Long non-coding RNA SNHG5 suppresses gastric cancer progression by trapping MTA2 in the cytosol

Abstract

Recently, intriguing new roles for some small nucleolar RNA host genes (SNHGs) in cancer have emerged. In the present study, a panel of SNHGs was profiled to detect aberrantly expressed SNHGs in gastric cancer (GC). The expression of SNHG5 was significantly downregulated in GC and was significantly associated with the formation of a tumor embolus and with the tumor, node and metastasis stage. SNHG5 was a long non-coding RNA, which was a class of non-coding RNA transcripts longer than 200 nucleotides. SNHG5 suppressed GC cell proliferation and metastasis in vitro and in vivo. Furthermore, SNHG5 exerted its function through interacting with MTA2, preventing the translocation of MTA2 from the cytoplasm into the nucleus. SNHG5 overexpression led to significant increases in the acetylation levels of histone H3 and p53, indicating that SNHG5 might affect acetylation by trapping MTA2 in the cytosol, thereby interfering with the formation of the nucleosome remodeling and histone deacetylation complex. This study is the first to demonstrate that SNHG5 is a critical and powerful regulator that is involved in GC progression through trapping MTA2 in the cytosol. These results imply that SNHG5 may be a novel therapeutic target for the treatment of GC.

lncRNA SNHG5 is associated with poor prognosis of bladder cancer and promotes bladder cancer cell proliferation through targeting p27

“…Cui et al uncovered that upregulated lncRNA SNHG1 contributed to progression of non-small cell lung cancer through inhibition of miR-101-3p and activation of Wnt/β-catenin signaling pathway (25). SNHG5 is anomalously expressed in human gastric cancer and colorectal cancer (16,17). However, its biological function in BC has not been investigated.…”

“…Zhao et al demonstrated that overexpressed SNHG5 significantly represses the progression of gastric cancer (17,26). While, Damas et al uncovered that high level of SNHG5 obviously promotes cell survival in colorectal cancer (16).…”

“…These results suggested that SNHG5 expression might be associated with the level of malignancy of BC, and might be involved in the tumorigenesis and progression of BC. It has been demonstrated that the effect of SNHG5 is related with its biological function on cell proliferation (16,17). Therefore, we explored the biological function of SNHG5 in BC cells.…”

“…Small nucleolar RNA host gene 5 (SNHG5), a SnoRNA-U50-associated lncRNA, has been demonstrated downregulated in bladder cancer (BC) and colorectal carcinoma (CRC) (16,17). However, its biological function in BC has not been investigated.…”

lncRNA SNHG8 Promotes the Tumorigenesis and Metastasis by Sponging miR-149-5p and Predicts Tumor Recurrence in Hepatocellular Carcinoma

“…However, SNHG5 suppresses GC progression by trapping MTA2 in the cytosol [18], suggesting that SNHGs may also represent novel therapeutic targets for cancer.…”