Long non‐coding RNA UCA1 correlates with elevated disease severity, Th17 cell proportion, inflammatory cytokines, and worse prognosis in acute ischemic stroke patients

Ren, Bin; Song, Zhen; Chen, Laizhao; Niu, Xiaomin; Feng, Qiang

doi:10.1002/jcla.23697

Cited by 23 publications

(18 citation statements)

References 16 publications

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“…Data suggested that MIAT might be a potential diagnostic and prognostic indicator in IS ( Zhu et al, 2018 ). LncRNA HULC is correlated with higher AIS risk, increased disease severity, and worse prognosis in AIS patients ( Ren et al, 2021 ). Meanwhile, it associates with higher IL-6, elevated intercellular adhesion molecule 1 (ICAM1), and lower miR-9 AIS patients ( Chen X. et al, 2020 ).…”

Section: Lncrnas As Potential Diagnostic and Prognostic Biomarkersmentioning

confidence: 99%

Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges

Zhang

Zhu

et al. 2021

Front. Pharmacol.

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Ischemic stroke (IS) is a disease that is characterized by high mortality and disability. Recent studies have shown that LncRNA-mediated competing endogenous RNA (ceRNA) networks play roles in the occurrence and development of cerebral I/R injury by regulating different signaling pathways. However, no systematic analysis of ceRNA mechanisms in IS has been reported. In this review, we discuss molecular mechanisms of LncRNA-mediated ceRNA networks under I/R injury. The expression levels of LncRNAs, microRNAs (miRNAs), and messenger RNAs (mRNAs) and their effects in four major cell types of the neurovascular unit (NVU) are also involved. We further summarize studies of LncRNAs as biomarkers and therapeutic targets. Finally, we analyze the advantages and limitations of using LncRNAs as therapeutics for IS.

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Section: Lncrnas As Potential Diagnostic and Prognostic Biomarkersmentioning

confidence: 99%

Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges

Zhang

Zhu

et al. 2021

Front. Pharmacol.

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“… 18 , 19 , 20 , 21 While few studies report the roles of lnc‐UCA1, miR‐26a, and miR‐195 in cardiovascular disease patients especially in CHD patients, not to mention the intercorrelation between lnc‐UCA1 and miR‐26a and miR‐195 in these patients. 22 , 23 In our preliminary study with a relatively small sample size, we observed an elevation of lnc‐UCA1 expression in CHD patients compared to controls.…”

Section: Introductionmentioning

confidence: 70%

“…Also, miR‐26a and miR‐195 are two well‐established microRNAs with protective roles in cardiovascular diseases by regulating proliferation, migration, and invasion of vasculature‐related cell (such as endothelial cell and VSMCs) 18–21 . While few studies report the roles of lnc‐UCA1, miR‐26a, and miR‐195 in cardiovascular disease patients especially in CHD patients, not to mention the intercorrelation between lnc‐UCA1 and miR‐26a and miR‐195 in these patients 22,23 . In our preliminary study with a relatively small sample size, we observed an elevation of lnc‐UCA1 expression in CHD patients compared to controls.…”

Section: Introductionmentioning

confidence: 75%

LncRNA UCA1, miR‐26a, and miR‐195 in coronary heart disease patients: Correlation with stenosis degree, cholesterol levels, inflammatory cytokines, and cell adhesion molecules

Chen

Wang

et al. 2021

Clinical Laboratory Analysis

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Background Long noncoding RNA urothelial cancer‐associated 1 (lnc‐UCA1) targets microRNA‐26a (miR‐26a) and microRNA‐195 (miR‐195) to participate in coronary heart disease (CHD) progression via regulation of vascular smooth muscle cell and microvascular endothelial cell viability and mobility. Therefore, this study set out to further explore the relationship between lnc‐UCA1 and miR‐26a and miR‐195, along with their roles in the management of patients with CHD. Methods One hundred and thirty‐six CHD patients and 70 age‐/gender‐matched controls were recruited in this case‐control study. Their peripheral blood mononuclear cell samples were collected for lnc‐UCA1, miR‐26a, and miR‐195 measurement. Furthermore, serum samples from CHD patients were obtained for inflammatory cytokines and cell adhesion molecules measurement. The Gensini score was used to evaluate the stenosis severity in CHD patients. Results Lnc‐UCA1 expression tend to be increased, while miR‐26a and miR‐195 expressions were reduced in patients with CHD compared to that of controls (all p < 0.001). In CHD patients, lnc‐UCA1 was negatively correlated with miR‐26a (p < 0.001) and miR‐195 (p = 0.014). Besides, lnc‐UCA1 was positively correlated with Gensini score (p < 0.001), total cholesterol (p = 0.019), low‐density lipoprotein cholesterol (p = 0.002), and C‐reactive protein (p < 0.001), while miR‐26a (p < 0.001) and miR‐195 (p = 0.002) were negatively correlated with Gensini score. What's more, lnc‐UCA1 was positively correlated with tumor necrosis factor (TNF)‐α (p = 0.004), interleukin (IL)‐1β (p = 0.041), vascular cell adhesion molecule‐1 (VCAM‐1) (p = 0.010), and intercellular adhesion molecule‐1 (ICAM‐1) (p < 0.001). While miR‐26a was negatively correlated with some of the individual inflammatory cytokines and cell adhesion molecules. Conclusion Lnc‐UCA1, miR‐26a, and miR‐195 may serve as potential biomarkers for CHD management.

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“…A rigorous search of publications on the expression of various lncRNAs in clinical studies published in three electronic databases, namely, PubMed, the Web of Science and EMBASE, until May 31, 2021, identified 6 studies that included 966 participants. [100][101][102][103][104][105] Several lncRNAs have been revealed as novel biomarkers that predict higher or lower stroke risk and contribute to the evaluation of disease severity, inflammation level, and prognosis in stroke participants. 136 Ren et al illustrated that lncRNA MALAT1 decreased and revealed a strong relationship with ischemic conditions, and a higher level was positively associated with a changed National Institutes of Health Stroke Scale (NIHSS) score and induced IL-10 in 200 ischemic stroke cases.…”

Section: Lncrna Regulation Correlates With the Level Of Inflammatory Cytokines In Stroke Patientsmentioning

confidence: 99%

Emerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation

Pan

Jiao

Wei

et al. 2021

JIR

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As a crucial kind of pervasive gene, long noncoding RNAs (lncRNAs) are abundant and key players in brain function as well as numerous neurological disorders, especially ischemic stroke. The mechanisms underlying ischemic stroke include angiogenesis, autophagy, apoptosis, cell death, and neuroinflammation. Inflammation plays a vital role in the pathological process of ischemic stroke, and systemic inflammation affects the patient's prognosis. Although a great deal of research has illustrated that various lncRNAs are closely relevant to regulate neuroinflammation and microglial activation in ischemic stroke, the specific interactional relationships and mechanisms between lncRNAs and neuroinflammation have not been described clearly. This review aimed to summarize the therapeutic effects and action mechanisms of lncRNAs on ischemia by regulating inflammation and microglial activation. In addition, we emphasize that lncRNAs have the potential to modulate inflammation by inhibiting and activating various signaling pathways, such as microRNAs, NF-κB and ERK.

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Long non‐coding RNA UCA1 correlates with elevated disease severity, Th17 cell proportion, inflammatory cytokines, and worse prognosis in acute ischemic stroke patients

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 23 publications

References 16 publications

Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges

Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges

LncRNA UCA1, miR‐26a, and miR‐195 in coronary heart disease patients: Correlation with stenosis degree, cholesterol levels, inflammatory cytokines, and cell adhesion molecules

Emerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation

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