Long non‑coding RNA small nucleolar RNA host gene 7 is upregulated and promotes cell proliferation in thyroid cancer

Chen, Li; Zhu, Jing; Zhang, Ling‐Jie

doi:10.3892/ol.2019.10782

Cited by 5 publications

(5 citation statements)

References 44 publications

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“…In addition, down-regulated MEG3 could affect OA progression through miR-16/SMAD7 axis [31]. lncRNA SNHG7 was reported to as an oncogene in several cancers [17,18,20]. However, contrary to the previous study [21], we found that SNHG7 expression was reduced in OA tissues compared with normal tissues and the level of IL-1β was increased in OA serum compared with normal serum.…”

Section: Discussioncontrasting

confidence: 58%

“…Notably, studies have reported that lncR-NAs may acts as competitive RNA which competitively binds to target miRNAs to indirectly regulate mRNAs [15,16]. lncRNA SNHG7 (small nucleolar RNA host gene 7) has been demonstrated to participate in cell development and progression of many diseases, especially in cancers [17][18][19]. Previous studies showed that SNHG7 was upregulated in several cancers, such as glioblastoma, colorectal cancer, gastric cancer and esophageal cancer [19,20].…”

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confidence: 99%

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LncRNA SNHG7/miR-34a-5p/SYVN1 axis plays a vital role in proliferation, apoptosis and autophagy in osteoarthritis

et al. 2020

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Background: Osteoarthritis (OA) is one of the most common rheumatic diseases of which clinical symptoms includes swelling, synovitis and inflammatory pain, affect patients' daily life. It was reported that non-coding RNAs play vital roles in OA. However, the regulation mechanism of ncRNA in OA pathogenesis has not been fully elucidated. Methods: The expression of SNHG7, miR-34a-5p and SYVN1 was detected using qRT-PCR in tissues, serum and cells. The protein expression of SYVN1, PCNA, cleavage-caspase 3, beclin1 and LC3 were measured using western blot. The RNA immunoprecipitation (RIP), RNA pulldown, and luciferase reporter assays were used to verify the relationship between SNHG7, miR-34a-5p and SYVN1. The MTT and flow cytometry assay was performed to detected cell proliferation and cell apoptosis respectively. Results: In this study, SNHG7 and SYVN1 expression were down-regulated, but miR-34a-5p was up-regulated in OA tissues and IL-1β treated cells compared with normal tissues and chondrocyte. Functional investigation revealed that up-regulated SNHG7 or down-regulated miR-34a-5p could promote cell proliferation and inhibit cell apoptosis and autophagy in OA cells. More than that, RIP, pulldown and luciferase reporter assay was applied to determine that miR-34a-5p was a target miRNA of SNHG7 and SYVN1 was a target mRNA of miR-34-5p. Rescue experiments showed that overexpression of miR-34a reversed high expression of SNHG7-mediated suppression of apoptosis and autophagy as well as promotion of proliferation, while its knockdown inhibited cell apoptosis and autophagy and promoted cell proliferation which could be impaired by silencing SYVN1. In addition, SNHG7 regulated SYVN1 through sponging miR-34a-5p. Conclusion: SNHG7 sponged miR-34a-5p to affect cell proliferation, apoptosis and autophagy through targeting SYVN1 which provides a novel sight into the pathogenesis of OA.

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Section: Discussioncontrasting

confidence: 58%

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confidence: 99%

LncRNA SNHG7/miR-34a-5p/SYVN1 axis plays a vital role in proliferation, apoptosis and autophagy in osteoarthritis

et al. 2020

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“…The high expression levels of SNHG7 are correlated with advanced stages (III and IV) and shorter survival times in of thyroid cancer patients. Their funding showed that SNHG7 knockdown inhibits the cell proliferation and cell cycle progression of ATC cell line in vitro [ 24 ]. The molecular mechanism of ATC caused by upregulation of SNHG7 still remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Molecular mechanisms of long non-coding RNAs in anaplastic thyroid cancer: a systematic review

et al. 2020

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Background anaplastic thyroid cancer (ATC) is one of the most lethal and aggressive cancers. Evidence has shown that the tumorigenesis of ATC is a multistep process involving the accumulation of genetic and epigenetic changes. Several studies have suggested that long non-coding RNAs (lncRNAs) may play an important role in the development and progression of ATC. In this article, we have collected the published reports about the role of lncRNAs in ATC. Methods “Scopus”, “Web of Science”, “PubMed”, “Embase”, etc. were systematically searched for articles published since 1990 to 2020 in English language, using the predefined keywords. Results 961 papers were reviewed and finally 33 papers which fulfilled the inclusion and exclusion criteria were selected. Based on this systematic review, among a lot of evidences on examining the function of lncRNAs in thyroid cancer, there are only a small number of studies about the role of lncRNAs and their molecular mechanisms in the pathogenesis of ATC. Conclusions lncRNAs play a crucial role in regulation of different processes involved in the development and progression of ATC. Currently, just a few lncRNAs have been identified in ATC that may serve as prognosis markers such as GAS5, MIR22HG, and CASC2. Also, because of the dysregulation of Klhl14-AS, HOTAIRM1, and PCA3 during ATC development and progression, they may act as therapeutic targets. However, for most lncRNAs, only a single experiment has evaluated the expression profile in ATC tissues/cells. Therefore, further functional studies and expression profiling is needed to resolve this limitation and identify novel and valid biomarkers.

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“…19 SNHG7 is also markedly upregulated in thyroid cancer samples, with high SNHG7 expression associated with shorter survival times. 20 Indeed, SNHG7 knockdown leads to a suppression of thyroid cancer cell proliferation and migration, and induction of apoptosis via downregulating the acyl-CoA synthetase long chain family member 1 (ACSL1) and the brain-derived neurotrophic factor (BDNF). 21,22 In addition, bioinformatics analysis showed SNHG7 was associated with the processes of "protein translation", "viral life cycle", "RNA processing", "mRNA splicing", "histone ubiquitination", "endoplasmic reticulum-to-Golgi vesicle-mediated transport", "sister chromatid cohesion", "DNA damage checkpoint regulation", "translation", and "the spliceosome", suggesting further research directions for this lncRNA.…”

Section: Thyroid Cancermentioning

confidence: 99%

“…21,22 In addition, bioinformatics analysis showed SNHG7 was associated with the processes of "protein translation", "viral life cycle", "RNA processing", "mRNA splicing", "histone ubiquitination", "endoplasmic reticulum-to-Golgi vesicle-mediated transport", "sister chromatid cohesion", "DNA damage checkpoint regulation", "translation", and "the spliceosome", suggesting further research directions for this lncRNA. 20 SNHG12 is also upregulated (by 3.8-fold) in papillary thyroid carcinoma (PTC) tissues compared to normal adjacent tissue samples. 23 High SNHG12 was associated with poorer progression in PTC in terms of tumor node metastasis (TNM) staging and lymph node metastasis (LNM).…”

Section: Thyroid Cancermentioning

confidence: 99%

<p>Long Non-Coding Small Nucleolar RNA Host Genes (SNHGs) in Endocrine-Related Cancers</p>

Qin¹,

Sun²,

Wang³

et al. 2020

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Long non-coding RNAs (lncRNAs) are emerging regulators of a diverse range of biological processes through various mechanisms. Genome-wide association studies of tumor samples have identified several lncRNAs, which act as either oncogenes or tumor suppressors in various types of cancers. Small nucleolar RNAs (snoRNAs) are predominantly found in the nucleolus and function as guide RNAs for the processing of transcription. As the host genes of snoRNAs, lncRNA small nucleolar RNA host genes (SNHGs) have been shown to be abnormally expressed in multiple cancers and can participate in cell proliferation, tumor progression, metastasis, and chemoresistance. Here, we review the biological functions and emerging mechanisms of SNHGs involved in the development and progression of endocrine-related cancers including thyroid cancer, breast cancer, pancreatic cancer, ovarian cancer and prostate cancer.

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Long non‑coding RNA small nucleolar RNA host gene 7 is upregulated and promotes cell proliferation in thyroid cancer

Cited by 5 publications

References 44 publications

LncRNA SNHG7/miR-34a-5p/SYVN1 axis plays a vital role in proliferation, apoptosis and autophagy in osteoarthritis

LncRNA SNHG7/miR-34a-5p/SYVN1 axis plays a vital role in proliferation, apoptosis and autophagy in osteoarthritis

Molecular mechanisms of long non-coding RNAs in anaplastic thyroid cancer: a systematic review

<p>Long Non-Coding Small Nucleolar RNA Host Genes (SNHGs) in Endocrine-Related Cancers</p>

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