Long Non-Coding RNA UCA1 Correlates With Electropathology in Patients With Atrial Fibrillation

Ramos, Kennedy Silva; Li, Jin; Wijdeveld, Leonoor F.J.; Schie, Mathijs S. van; Taverne, Yannick J.H.J.; Boon, Reinier A.; Groot, Natasja M.S. de; Brundel, Bianca J. J. M.

doi:10.2139/ssrn.4227625

Cited by 1 publication

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“…Prior mapping studies demonstrated that even during sinus rhythm, CB is more prevalent in patients with AF compared to patients without AF [9]. The increase in conduction disorders can be explained by a higher degree of structural remodeling consisting of, e.g., interstitial fibrosis and proteostasis derailment, which occurs not only at the endo-or epicardium but also transmurally [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Identification of Atrial Transmural Conduction Inhomogeneity Using Unipolar Electrogram Morphology

Zhang,

van Schie,

Xiang

et al. 2024

JCM

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(1) Background: Structural remodeling plays an important role in the pathophysiology of atrial fibrillation (AF). It is likely that structural remodeling occurs transmurally, giving rise to electrical endo-epicardial asynchrony (EEA). Recent studies have suggested that areas of EEA may be suitable targets for ablation therapy of AF. We hypothesized that the degree of EEA is more pronounced in areas of transmural conduction block (T-CB) than single-sided CB (SS-CB). This study examined the degree to which SS-CB and T-CB enhance EEA and which specific unipolar potential morphology parameters are predictive for SS-CB or T-CB. (2) Methods: Simultaneous endo-epicardial mapping in the human right atrium was performed in 86 patients. Potential morphology parameters included unipolar potential voltages, low-voltage areas, potential complexity (long double and fractionated potentials: LDPs and FPs), and the duration of fractionation. (3) Results: EEA was mostly affected by the presence of T-CB areas. Lower potential voltages and more LDPs and FPs were observed in T-CB areas compared to SS-CB areas. (4) Conclusion: Areas of T-CB could be most accurately predicted by combining epicardial unipolar potential morphology parameters, including voltages, fractionation, and fractionation duration (AUC = 0.91). If transmural areas of CB indeed play a pivotal role in the pathophysiology of AF, they could theoretically be used as target sites for ablation.

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