than those treated with platinum. Besides, patients aged older than 40 years showed a poorer OS. The Cox multivariate analysis revealed that the rs1136410 GG genotype (A>G) was beneficial for OS and PFS. The Kaplan‐Meier analyses indicated that rs1136410 A>G and the rs7763881 A>C were associated with longer OS. ANRIL rs2151280 variant genotype might increase susceptibility of glioma. In addition, PARP1 rs1136410 variant genotype could be beneficial for the overall survival of patients with glioma. More research data are needed to further validate our results.

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Section: Discussionmentioning

confidence: 99%

“…POLR2E , located at 19p13, produces messenger RNA . POLR2E genetic polymorphisms were proposed to increase prostate cancer risk . Another study also found that it was correlated with the risk of prostate cancer but not lung cancer .…”

Section: Discussionmentioning

confidence: 99%

Impact of four lncRNA polymorphisms (rs2151280, rs7763881, rs1136410, and rs3787016) on glioma risk and prognosis: A case‐control study

Deng

Zhou

et al. 2019

Molecular Carcinogenesis

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“…One multi-center article which included as 3 independent studies enlisted population from the same regions. Consequently, 6 casecontrols (5650 cases and 6325 controls) and 4 case-control (833 cases and 869 controls) separately were collected to assess the association of rs3787016 and rs3746444 with PCa risk [12][13][14][15][18][19][20][21] ( Fig. 1).…”

Section: Literature Searchmentioning

confidence: 99%

“…Located at 16p13 encodes a subunit of RNA polymerase II, the POLR2E LncRNA gene was in charge of producing messenger RNA (mRNA) [10,11]. Rare studies have identi ed the impact of rs3787016 polymorphism on the risk of PCa [12][13][14][15], which was the same as esophageal squamous cell carcinoma (ESCC) [16], while the ndings were inconsistent and con icting. Notwithstanding, hardly any studies evaluated the association between these SNPs with the risk of PCa as well as quite a few investigations have been reported the functional signi cant effects of nucleotide changes in genes encoding of LncRNA POLR2E and MiRNA-499 [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Notwithstanding, hardly any studies evaluated the association between these SNPs with the risk of PCa as well as quite a few investigations have been reported the functional signi cant effects of nucleotide changes in genes encoding of LncRNA POLR2E and MiRNA-499 [6,7]. While in the present investigation, we aimed to estimate the association between LncRNA POLR2E and MiRNA-499 gene polymorphisms with the risk of PCa patients [12][13][14][15][18][19][20][21], owing to the inconsistencies regarding the impact of LncRNA or MiRNA gene polymorphisms on prostate cancer affectability.…”

Section: Introductionmentioning

confidence: 99%

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Association of rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E with Prostate Cancer: an updated meta-analysis and systematic review

Liu

Wang

et al. 2020

Preprint

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Background It has been proved that a significant proportion of prostate cancer diagnoses may be associated with a strong hereditary component. Micro-RNAs and Long Non-coding RNAs are a group of a noncoding small molecule, which play critical roles in signalling pathways, metabolism, apoptosis and cancer development. Exercising a meta-analysis to examine the relationship between rs3746444, rs3787016 and prostate cancer (PCa) risk was the main objective of our study. Results 10 case-control studies were included, while 6 on rs3787016 and 4 on rs3746444. On the whole, the genotypes carrying the T allele, in which were verified an increased risk between rs3787016 and PCa risk.( T vs C: odds ratio(OR) = 1.802, 95% CI 1.015–3.198, P value of heterogeneity(PH) = 0.00%; CT vs CC: OR = 1.179,95% CI 1.091–1.275, PH = 0.41; TT vs CC: .OR = 1.418, 95% CI 1.229–1.636, PH= 0.961; TT + CT vs CC: OR = 1.216, 95% CI 1.129–1.310, PH= 0.408; TT vs CT + CC: OR = 1.328, 95%CI 1.159–1.521, PH = 0.987). A vital relevance was performed by this meta-analysis in three models between rs3746444 and PCa risk, in which a tendency of increased PCa risk could be found (C vs T: OR = 1.197, 95% CI 1.035–1.384, PH= 0.837; CC vs TT: OR = 1. 137, 95% CI 0.813–1.590, PH = 0.392; CC + CT vs TT: OR = 1.426, 95% CI 1.166–1.743, PH= 0.406.). Conclusion Our findings proposed that rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E polymorphisms increased the risk of developing PCa. Further functional studies are warranted to reveal the role of the polymorphism in carcinogenesis.

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LncRNA polymorphisms and urologic cancer risk

Abdi

Latifi‐Navid

2022

Environ and Mol Mutagen

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Urologic cancers involve nearly one-quarter of all cancers and include the prostate, bladder, and kidney cancers. Long non-coding RNAs (LncRNAs) are expressed in a tissue-specific manner and affect cell proliferation, apoptosis, and differentiation.LncRNAs expression is misregulated in urologic cancers, as their aberrant expression may make them capable of being utilized in the diagnosis, prognosis, and treatment of cancers. LncRNAs polymorphisms can affect their structure, expression, and function by interfering with the associated target mRNAs. As a result, lncRNA polymorphisms may be linked to the mechanism driving cancer susceptibility. Therefore, SNPs in lncRNAs may be a beneficial biomarker for early diagnosis and prognosis of cancers, as they affect lncRNA role in tumorigenesis and cancer progression. Moreover, the genetic heredity of lncRNA SNPs affects the personal therapeutic response to drugs. In this study, the lncRNAs polymorphism is summarized in relation to urologic cancers. It is proposed that lncRNA-related polymorphisms, as an individual or combined genotypes, can predict urologic cancer risk, even clinical and prognostic outcomes. However, large-scale population-based prospective studies and comprehensive meta-analyses should be conducted to validate and use these lncRNAs SNPs as the indicators of urologic cancers. Future research should examine the function of these SNPs to explain their associations with urologic cancers.

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Long non-coding RNA POLR2E gene polymorphisms increased the risk of prostate cancer in a sample of the Iranian population

Cited by 12 publications

References 52 publications

Impact of four lncRNA polymorphisms (rs2151280, rs7763881, rs1136410, and rs3787016) on glioma risk and prognosis: A case‐control study

Impact of four lncRNA polymorphisms (rs2151280, rs7763881, rs1136410, and rs3787016) on glioma risk and prognosis: A case‐control study

Association of rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E with Prostate Cancer: an updated meta-analysis and systematic review

LncRNA polymorphisms and urologic cancer risk

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