Long non-coding RNA SOX21-AS1 modulates breast cancer stem cells properties and carcinogenesis via targeting SOX2

Lu, Zhen-Duo; Jiao, Dechao; Qiao, Jie; Yang, Sen; Liu, Zhenzhen

doi:10.18632/oncotarget.23593

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…Remarkably, SOX21-AS1 knockdown was shown to reduce proliferation, invasion, tumor growth, stem factor expression of the CD44 + /CD24 − population in vitro and in vivo. This investigation suggests that SOX21-AS1 controls bCSC properties and carcinogenesis via targeting Sox2 [ 148 ]. Posteriorly, it was corroborated that the lncRNA SOX21-AS1 is highly expressed in bCSCs of MCF-7 and MDA-MB-231, promoting bCSC properties as well as the proliferation, migration, and invasion abilities of CSC-MCF-7 cells through inhibiting the Hippo signaling pathway [ 149 ].…”

Section: The Lncrna: Key Molecules In the Breast Cancer Stem Cellsmentioning

confidence: 99%

LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells

et al. 2021

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Breast cancer is an aggressive disease with a high incidence in women worldwide. Two decades ago, a controversial hypothesis was proposed that cancer arises from a subpopulation of “tumor initiating cells” or “cancer stem cells-like” (CSC). Today, CSC are defined as small subset of somatic cancer cells within a tumor with self-renewal properties driven by the aberrant expression of genes involved in the maintenance of a stemness-like phenotype. The understanding of the underlying cellular and molecular mechanisms involved in the maintenance of CSC subpopulation are fundamental in the development and persistence of breast cancer. Nowadays, the hypothesis suggests that genetic and epigenetic alterations give rise to breast cancer stem cells (bCSC), which are responsible for self-renewal, tumor growth, chemoresistance, poor prognosis and low survival in patients. However, the prominence of bCSC, as well as the molecular mechanisms that regulates and promotes the malignant phenotypes, are still poorly understood. The role of non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) acting as oncogenes or tumor suppressor genes has been recently highlighted by a plethora of studies in breast cancer. These ncRNAs positively or negatively impact on different signaling pathways that govern the cancer hallmarks associated with bCSC, making them attractive targets for therapy. In this review, we present a current summary of the studies on the pivotal roles of lncRNAs and microRNAs in the regulation of genes associated to stemness of bCSC.

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Section: The Lncrna: Key Molecules In the Breast Cancer Stem Cellsmentioning

confidence: 99%

LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells

et al. 2021

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“…Notably, SOX21-AS1 knockdown was proven to diminish proliferation, invasion and stem factor, i.e., Nanog, LIN28, Oct4 and SOX2, of BCSCs. This study indicates that SOX21-AS1 regulates properties and carcinogenesis of BCSC via targeting SOX2 [ 117 ]. It was further confirmed that the lncRNA SOX21-AS1 is overexpressed in BCSCs of MCF-7 and MDA-MB-231, enhancing stemness of BCSC as well as proliferation, invasion and migration in CSC-MCF-7 cells via suppressing the Hippo signaling pathway [ 118 ].…”

Section: Epigenetic Regulation In Breast Cancer and Bcscsmentioning

confidence: 99%

Epigenetic Regulation of Breast Cancer Stem Cells Contributing to Carcinogenesis and Therapeutic Implications

Chu

2021

IJMS

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Globally, breast cancer has remained the most commonly diagnosed cancer and the leading cause of cancer death among women. Breast cancer is a highly heterogeneous and phenotypically diverse group of diseases, which require different selection of treatments. Breast cancer stem cells (BCSCs), a small subset of cancer cells with stem cell-like properties, play essential roles in breast cancer progression, recurrence, metastasis, chemoresistance and treatments. Epigenetics is defined as inheritable changes in gene expression without alteration in DNA sequence. Epigenetic regulation includes DNA methylation and demethylation, as well as histone modifications. Aberrant epigenetic regulation results in carcinogenesis. In this review, the mechanism of epigenetic regulation involved in carcinogenesis, therapeutic resistance and metastasis of BCSCs will be discussed, and finally, the therapies targeting these biomarkers will be presented.

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“…Recent studies have shown that lncRNA SOX21-AS1 is located at chromosome 13q32.1 and transcribed into a 2986 nucleotide transcript, which exerts important functions in tumorigenesis and maintenance of tumor stem cell characteristics [9]. For example, SOX21-AS1 modulates breast cancer stem cells properties and carcinogenesis via targeting SOX2 [10]. Although there is evidence that SOX21-AS1 is involved in the proliferation, invasion and maintenance of the stemness of BCSCs [10][11][12], the underlying molecular mechanisms remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…For example, SOX21-AS1 modulates breast cancer stem cells properties and carcinogenesis via targeting SOX2 [10]. Although there is evidence that SOX21-AS1 is involved in the proliferation, invasion and maintenance of the stemness of BCSCs [10][11][12], the underlying molecular mechanisms remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding RNA SOX21‐AS1 enhances the stemness of breast cancer cells via the Hippo pathway

Meng

Wang

2020

FEBS Open Bio

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Breast cancer stem cells (BCSCs) have high tumorigenicity and invasiveness which contributes to recurrence and metastasis. The long non-coding RNA (LncRNA) SOX21-AS1 has been previously reported to modulate the properties of breast cancer stem cells via targeting SOX2, but the underlying molecular mechanisms are unclear. To investigate this issue, here we first confirmed that the expression level of SOX21-AS1 is increased in breast cancer tissues and cell lines (MCF-7, MDA-MB-231, CSC-MCF-7, CSC-MDA-MB-231), especially in BCSCs. We demonstrated that SOX21-AS1 promotes the stemness of CSC-MCF-7 cells through western blot detection of stemness-related proteins, and side population (SP) and sphere formation assays. Overexpression of SOX21-AS1 enhanced the proliferation, migration and invasion of CSC-MCF-7 cells. We also observed that SOX21-AS1 inhibited the Hippo pathway. SOX21-AS1 enhanced the stemness, migration, and invasion of CSC-MCF-7 cells by increasing the nuclear localization of YAP and decreasing the level of pYAP. Overall, we conclude that SOX21-AS1 may promote the stemness viability, proliferation, migration and invasion of BCSCs by inhibiting the Hippo pathway. Our findings provide insights into potential biomarkers and prognostic measures for the treatment of breast cancer.

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Long non-coding RNA SOX21-AS1 modulates breast cancer stem cells properties and carcinogenesis via targeting SOX2

Cited by 4 publications

References 33 publications

LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells

LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells

Epigenetic Regulation of Breast Cancer Stem Cells Contributing to Carcinogenesis and Therapeutic Implications

Long non‐coding RNA SOX21‐AS1 enhances the stemness of breast cancer cells via the Hippo pathway

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