Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis

Wang, Xinfang; Chen, Jun Song

doi:10.1186/s12860-021-00396-0

Cited by 6 publications

(3 citation statements)

References 37 publications

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“…In other words, the TUG1–miR-138-5p–E2F3 regulatory axis was critical to the acceleration of viability and migration of ASMCs [ 101 ]. Similarly, TUG1 level was also increased in asthmatic patients and PDGF-BB-stimulated human ASMCs; TUG1 promoted PDGF-BB-induced ASMC proliferation and migration via competitively adsorbing miR-216a-3p, directly targeting the miR-216a-3p-SMURF2 axis [ 102 ]. The above data offers novel insights into the role of TUG1 in asthmatic ASMCs and highlights its potential for use in treatment development.…”

Section: Lncrnas In Asthmatic Asmcsmentioning

confidence: 99%

Noncoding RNAs in asthmatic airway smooth muscle cells

Xiao

Dong

et al. 2023

Eur Respir Rev

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Asthma is a complex and heterogeneous airway disease caused by genetic, environmental and epigenetic factors treated with hormones and biologics. Irreversible pathological changes to airway smooth muscle cells (ASMCs) such as hyperplasia and hypertrophy can occur in asthmatic patients. Determining the mechanisms responsible is vital for preventing such changes. In recent years, noncoding RNAs (ncRNAs), especially microRNAs, long noncoding RNAs and circular RNAs, have been found to be associated with abnormalities of the ASMCs. This review highlights recent ncRNA research into ASMC pathologies. We present a schematic that illustrates the role of ncRNAs in pathophysiological changes to ASMCs that may be useful in future research in diagnostic and treatment strategies for patients with asthma.

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Section: Lncrnas In Asthmatic Asmcsmentioning

confidence: 99%

Noncoding RNAs in asthmatic airway smooth muscle cells

Xiao

Dong

et al. 2023

Eur Respir Rev

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“…However, by sponging, TUG1 inhibits this function and activates the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling pathway and promotes airway remodelling 58. Two recent studies confirmed the involvement of TUG1 in ASMC proliferation in human asthma, by impacting on the miR216a-SMURF2 axis and the miR-138–E2F3 axis 59 60…”

Section: Functional Role Of Lncrnas In Asthmamentioning

confidence: 99%

Unlocking the secrets of long non-coding RNAs in asthma

Gysens

Mestdagh

Lavergne

et al. 2022

Thorax

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Asthma is a very heterozygous disease, divided in subtypes, such as eosinophilic and neutrophilic asthma. Phenotyping and endotyping of patients, especially patients with severe asthma who are refractory to standard treatment, are crucial in asthma management and are based on a combination of clinical and biological features. Nevertheless, the quest remains to find better biomarkers that distinguish asthma subtypes in a more clear and objective manner and to find new therapeutic targets to treat people with therapy-resistant asthma. In the past, research to identify asthma subtypes mainly focused on expression profiles of protein-coding genes. However, advances in RNA-sequencing technologies and the discovery of non-coding RNAs as important post-transcriptional regulators have provided an entire new field of research opportunities in asthma. This review focusses on long non-coding RNAs (lncRNAs) in asthma; these are non-coding RNAs with a length of more than 200 nucleotides. Many lncRNAs are differentially expressed in asthma, and several have been associated with asthma severity or inflammatory phenotype. Moreover, in vivo and in vitro functional studies have identified the mechanisms of action of specific lncRNAs. Although lncRNAs remain not widely studied in asthma, the current studies show the potential of lncRNAs as biomarkers and therapeutic targets as well as the need for further research.

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“…For example, lncRNA growth arrest-specific transcript 5 (GAS5), lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1), and lncRNA PVT1 can act as “sponges” of miR-10a, miR-9-5p, and miR-29c-3p, respectively, and are involved in the biological processes of ASMC proliferation, migration, apoptosis and inflammation in asthmatic patients ( Zhang et al, 2018b ; Wei et al, 2020 ; Wang et al, 2021d ). TUG1, serving as the molecular sponge of miR-138-5p, miR-590-5p, miR-216a-3p, and miR-181b, has been confirmed to be involved in ASMC proliferation and migration in human asthma by modulating E2F transcription factor 3 (E2F3), fibroblast growth factor 1 (FGF1), Smurf2 and HMGB1, respectively ( Lin et al, 2019a ; Huang et al, 2021 ; Wang and Chen, 2021 ; Zhou et al, 2021 ). Similarly, the lncRNA Malat1 also contains multiple binding sites to miRNAs and sponges miR-150 ( Lin et al, 2019b ) and miR-133a ( Yang and Wang, 2021 ) in addition to the aforementioned miR-155 ( Liang and Tang, 2020 ), thereby regulating PDGF-BB-stimulated ASMC proliferation and migration.…”

Section: Lncrna–mirna Interaction In Chronic Inflammatory Airway Dise...mentioning

confidence: 99%

The Novel Regulatory Role of the lncRNA–miRNA–mRNA Axis in Chronic Inflammatory Airway Diseases

Qiao

Hou

et al. 2022

Front. Mol. Biosci.

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Chronic inflammatory airway diseases, characterized by airway inflammation and airway remodelling, are increasing as a cause of morbidity and mortality for all age groups and races across the world. The underlying molecular mechanisms involved in chronic inflammatory airway diseases have not been fully explored. MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have recently attracted much attention for their roles in the regulation of a variety of biological processes. A number of studies have confirmed that both lncRNAs and miRNAs can regulate the initiation and progression of chronic airway diseases by targeting mRNAs and regulating different cellular processes, such as proliferation, apoptosis, inflammation, migration, and epithelial–mesenchymal transition (EMT). Recently, accumulative evidence has shown that the novel regulatory mechanism underlying the interaction among lncRNAs, miRNAs and messenger RNAs (mRNAs) plays a critical role in the pathophysiological processes of chronic inflammatory airway diseases. In this review, we comprehensively summarized the regulatory roles of the lncRNA–miRNA–mRNA network in different cell types and their potential roles as biomarkers, indicators of comorbidities or therapeutic targets for chronic inflammatory airway diseases, particularly chronic obstructive pulmonary disease (COPD) and asthma.

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Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis

Cited by 6 publications

References 37 publications

Noncoding RNAs in asthmatic airway smooth muscle cells

Noncoding RNAs in asthmatic airway smooth muscle cells

Unlocking the secrets of long non-coding RNAs in asthma

The Novel Regulatory Role of the lncRNA–miRNA–mRNA Axis in Chronic Inflammatory Airway Diseases

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