Long non-coding RNAs and rheumatoid arthritis: Pathogenesis and clinical implications

Elazazy, Ola; Midan, Heba M.; Shahin, Reem K.; Elesawy, Ahmed E.; Elballal, Mohammed S.; Sallam, Al-Aliaa M.; Elbadry, Abdullah M.M.; Elrebehy, Mahmoud A.; Bhnsawy, Abdelmenem; Doghish, Ahmed S.

doi:10.1016/j.prp.2023.154512

Cited by 44 publications

(2 citation statements)

References 153 publications

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“…ncRNAs play key roles at the post-transcriptional level in different pathways and diseases, including neurodegenerative disorders ( Nhung Nguyen et al, 2022 ; Salama et al, 2022 ; Elazazy et al, 2023 ) Table 1 . Numerous studies have been conducted on the dynamic ncRNA alterations caused by microglia-induced neuroinflammation (J.…”

Section: Role Of Non-coding Rnas In Microglia (M1/m2) Pathwaymentioning

confidence: 99%

The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases

Darwish,

Elbadry,

Elbokhomy

et al. 2023

Front. Aging

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The pathophysiology of different neurodegenerative illnesses is significantly influenced by the polarization regulation of microglia and macrophages. Traditional classifications of macrophage phenotypes include the pro-inflammatory M1 and the anti-inflammatory M2 phenotypes. Numerous studies demonstrated dynamic non-coding RNA modifications, which are catalyzed by microglia-induced neuroinflammation. Different nutraceuticals focus on the polarization of M1/M2 phenotypes of microglia and macrophages, offering a potent defense against neurodegeneration. Caeminaxin A, curcumin, aromatic-turmerone, myricetin, aurantiamide, 3,6′-disinapoylsucrose, and resveratrol reduced M1 microglial inflammatory markers while increased M2 indicators in Alzheimer’s disease. Amyloid beta-induced microglial M1 activation was suppressed by andrographolide, sulforaphane, triptolide, xanthoceraside, piperlongumine, and novel plant extracts which also prevented microglia-mediated necroptosis and apoptosis. Asarone, galangin, baicalein, and a-mangostin reduced oxidative stress and pro-inflammatory cytokines, such as interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha in M1-activated microglia in Parkinson’s disease. Additionally, myrcene, icariin, and tenuigenin prevented the nod-like receptor family pyrin domain-containing 3 inflammasome and microglial neurotoxicity, while a-cyperone, citronellol, nobiletin, and taurine prevented NADPH oxidase 2 and nuclear factor kappa B activation. Furthermore, other nutraceuticals like plantamajoside, swertiamarin, urolithin A, kurarinone, Daphne genkwa flower, and Boswellia serrata extracts showed promising neuroprotection in treating Parkinson’s disease. In Huntington’s disease, elderberry, curcumin, iresine celosia, Schisandra chinensis, gintonin, and pomiferin showed promising results against microglial activation and improved patient symptoms. Meanwhile, linolenic acid, resveratrol, Huperzia serrata, icariin, and baicalein protected against activated macrophages and microglia in experimental autoimmune encephalomyelitis and multiple sclerosis. Additionally, emodin, esters of gallic and rosmarinic acids, Agathisflavone, and sinomenine offered promising multiple sclerosis treatments. This review highlights the therapeutic potential of using nutraceuticals to treat neurodegenerative diseases involving microglial-related pathways.

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Section: Role Of Non-coding Rnas In Microglia (M1/m2) Pathwaymentioning

confidence: 99%

The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases

Darwish,

Elbadry,

Elbokhomy

et al. 2023

Front. Aging

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“…Depending on their cellular localization, lncRNAs can act as transcriptional enhancers or translational regulators for different cellular processes, such as viability [ 2 , 3 ], cell cycle [ 4 , 5 ] and differentiation [ 6 ]. LncRNAs have also been associated with the development and progression of various pathological conditions, such as cancer [ 7 , 8 ] and autoimmune disorders [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

LncRNAs, nuclear architecture and the immune response

Montano,

Flores-Arenas,

Carpenter

2024

Nucleus

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Long noncoding RNAs (LncRNAs) are key regulators of gene expression and can mediate their effects in both the nucleus and cytoplasm. Some of the best-characterized lncRNAs are localized within the nucleus, where they modulate the nuclear architecture and influence gene expression. In this review, we discuss the role of lncRNAs in nuclear architecture in the context of their gene regulatory functions in innate immunity. Here, we discuss various approaches to functionally characterize nuclear-localized lncRNAs and the challenges faced in the field.

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From diagnosis to resistance: a symphony of miRNAs in pheochromocytoma progression and treatment response

Elsakka,

Elshafei,

Elkady

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Long non-coding RNAs and rheumatoid arthritis: Pathogenesis and clinical implications

Cited by 44 publications

References 153 publications

The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases

The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases

LncRNAs, nuclear architecture and the immune response

From diagnosis to resistance: a symphony of miRNAs in pheochromocytoma progression and treatment response

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