Long Non-Coding RNAs, Ubiquitin Proteasome System, Collagen Degradation and Preterm Premature Rupture of Membrane

Wang, Nanbert Zhong Leilei

doi:10.4172/2169-0111.1000117

Cited by 2 publications

(2 citation statements)

References 133 publications

(164 reference statements)

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“…In the current study, we analyzed the DEPs of the lncRNAs and the mRNAs that are associated with the CUP pathway that may also associate with PPROM (Zhong et al, 2015). We also identified gene mutations/variations among sPTBs, although a larger sample size will be needed to make a definitive conclusion.…”

Section: Discussionmentioning

confidence: 99%

“…On the basis of these findings, we hypothesized that the epigenetic regulatory role of lncRNAs in the ubiquitin proteasome system (UPS) and collagen remodeling is that they are involved in the CUP pathway in sPTB, including PPROM (Zhong et al, 2015). To test our hypothesis, we studied the lncRNAs and lncRNA-associated messenger RNAs (mRNAs) and identified gene mutations/variations associated with the CUP pathway.…”

Section: Introductionmentioning

confidence: 99%

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Ubiquitin-Proteasome-Collagen (CUP) Pathway in Preterm Premature Rupture of Fetal Membranes

et al. 2017

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Spontaneous preterm birth (sPTB) occurs before 37 gestational weeks, with preterm premature rupture of the membranes (PPROM) and spontaneous preterm labor (sPTL) as the predominant adverse outcomes. Previously, we identified altered expression of long non-coding RNAs (lncRNAs) and message RNAs (mRNAs) related to the ubiquitin proteasome system (UPS) in human placentas following pregnancy loss and PTB. We therefore hypothesized that similar mechanisms might underlie PPROM. In the current study, nine pairs of ubiquitin-proteasome-collagen (CUP) pathway–related mRNAs and associated lncRNAs were found to be differentially expressed in PPROM and sPTL. Pathway analysis showed that the functions of their protein products were inter-connected by ring finger protein. Twenty variants including five mutations were identified in CUP-related genes in sPTL samples. Copy number variations were found in COL19A1, COL28A1, COL5A1, and UBAP2 of sPTL samples. The results reinforced our previous findings and indicated the association of the CUP pathway with the development of sPTL and PPROM. This association was due not only to the genetic variation, but also to the epigenetic regulatory function of lncRNAs. Furthermore, the findings suggested that the loss of collagen content in PPROM could result from degradation and/or suppressed expression of collagens.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%