Long non-coding RNA SNHG14 promotes microglia activation by regulating miR-145-5p/PLA2G4A in cerebral infarction

Xu, Qi; Shao, Ming; Sun, Hong-Jing; Shen, Yue; Meng, Delong; Huo, Wei

doi:10.1016/j.neuroscience.2017.02.002

Cited by 118 publications

(110 citation statements)

References 23 publications

Supporting

Mentioning

103

Contrasting

Order By: Relevance

“…These findings are interesting and merit further discussion. Consistent with the previous findings that lncRNA SNHG14 can enhance microglia activation in cerebral infarction via regulating miR-145-5p, 21 we also detected that miR-145 could be negatively regulated by lncRNA SNHG14 in this study. In previous studies, miR-145 is found down-regulated in gastric cancer tissues and cells and exerts tumor-suppressive role in gastric cancer.…”

Section: Discussionsupporting

confidence: 93%

“…It is reported that lncRNA SNHG14 can contribute to the activation of microglia cells via regulating miR-145-5p in cerebral infarction. 21 Therefore, we also investigated the regulatory relationship between SNHG14 and miR-145. As shown in Figure 3A, the expression of miR-145 in sh-SNHG14 group was significantly higher than that in sh-NC group (P < 0.001), indicating that miR-145 was negatively regulated by SNHG14.…”

Section: Snhg14 Mediated Tumor Malignant Behaviors Through Regulatimentioning

confidence: 99%

See 1 more Smart Citation

Retracted: Long non‐coding RNA SNHG14 contributes to gastric cancer development through targeting miR‐145/SOX9 axis

Liu

Yan

Cao

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

This study aimed to elucidate the roles of long non-coding RNA SNHG14 in gastric cancer development. LncRNA SNHG14 was markedly up-regulated in gastric cancer tissues and cells. Knockdown of SNHG14 significantly inhibited SGC-7901 cell viability, migration, invasion, and promoted cell apoptosis. In addition, miR-145 was negatively regulated by SNHG14 and the effects of SNHG14 knockdown on cell viability, apoptosis, migration, invasion, and the expression of apoptosis-related proteins and EMT-markers were reversed by inhibition of miR-145 at the same time. Furthermore, SOX9 was verified as a functional target of miR-145, and miR-145 regulated tumor malignant behaviors through regulating SOX9. Besides, knockdown of SNHG14 inhibited the expression of p-PI3 K, p-AKT, and p-mTOR and promoted PTEN expression, where miR-145 inhibition had opposite effects. Moreover, the activated PI3 K/AKT/mTOR pathway caused by miR-145 inhibition was counteracted after knockdown of SOX9. Our findings indicate that up-regulation of lncRNA SNHG14 may contribute to gastric cancer development via targeting miR-145/SOX9 axis and involving in PI3 K/AKT/mTOR pathway. SNHG14-miR-145/SOX9 axis may be a promising therapeutic strategy for gastric cancer treatment.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Snhg14 Mediated Tumor Malignant Behaviors Through Regulatimentioning

confidence: 99%

Retracted: Long non‐coding RNA SNHG14 contributes to gastric cancer development through targeting miR‐145/SOX9 axis

Liu

Yan

Cao

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

show abstract

“…Likewise, lncRNA Gm4419 could activate NF‐κB pathway and contributes to cell damage in oxygen‐glucose–deprived cerebral microglial cells . Another in vitro and in vivo study discloses that lncRNA SNHG14 elevates the expression of pro‐inflammatory factors (such as TNF‐α and nitric oxide), thereby aggravating neuron damage by regulating miR‐145‐5p/PLA2G4A . Therefore, these previous findings suggest that lncRNAs might be regulators in inflammation or biomarkers for disease progression in AIS.…”

Section: Discussionmentioning

confidence: 97%

The correlation of long non‐coding RNA intersectin 1‐2 with disease risk, disease severity, inflammation, and prognosis of acute ischemic stroke

Zhang

Niu

2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background This study aimed to evaluate the predictive value of long non‐coding RNA intersectin 1‐2 (lnc‐ITSN1‐2) for acute ischemic stroke (AIS) risk, and investigate its correlation with disease severity, inflammation, and recurrence‐free survival (RFS) in AIS patients. Methods Three hundred and twenty AIS patients were recruited, and plasma samples were collected within 24 hours after admission. lnc‐ITSN1‐2 expression form plasma was detected by reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR). The National Institute of Health Stroke Scale (NIHSS) score was assessed, and RFS was calculated. Meanwhile, 320 controls were enrolled and plasma samples were collected on the enrollment, and lnc‐ITSN1‐2 expression was detected by RT‐qPCR. Results lnc‐ITSN1‐2 expression was increased in AIS patients compared to controls (P < .001), and receiver operating characteristic curve revealed its predictive value for AIS risk (area under the curve: 0.804, 95% confidence interval, 0.763‐0.845). In AIS patients, lnc‐ITSN1‐2 expression was positively correlated with NIHSS score (r = 0.464, P < .001). For inflammation, lnc‐ITSN1‐2 expression was positively correlated with CRP (r = 0.398, P < .001), TNF‐α (r = 0.502, P < .001), IL‐1β (r = 0.313, P < .001), IL‐6 (r = 0.207, P < .001), IL‐8 (r = 0.400, P < .001), IL‐17 (r = 0.272, P < .001), and IL‐22 (r = 0.222, P < .001). In terms of predicted target microRNAs, lnc‐ITSN1‐2 expression was negatively correlated with microRNA (miR)‐107 (r = −0.467, P < .001), miR‐125a (r = −0.494, P < .001), and miR‐146a (r = −0.126, P = .025). For prognosis, high lnc‐ITSN1‐2 expression was correlated with worse RFS in AIS patients. Conclusion lnc‐ITSN1‐2 exerts a good predictive value for AIS risk; meanwhile, its increased expression is correlated with enhanced disease severity, elevated inflammation, and worse RFS in AIS patients.

show abstract

“…SNHG14, alternatively named UBE3A‐ATS, is located on chromosome 15q11.2. SNHG14 can overlap with the entire UBE3A gene and promoter, thus inhibited the expression of UBE3A, causing neurogenetic disorders, such as Angelman syndrome 15. Recently, Liu et al16 demonstrated that SNHG14 could act as a ceRNA to promote initiation and progression of clear cell renal cell carcinoma by regulating N‐WASP protein.…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding RNA SNHG14 induces trastuzumab resistance of breast cancer via regulating PABPC1 expression through H3K27 acetylation

Huang

Wang

et al. 2018

J Cellular Molecular Medi

101

View full text Add to dashboard Cite

Currently, resistance to trastuzumab, a human epidermal growth factor receptor 2 (HER2) inhibitor, has become one major obstacle for improving the clinical outcome of patients with advanced HER2+ breast cancer. While cell behaviour can be modulated by long non‐coding RNAs (lncRNAs), the contributions of lncRNAs in progression and trastuzumab resistance of breast cancer are largely unknown. To this end, the involvement and regulatory functions of lncRNA SNHG14 in human breast cancer were investigated. RT‐qPCR assay showed that SNHG14 was up‐regulated in breast cancer tissues and associated with trastuzumab response. Gain‐ and loss‐of‐function experiments revealed that overexpression of SNHG14 promotes cell proliferation, invasion and trastuzumab resistance, whereas knockdown of SNHG14 showed an opposite effect. PABPC1 gene was identified as a downstream target of SNHG14, and PABPC1 mediates the SNHG14‐induced oncogenic effects. More importantly, ChIP assays demonstrated that lncRNA SNHG14 may induce PABPC1 expression through modulating H3K27 acetylation in the promoter of PABPC1 gene, thus resulting in the activation of Nrf2 signalling pathway. These data suggest that lncRNA SNHG14 promotes breast cancer tumorigenesis and trastuzumab resistance through regulating PABPC1 expression through H3K27 acetylation. Therefore, SNHG14 may serve as a novel diagnostic and therapeutic target for breast cancer patients.

show abstract

Long non-coding RNA SNHG14 promotes microglia activation by regulating miR-145-5p/PLA2G4A in cerebral infarction

Cited by 118 publications

References 23 publications

Retracted: Long non‐coding RNA SNHG14 contributes to gastric cancer development through targeting miR‐145/SOX9 axis

Retracted: Long non‐coding RNA SNHG14 contributes to gastric cancer development through targeting miR‐145/SOX9 axis

The correlation of long non‐coding RNA intersectin 1‐2 with disease risk, disease severity, inflammation, and prognosis of acute ischemic stroke

Long non‐coding RNA SNHG14 induces trastuzumab resistance of breast cancer via regulating PABPC1 expression through H3K27 acetylation

Contact Info

Product

Resources

About