Long non-coding RNA SNHG5 suppresses the development of acute respiratory distress syndrome by targeting miR-205/COMMD1 axis

Wang, Jiao; Zhang, Yang; Zhang, Lihai

doi:10.1007/s11010-020-03972-8

Cited by 7 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we first demonstrated that circARF3 can sponge miR-205-5p in AR. Numerous studies have found that miR-205-5p has a role in the inflammatory response in some diseases, such as cerebral ischemic/reperfusion injury, acute respiratory distress syndrome, and rheumatoid arthritis [42][43][44]. More importantly, increased miR-205-5p was found in the nasal mucosa of patients with AR [45].…”

Section: Discussionmentioning

confidence: 99%

CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis

Zheng

Chen

Zhan

et al. 2023

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Introduction: Circular RNAs (circRNAs) are essential in the progression of allergic rhinitis (AR). The purpose of this research was to examine the role of circRNA ADP-ribosylation factor 3 (circARF3) in the pathogenesis of AR. Methods: To generate an animal model of AR, mice were treated with house dust mite (HDM), and mice nasal epithelial cells (NEpCs) were treated with IL-4/IL-13 to imitate the inflammatory damage of AR in vitro. Sanger sequencing, qRT-PCR, and RNAse R digestion assays all validated the circularization structure of circARF3. The levels of circARF3, miR-205-5p, and sirtuin 5 (SIRT5) were determined by qRT-PCR or Western blotting. Luciferase reporter, RNA immunoprecipitation, and pull-down experiments were used to investigate the regulatory network. Flow cytometry was used to investigate the rate of cell apoptosis, and Western blotting was used to determine the levels of apoptotic-related proteins (cleaved caspase 3, cleaved polyadenosine-diphosphate-ribose polymerase) and HMGB1, TLR4, and MyD88. Enzyme-linked immunosorbent assay was used to assess the inflammatory response. Hematoxylin-eosin staining and TUNEL were used to detect the histology of injury and apoptosis of nasal mucosa tissues. Results: CircARF3 and SIRT5 levels were reduced in HDM-treated animals and IL-4/IL-13-treated NEpCs, while miR-205-5p expression was increased. CircARF3 was generated by back-splicing exons 3–5 with a stable circular shape. CircARF3 overexpression mitigated IL-4/IL-13-induced apoptosis in NEpCs by inhibiting miR-205-5p. SIRT5 upregulation attenuated IL-4/IL-13-induced inflammatory injury in NEpCs, and SIRT5 knockdown induced opposite effects. miR-205-5p silencing reversed the effects of SIRT5 knockdown on IL-4/IL-13-induced inflammatory injury. Furthermore, circARF3 overexpression alleviated histological abnormalities, apoptosis, inflammatory response, and HMGB1/TLR4 signaling activation in HDM-treated animals. Conclusion: CircARF3 inhibited cell apoptosis and inflammation via the miR-205-5p/SIRT5 axis in IL-4/IL-13-treated NEpCs and HDM-treated mice.

show abstract

Section: Discussionmentioning

confidence: 99%

CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis

Zheng

Chen

Zhan

et al. 2023

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…In 2021, W ang et al . [ 69 ] evaluated the serum levels of SNHG5 in 20 ARDS subjects and 20 controls with normal physiological indicators and no history of underlying disease. The relative expression of SNHG5 was downregulated in the serum of ARDS patients compared to controls.…”

Section: Circulating Lncrnas As Potential Tools In the Clinical Manag...mentioning

confidence: 99%

Exploring the translational landscape of the long noncoding RNA transcriptome in acute respiratory distress syndrome: it is a long way to the top

Belmonte,

Rodríguez-Muñoz,

Ferruelo

et al. 2024

Eur Respir Rev

View full text Add to dashboard Cite

Acute respiratory distress syndrome (ARDS) poses a significant and widespread public health challenge. Extensive research conducted in recent decades has considerably improved our understanding of the disease pathophysiology. Nevertheless, ARDS continues to rank among the leading causes of mortality in intensive care units and its management remains a formidable task, primarily due to its remarkable heterogeneity. As a consequence, the syndrome is underdiagnosed, prognostication has important gaps and selection of the appropriate therapeutic approach is laborious. In recent years, the noncoding transcriptome has emerged as a new area of attention for researchers interested in biomarker development. Numerous studies have confirmed the potential of long noncoding RNAs (lncRNAs), transcripts with little or no coding information, as noninvasive tools for diagnosis, prognosis and prediction of the therapeutic response across a broad spectrum of ailments, including respiratory conditions. This article aims to provide a comprehensive overview of lncRNAs with specific emphasis on their role as biomarkers. We review current knowledge on the circulating lncRNAs as potential markers that can be used to enhance decision making in ARDS management. Additionally, we address the primary limitations and outline the steps that will be essential for integration of the use of lncRNAs in clinical laboratories. Our ultimate objective is to provide a framework for the implementation of lncRNAs in the management of ARDS.

show abstract

“…For example, Lnc-MALAT1 could sponge miR-149 ( Liang et al., 2019 ), miR-146a ( Dai et al., 2018 ) and miR-425 ( Wang et al., 2019 ) and Lnc-PRNCR1 could sponge miR-330-5p ( Yu et al., 2021 ). Lnc-SNHG5 could sponge miR-205 ( Wang J. et al., 2021 ) in LPS-induced ARDS model and Lnc-XIST can sponge miR-146a-5p ( Li J. et al., 2021 ). Lnc-TUG1 transmitted by EPC-derived EVs could bind to miR-9-5p, promote M2 macrophage polarization and ameliorate sepsis-induced organ damage ( Ma et al., 2021 ).…”

Section: The Role Of Ev Contents In Sepsis and Ardsmentioning

confidence: 99%

Extracellular Vesicles, New Players in Sepsis and Acute Respiratory Distress Syndrome

Jing

Wang

Zhan

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Sepsis refers to a complex syndrome associated with physiological, pathological, and biochemical abnormalities resulted from infection. Sepsis is the major cause of acute respiratory distress syndrome (ARDS). Extracellular vesicles (EVs) are serving as new messengers to mediate cell-cell communication in vivo. Non-coding RNAs, proteins and metabolites encapsulated by EVs could result in either pro-inflammatory or anti-inflammatory effects in the recipient cells. Pathogens or host cells derived EVs play an important role in pathogens infection during the occurrence and development of sepsis and ARDS. Additionally, we summarize the potential application for EVs in diagnosis, prevention and treatment for sepsis and ARDS.

show abstract

Long non-coding RNA SNHG5 suppresses the development of acute respiratory distress syndrome by targeting miR-205/COMMD1 axis

Cited by 7 publications

References 39 publications

CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis

CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis

Exploring the translational landscape of the long noncoding RNA transcriptome in acute respiratory distress syndrome: it is a long way to the top

Extracellular Vesicles, New Players in Sepsis and Acute Respiratory Distress Syndrome

Contact Info

Product

Resources

About