Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in Malignancy

Shen, Shen; Wang, Yanfang; Zhang, Yize; Dong, Zihui; Xing, Jiyuan

doi:10.3389/fcell.2021.746714

Cited by 13 publications

(7 citation statements)

References 92 publications

(132 reference statements)

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“…This is the first study analyzing the relationship between the expression level of SNHG14 and the prognosis and clinical characteristics among cancer patients. Shen et al (2021) previously described the expression profile, biological function, and molecular mechanism of SNHG14 in cancer, facilitating a molecular basis for future clinical application of SNHG14. We conducted a meta-analysis to evaluate the association between SNHG14 expression, OS, and the clinicopathological significance of different cancer types.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of LncRNA SNHG14 as a biomarker of clinicopathological and prognosis value in human cancers: A meta-analysis and bioinformatics analysis

Liu

Wang

et al. 2022

Front. Genet.

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Background: SNGH14 is a newly discovered long non-coding RNA (lncRNA) highly associated with tumorigenesis. However, whether the level of SNHG14 is related to the prognosis of patients with different cancer types is unclear.Methods: PubMed, Web of Science, Cochrane Library, and Embase were searched to identify eligible studies from inception to November 2021. The odds ratio (OR) and 95% confidence interval (CI) were utilized to analyze dichotomous variables, while the hazard ratio (HR) and 95% CI were used for survival outcomes. We also included trial sequential analysis (TSA) to assess whether the current evidence was sufficiently conclusive. Stata 15.0 and TSA 0.9 software were used for data analyses.Results: A total of 21 studies involving 1,080 patients, mainly from China, were included. Our results revealed that high SNHG14 expression was associated significantly with poor overall survival (OS) [HR = 1.39; 95% CI: (1.06–1.83); p = 0.017]. In addition, elevated SNHG14 expression was related to tumor size (> 3.5 cm) [OR = 1.60; 95% CI: (1.20–2.14); p = 0.001], TNM staging [OR = 0.54; 95% CI: (0.40–0.71); p < 0.001], lymph node metastasis [OR = 1.86; 95% CI: (1.35–2.55); p < 0.001], differentiation grade [OR = 1.95; 95% CI: (1.36–2.80); p < 0.001], and distant metastasis [OR = 2.44; 95% CI: (1.30–4.58); p = 0.005]. However, no significant difference was observed between age [OR = 0.98; 95% CI: (0.72–1.35); p = 0.915] and gender [OR = 0.98; 95% CI: (0.72–1.35); p = 0.915] from the enhanced expression of SNHG14.Conclusion: The current study revealed that overexpression of SNGH14 is associated with low OS rate and clinicopathological characteristics. SNGH14 can be a novel tumor marker that aids in tumor diagnosis, thereby improving patient prognosis.

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Section: Discussionmentioning

confidence: 99%

Overexpression of LncRNA SNHG14 as a biomarker of clinicopathological and prognosis value in human cancers: A meta-analysis and bioinformatics analysis

Liu

Wang

et al. 2022

Front. Genet.

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“…SNHG14 RNA is overexpressed in multiple cancer types, including non-small cell lung cancer, hepatocellular carcinoma, glioma, breast cancer, ovarian cancer, and colorectal cancer, among others [34]. These tissues generally have little to no expression of this lncRNA in their normal state.…”

Section: Expression Of Snhg14 Rnamentioning

confidence: 99%

Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader–Willi Syndrome Etiology

Ariyanfar

Good

2022

Genes

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The Small Nucleolar Host Gene 14 (SNHG14) is a host gene for small non-coding RNAs, including the SNORD116 small nucleolar C/D box RNA encoding locus. Large deletions of the SNHG14 locus, as well as microdeletions of the SNORD116 locus, lead to the neurodevelopmental genetic disorder Prader–Willi syndrome. This review will focus on the SNHG14 gene, its expression patterns, its role in human cancer, and the possibility that single nucleotide variants within the locus contribute to human phenotypes in the general population. This review will also include new in silico data analyses of the SNHG14 locus and new in situ RNA expression patterns of the Snhg14 RNA in mouse midbrain and hindbrain regions.

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“…11 The lncRNA SNHG14, also known as UBE3A-ATS, located on human chromosome 15q11.2, has been widely studied as an oncogene. 12 Knockout of lncRNA SNHG14 can significantly inhibit the survival and migration of gastric cancer SGC-7901 cells, and promote cell apoptosis. 13 Zhu et al claimed that silencing lncRNA SNHG14 could restrain lipopolysaccharidestimulated cell apoptosis and inflammatory response in an acute lung injury cell model.…”

Section: Introductionmentioning

confidence: 99%

“…Hu et al reported that lncRNA ANRIL up‐regulated the expression of BRCC protein by targeting miR‐122‐5p, and so activating NLRP3 inflammatory bodies and accelerating the development of uric acid‐induced inflammation, and promoting the occurrence and development of gouty nephropathy 11 . The lncRNA SNHG14, also known as UBE3A‐ATS, located on human chromosome 15q11.2, has been widely studied as an oncogene 12 . Knockout of lncRNA SNHG14 can significantly inhibit the survival and migration of gastric cancer SGC‐7901 cells, and promote cell apoptosis 13 .…”

Section: Introductionmentioning

confidence: 99%

Highly expressed long non‐coding RNA SNHG14 activated MSU‐induced inflammatory response in acute gout arthritis through targeting miR‐223‐3p

Yang,

Liu,

Yan

et al. 2023

Int J of Rheum Dis

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AimAccording to reports, long non‐coding RNAs (lncRNAs) are involved in the regulation of many inflammatory diseases. Here, our main purpose was to ascertain the expression data of lncRNA SNHG14 in acute gouty arthritis (AGA) and to explore its possible mechanism in the regulation of AGA.MethodReverse transcription quantitative polymerase chain reaction technology was supplied to detect the lncRNA SNHG14 expression. A receiver operating characteristics curve was drawn to estimate the accuracy of lncRNA SNHG14 in AGA diagnosis. An in vitro AGA cell model was constructed by inducing THP‐1 cells with monosodium urate (MSU). The concentrations of inflammatory factors such as interleukin‐1β, interleukin‐6, and tumor necrosis factor‐α were measured by enzyme‐linked immunosorbent assay. The luciferase reporter gene was used to verify the relationship between lncRNA SNHG14 and miR‐223‐3p.ResultsIn clinical analysis, the levels of serum lncRNA SNHG14 in AGA patients were significantly higher than those in the control group. Abnormally elevated lncRNA SNHG14 has high sensitivity and specificity for AGA diagnosis. In in vitro cell experiments, silencing lncRNA SNHG14 inhibited the inflammatory response of THP‐1 cells stimulated by MSU, and the luciferase reporter gene proved that lncRNA SNHG14 could bind to miR‐223‐3p. In addition, the level of miR‐223‐3p declined in AGA patients and the AGA cell model. Overexpression of miR‐223‐3p is helpful to alleviate an MSU‐induced inflammatory response.ConclusionIn the AGA cell model, lncRNA SNHG14, as an miR‐223‐3p sponge, induces a cellular inflammatory response by controlling the level of miR‐223‐3p, so aggravating the disease progress of AGA.

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Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in Malignancy

Cited by 13 publications

References 92 publications

Overexpression of LncRNA SNHG14 as a biomarker of clinicopathological and prognosis value in human cancers: A meta-analysis and bioinformatics analysis

Overexpression of LncRNA SNHG14 as a biomarker of clinicopathological and prognosis value in human cancers: A meta-analysis and bioinformatics analysis

Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader–Willi Syndrome Etiology

Highly expressed long non‐coding RNA SNHG14 activated MSU‐induced inflammatory response in acute gout arthritis through targeting miR‐223‐3p

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