Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling

Entezari, Maliheh; Ghanbarirad, Maryam; Taheriazam, Afshin; Sadrkhanloo, Mehrdokht; Zabolian, Amirhossein; Goharrizi, Mohammad Ali Shekhi Beig; Hushmandi, Kiavash; Aref, Amir Reza; Ashrafizadeh, Milad; Zarrabi, Ali; Nabavi, Noushin; Rabiee, Navid; Hashemi, Mehrdad; Samarghandian, Saeed

doi:10.1016/j.biopha.2022.112963

Cited by 70 publications

(39 citation statements)

References 277 publications

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“…Furthermore, overexpression of tumour-promoting lncRNAs can manage immune evasion of LC cells 24 . However, this paper will focus on cancer-related lncRNAs and mRNAs.…”

Section: Discussionmentioning

confidence: 99%

Comparative genome-wide analysis of hub lncRNAs and mRNAs in brain metastatic small cell lung cancer – An in-Silico Approach

Namini

Jahangir

Mohseni

et al. 2022

Preprint

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Lung cancer is one of the most commonly prevalent globally. Metastatic lung tumours lead to most deaths in lung cancer. Predicting and preventing tumour metastasis is crucially Important for patient survivability. Hence, in the current study, we focused on a comprehensive analysis of lung cancer patients' differentially expressed genes (DEGs) on brain metastasis cell lines. DEGs are analysed through KEGG and GO databases for the most critical biological processes and pathways for enriched DEGs. Additionally, we performed PPI, GeneMANIA and Kaplan-Meier survival analyses on our DEGs. This article focused on mRNA and lncRNA DEGs for LC patients with brain metastasis and underlying molecular mechanisms. The expression data was gathered from the Gene Expression Omnibus database (GSE161968). We demonstrate that 30 distinct genes are up expressed in brain metastasis SCLC patients, and 31 genes are down-expressed. All the analyses we performed show these genes are Involve In metastatic SCLC. PPI analysis revealed two hub genes (CAT and APP). The results of this article present three lncRNAs, Including XLOC_l2_000941, LOC100507481, and XLOC_l2_007062, also notable mRNAs, have a close relation with brain metastasis in lung cancer and may have a role in the epithelial-mesenchymal transition (EMT) in tumour cells.

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“…Furthermore, overexpression of tumour-promoting lncRNAs can manage immune evasion of LC cells 24 . However, this paper will focus on cancer-related lncRNAs and mRNAs.…”

Section: Discussionmentioning

confidence: 99%

Comparative genome-wide analysis of hub lncRNAs and mRNAs in brain metastatic small cell lung cancer – An in-Silico Approach

Namini

Jahangir

Mohseni

et al. 2022

Preprint

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“… [ 28 ] Inhibited the proliferation of tumor cells. [ 28 ] lncRNA linc00312 Correlated with the clinicopathological status of NSCLC patients [ 29 ] Regulate the expression of transcription factor HOXA5 [ 30 ] Urothelial carcinoma-associated gene 1 (UCA1) Related to the initiation and development of tumors [ 31 , 32 ] RP11-397D12.4, AC007403.1, ERICH1-AS1 A predictive model based on these three abnormally expressing lncRNA [ 33 ] SPRY4-IT1, ANRIL, and NEAT1 The relationship with clinical prognosis [ 7 , 12 , 61 ] Growth arrest-specific transcript 5 (GAS5) A potential biomarker for the diagnosis of NSCLC [ 34 ] MALAT1 The regulation of Oct4 [ 7 ] ZNF503-AS1, CYP4F26P, RP11-108M12.3, RP11-38M8.1 and RP11- 54H7.4 Predicts the 5-year survival of NSCLC [ 62 ] …”

Section: Clinical Application Of Lncrnamentioning

confidence: 99%

“…The relationship with clinical prognosis [7,12,61] Growth arrest-specific transcript 5 (GAS5) A potential biomarker for the diagnosis of NSCLC [34] MALAT1…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…LncRNAs take part in the initiation, and progression of cancer by various mechanisms. Moreover, different lncRNAs are also engaged in regulating sensitivities to chemotherapy, targeted therapy, and even radiotherapy [ 6 , 7 ]. In this review, we summarized the role of lncRNAs in lung cancer progression, discussed the underlying mechanisms driving the related biological process, and prospected the potential application targeting lncRNAs in NSCLC.…”

Section: Introductionmentioning

confidence: 99%

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LncRNA in tumorigenesis of non-small-cell lung cancer: From bench to bedside

Chen

et al. 2022

Cell Death Discov.

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Lung cancer has been one of the leading causes of cancer-related death worldwide, and non-small-cell lung cancer (NSCLC) accounts for the majority of lung cancer morbidity, yet the pathogenesis of NSCLC has not been fully elucidated. Recently, long-chain non-coding RNA (lncRNA) has attracted widespread attention. LncRNA is a type of non-coding RNA whose transcript length exceeds 200 nucleotides. After constant research, academics updated their understanding of lncRNA, especially its role in the biological processes of cancer cells, including epigenetic regulation, cell proliferation, and cell differentiation. Notably, examination of lncRNAs could serve as potential hallmarks for clinicopathological features, long-term prognosis, and drug sensitivity. Therefore, it is necessary to explore the functions of lncRNA in NSCLC and innovate potential strategies against NSCLC based on lncRNA-related research. Herein, we reviewed the functions of lncRNA in the occurrence, diagnosis, treatment, and prognosis of NSCLC, which not only help promote a comprehensive view of lncRNA in NSCLC, but also shed light on the potential of lncRNA-based diagnosis and treatment of NSCLC.

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“…If early lung adenocarcinoma can be found and treated in time, the 5-year survival rate can reach 90% [6]. The occurrence and development of lung adenocarcinoma are affected by many factors [7], but its exact etiological mechanism is still unclear, which greatly limits its further treatment.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of hsa_circ_0061817 Can Inhibit the Proliferation and Invasion of Lung Cancer Cells Based on Active Compounds

Zhong

et al. 2022

Oxidative Medicine and Cellular Longevity

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Objective. This study was aimed at investigating the expression level of hsa_circ_0061817 in lung adenocarcinoma cells and its effect on cell proliferation and invasion and the possible mechanism of hsa_circ_0061817 in lung adenocarcinoma. Methods. The overexpression plasmids of hsa_circ_0061817 (OE-hsacirc_0061817) were transfected into human lung A549 cells and mouse LLC-LUC cells, respectively. The cell viability was detected by CCK-8, and the cell proliferation was detected by cell clone formation assay and EdU assay. Transwell test was used to detect the ability of cell invasion, and apoptosis was detected by flow cytometry. WB was applied to determine the expression of apoptosis and epithelial mesenchymal transition-(EMT-) related proteins and also target proteins for observation the effect of OE-hsa_circ_0061817 on the growth of A549 cells in nude mice. Bioinformatics method was used to predict the binding microRNA (miRNA) of hsa_circ_0061817 and construct the regulatory network of competitive endogenous RNA (ceRNA) and functional analysis of miRNA target genes. Results. Compared with PLO-ciR group, the cell viability, proliferation, and invasive ability of A549 and LLC-LUC were significantly reduced in OE-hsa_circ_00061817 group, while the apoptosis increased in OE-hsa_circ_00061817 group compared to PLO-ciR group. WB results showed that the expression of caspase 3, caspase 7, caspase 9, and E-cadherin increased significantly, while the expression levels of vimentin and N-cadherin decreased severely. Most importantly, OE-hsa_circ_00061817 inhibited the growth of A549 tumor-bearing nude mice. According to TargetScan and mirBase databases, hsa_circ_0061817 may competitively bind hsa_mir-181b-3p, hsa-mir-337-3p, hsa-mir-421, and hsa-mir-548d-3p. The results of functional enrichment showed that miRNA target genes were involved in many cancer-related biological processes, including negative regulation of apoptosis, gene expression, transcriptional imbalance in cancer, transforming growth factor-β, and P53 signal pathway. Conclusions. Over expression of hsa_circ_0061817 inhibits the proliferation of lung adenocarcinoma A549 and LLC-LUC cells and may reduce the invasive ability of lung adenocarcinoma cells by weakening the process of EMT, which provides a new target for the prevention and treatment of lung adenocarcinoma.

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Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling

Cited by 70 publications

References 277 publications

Comparative genome-wide analysis of hub lncRNAs and mRNAs in brain metastatic small cell lung cancer – An in-Silico Approach

Comparative genome-wide analysis of hub lncRNAs and mRNAs in brain metastatic small cell lung cancer – An in-Silico Approach

LncRNA in tumorigenesis of non-small-cell lung cancer: From bench to bedside

Overexpression of hsa_circ_0061817 Can Inhibit the Proliferation and Invasion of Lung Cancer Cells Based on Active Compounds

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