2015
DOI: 10.1074/jbc.m114.610915
|View full text |Cite|
|
Sign up to set email alerts
|

Long Non-coding RNAs (LncRNA) Regulated by Transforming Growth Factor (TGF) β

Abstract: Background: Long noncoding RNAs (LncRNA) are emerging as key regulators in various biological processes. However, their role in epithelial-to-mesenchymal transition (EMT) remains elusive. Results: A subset of lncRNAs are dysregulated upon transforming growth factor (TGF) ␤-induced EMT, and lncRNA-HIT mediates this process. Conclusion: LncRNAs such as lncRNA-HIT ((HOXA transcript induced by TGF␤) play a pivotal role in EMT and breast cancer progression. Significance: Here we profiled lncRNAs in TGF␤-induced EMT… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
62
0

Year Published

2016
2016
2024
2024

Publication Types

Select...
10

Relationship

1
9

Authors

Journals

citations
Cited by 133 publications
(62 citation statements)
references
References 28 publications
0
62
0
Order By: Relevance
“…LncRNA, as an emerged crucial regulators of various biological processes, present strong ability to link different signal pathway together, and supplement the signal network of cancer [32]. For example, the TGF-β1-upregulated lncRNA malat1 can active PI3K/AKT pathway and promote the proliferation and invasion of human osteosarcoma [3335]. For the genome location of NKILA just besides PMEPA1, which has been proven being upregulated by TGF-β [15, 36],and play an important role in NSCLC [37, 38].…”
Section: Discussionmentioning
confidence: 99%
“…LncRNA, as an emerged crucial regulators of various biological processes, present strong ability to link different signal pathway together, and supplement the signal network of cancer [32]. For example, the TGF-β1-upregulated lncRNA malat1 can active PI3K/AKT pathway and promote the proliferation and invasion of human osteosarcoma [3335]. For the genome location of NKILA just besides PMEPA1, which has been proven being upregulated by TGF-β [15, 36],and play an important role in NSCLC [37, 38].…”
Section: Discussionmentioning
confidence: 99%
“…The expression of hundreds of lncRNAs is regulated during activation of EMT by TGF-β [230,395]. Many of the lncRNAs upregulated by TGF-β seem to be important in the downstream activation genes involved in EMT, including expression of EMT associated TFs (Table 1).…”
Section: Lncrnas In Signalling Pathways Governing Emtmentioning
confidence: 99%
“…Cell migration and invasion assays were performed as described previously (38). Cell cycle analysis was performed using PI staining and followed by flow cytometry.…”
Section: Methodsmentioning
confidence: 99%