Long non-coding RNA XIST: a novel oncogene in multiple cancers

Yang, Jun; Qi, Manlong; Fei, Xiang; Wang, Xia; Wang, Kefeng

doi:10.1186/s10020-021-00421-0

Cited by 40 publications

(29 citation statements)

References 123 publications

(145 reference statements)

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“…Interestingly, the role of XIST in PTC cell proliferation, migration, and invasion was also reported and ascribed to the ability of XIST to target miR-141 [85]. Through sponging miR-101 (as shown in ESCC), it is also likely that XIST overexpression may increase the levels of EZH2, a protein that plays a critical role in ATC [87] and whose overexpression in this malignancy is supported by epigenetic mechanisms involving miRNAs and lncRNAs, as previously reported [83,88].…”

Section: The Lncrna X Inactive Specific Transcript (Xist)mentioning

confidence: 68%

“…The lncRNA XIST is a key factor in the regulation of X chromosome inactivation in mammals. Its overexpression was recently reported in a large variety of human malignancies in comparison with adjacent normal tissues [83]. Therefore, XIST can be regarded as a novel oncogene that acts by interacting with different miRNAs.…”

Section: The Lncrna X Inactive Specific Transcript (Xist)mentioning

confidence: 93%

“…Therefore, XIST can be regarded as a novel oncogene that acts by interacting with different miRNAs. Indeed, XIST suppression decreases cell growth and invasion and induces apoptosis in non-small-cell lung carcinoma (NSCLC) through the inhibition of miR-186-5p [83], while it promotes the progression of human hepatocellular carcinoma through the repression of the PTEN suppressor gene. It is noteworthy that, in esophageal squamous cell carcinoma (ESCC), XIST leads to increased levels of the enhancer of zeste homolog 2 (EZH2) by sequestering miR-101 [83].…”

Section: The Lncrna X Inactive Specific Transcript (Xist)mentioning

confidence: 99%

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Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

Martino

Esposito

Capone

et al. 2022

Cancers

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Among the thyroid neoplasias originating from follicular cells, we can include well-differentiated carcinomas, papillary (PTC) and follicular (FTC) thyroid carcinomas, and the undifferentiated anaplastic (ATC) carcinomas. Several mutations in oncogenes and tumor suppressor genes have already been observed in these malignancies; however, we are still far from the comprehension of their full regulation-altered landscape. Even if only 2% of the human genome has the ability to code for proteins, most of the noncoding genome is transcribed, constituting the heterogeneous class of noncoding RNAs (ncRNAs), whose alterations are associated with the development of several human diseases, including cancer. Hence, many scientific efforts are currently focused on the elucidation of their biological role. In this review, we analyze the scientific literature regarding the involvement of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and pseudogenes in FTC, PTC, and ATC. Recent findings emphasized the role of lncRNAs in all steps of cancer progression. In particular, lncRNAs may control progression steps by regulating the expression of genes and miRNAs involved in cell proliferation, apoptosis, epithelial–mesenchymal transition, and metastatization. In conclusion, the determination of the diagnosis, prognosis, and treatment of cancer based on the evaluation of the ncRNA network could allow the implementation of a more personalized approach to fighting thyroid tumors.

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Section: The Lncrna X Inactive Specific Transcript (Xist)mentioning

confidence: 68%

Section: The Lncrna X Inactive Specific Transcript (Xist)mentioning

confidence: 93%

Section: The Lncrna X Inactive Specific Transcript (Xist)mentioning

confidence: 99%

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Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

Martino

Esposito

Capone

et al. 2022

Cancers

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“…Long non-coding RNA (LncRNA) is a transcript encoded by eukaryotic cell genome, with a length more than 200 nucleotides, which is crucial for cell proliferation, tumorigenesis and inflammatory response ( Yang et al, 2021 ). In most cases, the expression of lncRNAs is generally lower than that of protein encoded RNAs in human tissues.…”

Section: Introductionmentioning

confidence: 99%

The emerging role of long non-coding RNAs in renal cell carcinoma progression and clinical therapy via targeting metabolic regulation

Gao

Zhang

et al. 2023

Front. Pharmacol.

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“…Numerous lncRNAs are key molecules regulating the biological processes in cancer, such as the individual cell cycle as well as cell growth, proliferation, migration, invasion, and apoptosis (9)(10)(11). Some lncRNAs may potentially be utilized as diagnostic biomarkers and therapeutic bio-targets for HCC treatment (12), and are influential in colorectal cancer (13), pancreatic ductal adenocarcinoma (14), breast cancer (15), and the occurrence of prostate cancer (16).…”

Section: Introductionmentioning

confidence: 99%

A novel biomarker NIFK-AS1 promotes hepatocellular carcinoma cell cycle progression through interaction with SRSF10

Song¹,

Li²,

Guo³

et al. 2022

J Gastrointest Oncol

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Background: Hepatocellular carcinoma (HCC) is one of the most common carcinomas all over the world, with high mortality and low survival rate. Notably, many studies have showed that a variety of molecules play vital roles in the progression of HCC. Therefore, it is urgent to find reliable biomarkers to diagnose HCC and developing novel strategies are required for the effective treatment of patients with HCC.Methods: This study obtained an HCC cohort from The Cancer Genome Atlas (TCGA). For prognostic analysis, the TCGA cohort was grouped according to different median boundaries. The key module associated with HCC was adopted by Weighted Gene Co-expression Network analysis (WGCNA). We also analyzed the survival ability, functional enrichment, and potential binding proteins of key lncRNAs. The expression of hub lncRNAs in HCC tissues and cell lines was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Cell Counting Kit-8 (CCK-8) and flow cytometry were applied to detect the cell proliferation, apoptosis, and cell cycle. The interaction between NIFK-AS1 and SRSF1 was examined using an RNA pull-down assay.Results: The green module is the key module in HCC. NIFK-AS1 was highly expressed in HCC tissues and correlated with a poor prognosis in HCC patients (P=0.008). NIFK-AS1 was also significantly associated with cell mitosis, the cell cycle, and other biological processes. NIFK-AS1 deletion prevented cell proliferation, induced apoptosis, caused G2/M arrest, and affected cell cycle progression. RNA pull-down validated the NIFK-AS1/SRSF10 interaction. The overexpression of NIFK-AS1 was sufficient to rescue the growth of SRSF10 knockdown HepG2 cells.Conclusions: This study suggested that NIFK-AS1 promotes HCC cell cycle progression through interaction with SRSF10 and its findings provide new insights into therapeutic targets for HCC.

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Long non-coding RNA XIST: a novel oncogene in multiple cancers

Cited by 40 publications

References 123 publications

Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

The emerging role of long non-coding RNAs in renal cell carcinoma progression and clinical therapy via targeting metabolic regulation

A novel biomarker NIFK-AS1 promotes hepatocellular carcinoma cell cycle progression through interaction with SRSF10

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