Long non-coding RNAs: A new frontier in the study of human diseases

Shi, Xuefei; Sun, Ming; Liu, Hongbing; Yao, Yanwen; Song, Yong

doi:10.1016/j.canlet.2013.06.013

Cited by 1,057 publications

(829 citation statements)

References 102 publications

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“…Recent studies have revealed that lncRNAs are widely expressed in many human tissues and cells, and participate in many important cellular process, such as X chromatin imprinting, stem cells differentiation, immune response, tumor cells growth, and chemotherapy resistance 10, 11. Dysregulation of lncRNAs expression has been found to involve in the development of various human diseases 12. Moreover, lncRNA and gene profiling analyses in a large cohort of multiple types of cancer tissues by high‐throughput RNA sequencing or microarray uncovered that thousands of lncRNAs are differentially expressed in human cancer tissues 13.…”

Section: Introductionmentioning

confidence: 99%

Identification of differential expressed lncRNAs in human thyroid cancer by a genome‐wide analyses

et al. 2018

Cancer Medicine

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Recently, a growing number of evidence has revealed that long noncoding RNAs (lncRNAs) act as key regulators in various cellular biologic processes, and dysregulation of lncRNAs involves in tumorigenesis and cancer progression. However, the expression pattern, clinical relevance, and biologic function of most lncRNAs in human thyroid cancer remain unclear. To identify more thyroid‐cancer‐associated lncRNAs, we analyzed the expression profile of lncRNAs in thyroid cancer tissues and adjacent normal or non‐tumor tissues using RNA sequencing data and gene microarray data from The Cancer Genome Atlas and Gene Expression Omnibus. Annotation and analyses of these data revealed that hundreds of lncRNAs are differentially expressed in thyroid cancer tissues when compared with normal tissues. By copy number variation analyses, we identified that some of those dysregulated lncRNAs genome locus are accompanied with the copy number amplification or deletion. Moreover, some lncRNAs expression levels are significantly associated with thyroid cancer patients overall or recurrence‐free survival time, such as RUNDC3A‐AS1, FOXD2‐AS1, PAX8‐AS1, and CRYM‐AS1. Furthermore, we validated an lncRNA termed LINC00704 in thyroid cancer cells by performing loss of function assays. Downregulation of LINC00704 could significantly impair thyroid cancer cells proliferation, colony formation, inhibit cell‐cycle progression and cell invasion, and induce cell apoptosis. Taken together, our findings reveal that lots of lncRNAs are dysregulated and may play critical roles in thyroid cancer, and this study could provide useful resource for identification and investigation of novel lncRNA candidates for thyroid cancer.

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Section: Introductionmentioning

confidence: 99%

Identification of differential expressed lncRNAs in human thyroid cancer by a genome‐wide analyses

et al. 2018

Cancer Medicine

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“…Recently, a growing number of studies reveal that noncoding RNAs (ncRNAs) as well as protein‐coding genes play important roles in human diseases, especially cancers 6, 7, 8. long noncoding RNAs (lncRNAs) are the new member of ncRNA with a length >200 nt, and lacking of protein‐coding capacity 9.…”

Section: Introductionmentioning

confidence: 99%

A genome‐wide analysis of long noncoding RNA profile identifies differentially expressed lncRNAs associated with Esophageal cancer

et al. 2018

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Esophageal cancer is one of the most common cancers and a leading cause of cancer‐related death worldwide. However, the mechanism of esophageal cancer pathogenesis remains poorly understood. Long noncoding RNAs (lncRNAs) dysregulation have been reported to involve in various human cancers, which highlights the potential of lncRNAs used as novel biomarkers for cancer diagnosis. Although more efforts have been made to identify novel lncRNAs signature in esophageal cancer, the expression pattern, prognostic value, and biological function of most lncRNAs in esophageal cancer still need to be systematically investigated. In this study, we comprehensively analyzed the expression profile of lncRNAs in more than 200 esophageal cancer patients tissue samples from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). We identified thousands of lncRNAs are differentially expressed in esophageal cancer tissues, and many of those lncRNAs expression are associated with patients overall survival or recurrence‐free survival time. Moreover, copy number variation analyses revealed that genomic loci copy number amplification or deletion might contribute to these lncRNAs dysregulation. Among these lncRNAs, DUXAP8 and LINC00460 were significantly upregulated, and GO enrichment analyses indicated that the two lncRNAs associated protein‐coding genes involve with many known biological processes, such as cell cycle and cell‐cell adherens junction. Further experimental validation revealed that knockdown of DUXAP8 could impair esophageal cancer cells proliferation and invasion in vitro. Taken together, our findings identified more aberrantly expressed lncRNAs in esophageal cancer that may provide a useful resource for identifying novel esophageal cancer associated lncRNAs.

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“…Ces ARN non codants comprennent, d'une part, des types d'ARN régulateurs dont les fonctions et les mécanismes d'action impliqués sont relativement bien définis comme les miARN (micro-ARN) et les piARN (piwi-interacting RNA) et, d'autre part, des classes d'ARN moins bien caractéri-sées (comme les longs ARN non codants, lncRNA). Bien que la fonction de la grande majorité des lncRNA reste, à l'heure actuelle, largement inexplorée, il semble que ces transcrits jouent un rôle important dans plusieurs processus physiologiques, tels que la régulation épi-génétique de l'expression génique ou la maturation des ARN messagers [2][3][4][5][6]. De plus, plusieurs travaux récents convergent pour indiquer que certains d'entre eux seraient impliqués dans le développement de pathologies humaines.…”

Section: Une Panoplie D'arn Longs Non Codantsunclassified

“…Les lncRNA peuvent réguler l'expression des gènes par divers mécanismes. Les aspects moléculaires de ces mécanismes ont été détaillés dans des revues récentes [2,4,15]. Les lncRNA peuvent potentiellement lier l'ADN, des protéines ou d'autres ARN, formant des plateformes d'échafaudage et permettant ainsi l'interaction entre diverses molécules fonctionnelles (Figure 4).…”

Section: Fonctions Des Lncrna Dans Les Processus Physiologiquesunclassified

“…En effet, de nombreuses études démontrant une dérégulation des lncRNA dans divers types de cellules cancéreuses suggèrent que les lncRNA peuvent agir comme des suppresseurs de tumeurs ou des oncogènes potentiels [4] (Tableau II). Parmi les exemples de lncRNA associés au cancer, le rôle de HOTAIR a été le plus étudié.…”

Section: Le Rôle Des Lncrna Dans Le Développement Des Maladies Et Desunclassified

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Rôle des longs ARN non codants dans le développement normal et pathologique

et al. 2014

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Long non-coding RNAs: A new frontier in the study of human diseases

Cited by 1,057 publications

References 102 publications

Identification of differential expressed lncRNAs in human thyroid cancer by a genome‐wide analyses

Identification of differential expressed lncRNAs in human thyroid cancer by a genome‐wide analyses

A genome‐wide analysis of long noncoding RNA profile identifies differentially expressed lncRNAs associated with Esophageal cancer

Rôle des longs ARN non codants dans le développement normal et pathologique

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