Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma

Parasramka, Mansi; Maji, Sayantan; Matsuda, Akiko; Yan, Irene K.; Patel, Tushar

doi:10.1016/j.pharmthera.2016.03.004

Cited by 177 publications

(149 citation statements)

References 138 publications

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“…Besides these previously reported HCC-related lncRNAs included in the profiler, more than 10 additional lncRNAs have been associated in HCC studies in the past 5 years, which were mostly performed in HBV-related HCC [51]. In our analysis, three lncRNAs, DBH-AS1, hDREH and hPVT1, were differentially expressed according to the viral etiology in HCC.…”

Section: Discussionmentioning

confidence: 74%

Analysis of long noncoding RNA expression in hepatocellular carcinoma of different viral etiology

et al. 2016

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BackgroundDysregulation of long noncoding RNA (lncRNA) expression contributes to the pathogenesis of many human diseases, including liver diseases. Several lncRNAs have been reported to play a role in the development of hepatocellular carcinoma (HCC). However, most studies have analyzed lncRNAs only in hepatitis B virus (HBV)-related HCC or in a single group of HCC patients regardless of the viral etiology.MethodsTo investigate whether lncRNAs are differentially expressed in HCC of different viral etiology, we profiled 101 disease-related lncRNAs, including 25 lncRNAs previously associated with HCC, in liver specimens obtained from well-characterized patients with HBV-, hepatitis C virus (HCV)-, or hepatitis D virus (HDV)-associated HCC.ResultsWe identified eight novel HCC-related lncRNAs that were significantly dysregulated in HCC tissues compared to their surrounding non-tumorous tissues. Some of these lncRNAs were significantly dysregulated predominantly in one specific hepatitis virus-related HCC, including PCAT-29 in HBV-related HCC, aHIF and PAR5 in HCV-related HCC, and Y3 in HDV-related HCC. Among the lncRNAs previously reported in HCC, we found that DBH-AS1, hDREH and hPVT1 were differentially expressed in HCC of different viral etiology.ConclusionsOur study suggests that HCC of different viral etiology is regulated by different lncRNAs. The identification of lncRNAs unique to specific hepatitis virus-related HCC may provide new tools for improving the diagnosis of HCC and open new avenues for disease-specific therapeutic interventions.Electronic supplementary materialThe online version of this article (doi:10.1186/s12967-016-1085-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 74%

Analysis of long noncoding RNA expression in hepatocellular carcinoma of different viral etiology

et al. 2016

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“…As may be expected from their structural diversity, a wide range of biological functions have been described for lncRNAs. These functions primarily include gene transcription, epigenomic regulation, translation of protein‐coding genes, RNA turnover, chromatin organization and genome defence . It is worth noting that most of the functions described to date are implicated in regulation of gene expression, both of protein‐coding genes and other non‐coding RNAs, through a multitude of mechanisms of action as presented in Figure .…”

Section: Biological Functions Of Lncrnasmentioning

confidence: 99%

“…These functions primarily include gene transcription, epigenomic regulation, translation of protein-coding genes, RNA turnover, chromatin organization and genome defence. 20,21 It is worth noting that most of the functions described to date are implicated in regulation of gene expression, both of protein-coding genes and other non-coding RNAs, through a multitude of mechanisms of action as presented in Figure 2. 22 (1) Transcript of a lncRNA across the promoter region of a downstream protein-coding gene is able to directly interfere with RNA polymerase II recruitment, thereby inhibiting the expression of protein-coding gene.…”

Section: Biological Functions Of Lncrnasmentioning

confidence: 99%

lncRNAs: novel players in intervertebral disc degeneration and osteoarthritis

et al. 2016

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The term long non-coding RNA (lncRNA) refers to a group of RNAs with length more than 200 nucleotides, limited protein-coding potential, and having widespread biological functions, including regulation of transcriptional patterns and protein activity, formation of endogenous small interfering RNAs (siRNAs) and natural microRNA (miRNA) sponges. Intervertebral disc degeneration (IDD) and osteoarthritis (OA) are the most common chronic, prevalent and age-related degenerative musculoskeletal disorders. Numbers of lncRNAs are differentially expressed in human degenerative nucleus pulposus tissue and OA cartilage. Moreover, some lncRNAs have been shown to be involved in multiple pathological processes during OA, including extracellular matrix (ECM) degradation, inflammatory responses, apoptosis and angiogenesis. In this review, we summarize current knowledge concerning lncRNAs, from their biogenesis, classification and biological functions to molecular mechanisms and therapeutic potential in IDD and OA. are the most common chronic, prevalent and age-related degenerative musculoskeletal disorders, leading to an enormous socioeconomic burden worldwide. IDD and OA are two major causes of disability and chronic pain, and their incidence has been increasing not only among older persons but also within younger adults in the past decades. It is estimated that approximately 80% adults will suffer chronic low back pain caused by IDD during their lifetime.1 Over 50% of patients with symptomatic OA are younger than 65 years old.

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“…For example, HOXA11AS, UCA1, NEAT1, HOTAIR, and SPRY4-IT1 overexpression contributes to OC development. The oncogenic roles of these lncRNAs could be directly inhibited by employing RNAi techniques, as recently reviewed [28], suggesting remarkable promise as targets for future therapeutic development.…”

Section: Silencing Lncrnas Using Rnai Techniquesmentioning

confidence: 99%

Long Non-Coding RNAs: the New Horizon of Gene Regulation in Ovarian Cancer

Worku

Bhattarai

Ayers

et al. 2017

Cell Physiol Biochem

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Long non-coding RNAs (lncRNAs), a class of non-coding transcripts, have recently been emerging with heterogeneous molecular actions, adding a new layer of complexity to generegulation networks in tumorigenesis. LncRNAs are considered important factors in several ovarian cancer histotypes, although few have been identified and characterized. Owing to their complexity and the lack of adapted molecular technology, the roles of most lncRNAs remain mysterious. Some lncRNAs have been reported to play functional roles in ovarian cancer and can be used as classifiers for personalized medicine. The intrinsic features of lncRNAs govern their various molecular mechanisms and provide a wide range of platforms to design different therapeutic strategies for treating cancer at a particular stage. Although we are only beginning to understand the functions of lncRNAs and their interactions with microRNAs (miRNAs) and proteins, the expanding literature indicates that lncRNA-miRNA interactions could be useful biomarkers and therapeutic targets for ovarian cancer. In this review, we discuss the genetic variants of lncRNAs, heterogeneous mechanisms of actions of lncRNAs in ovarian cancer tumorigenesis, and drug resistance. We also highlight the recent developments in using lncRNAs as potential prognostic and diagnostic biomarkers. Lastly, we discuss potential approaches for linking lncRNAs to future gene therapies, and highlight future directions in the field of ovarian cancer research.

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Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma

Cited by 177 publications

References 138 publications

Analysis of long noncoding RNA expression in hepatocellular carcinoma of different viral etiology

Analysis of long noncoding RNA expression in hepatocellular carcinoma of different viral etiology

lncRNAs: novel players in intervertebral disc degeneration and osteoarthritis

Long Non-Coding RNAs: the New Horizon of Gene Regulation in Ovarian Cancer

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