Long non-coding RNA tumor protein 73 antisense RNA 1 influences an interaction between lysine demethylase 5A and promoter of tumor protein 73 to enhance the malignancy of colorectal cancer

Huang, Zhe; Wang, He; Yang, Mingli

doi:10.1007/s13577-022-00740-2

Cited by 1 publication

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent investigations have shown that hundreds of lncRNAs undergo significant changes during the aging process in many organisms, including rhesus monkeys [ 9 ] and C. elegans [ 10 ]. Additional investigations have confirmed that lncRNAs are involved in the pathogenesis of various age-related disorders, such as liver cancer [ 11 ], colorectal cancer [ 12 ], vascular aging [ 13 ], and Parkinson’s disease [ 14 ], implying that lncRNAs play a role in the growth and aging of various tissues and organs. Previous studies have shown that, at the epigenetic level, lncRNAs in the hippocampus are closely related to various age-related neuropsychiatric diseases [ 15 ], suggesting that lncRNAs in the hippocampus may play an important role in brain aging.…”

Section: Introductionmentioning

confidence: 99%

Identification of a hippocampal lncRNA-regulating network in a natural aging rat model

Liu

et al. 2022

BMC Neurosci

View full text Add to dashboard Cite

Background Dysregulation of long noncoding RNA (lncRNA) expression is related to aging and age-associated neurodegenerative diseases, and the lncRNA expression profile in the aging hippocampus is not well characterized. In the present investigation, the changed mRNAs and lncRNAs were confirmed via deep RNA sequencing. GO and KEGG pathway analyses were conducted to investigate the principal roles of the clearly dysregulated mRNAs and lncRNAs. Subsequently, through the prediction of miRNAs via which mRNAs and lncRNAs bind together, a competitive endogenous RNA network was constructed. Results A total of 447 lncRNAs and 182 mRNAs were upregulated, and 385 lncRNAs and 144 mRNAs were downregulated. Real-time reverse transcription-polymerase chain reaction validated the reliability of mRNA and lncRNA sequencing. KEGG pathway and GO analyses revealed that differentially expressed (DE) mRNAs were associated with cell adhesion molecules (CAMs), the p53 signaling pathway (SP), phagosomes, PPAR SP and ECM—receptor interactions. KEGG pathway and GO analyses showed that the target genes of the DE lncRNAs were related to cellular senescence, the p53 signaling pathway, leukocyte transendothelial migration and tyrosine metabolism. Coexpression analyses showed that 561 DE lncRNAs were associated with DE mRNAs. A total of 58 lncRNA–miRNA–mRNA target pairs were confirmed in this lncRNA‒miRNA‒mRNA network, comprising 10 mRNAs, 13 miRNAs and 38 lncRNAs. Conclusions We found specific lncRNAs and mRNAs in the hippocampus of natural aging model rats, as well as abnormal regulatory ceRNA networks. Our outcomes help explain the pathogenesis of brain aging and provide direction for further research.

show abstract

Section: Introductionmentioning

confidence: 99%

Identification of a hippocampal lncRNA-regulating network in a natural aging rat model

Liu

et al. 2022

BMC Neurosci

View full text Add to dashboard Cite

show abstract

Long non-coding RNA tumor protein 73 antisense RNA 1 influences an interaction between lysine demethylase 5A and promoter of tumor protein 73 to enhance the malignancy of colorectal cancer

Cited by 1 publication

References 30 publications

Identification of a hippocampal lncRNA-regulating network in a natural aging rat model

Identification of a hippocampal lncRNA-regulating network in a natural aging rat model

Contact Info

Product

Resources

About