Long non‐coding <scp>RNA</scp>s in rheumatoid arthritis

Zheng, Li; Li, Xingye; Jiang, Chao; Qian, Wenwei; Tse, Gary; Chan, Matthew T. V.; Wu, William Ka Kei

doi:10.1111/cpr.12404

Cited by 69 publications

(30 citation statements)

References 53 publications

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“…Previous researchers have identified differentially expressed lncRNAs in PBMCs and synovial fibroblasts in patients with RA, a chronic inflammatory joint disease [ 29 , 30 , 31 , 32 ]. While the functions of most of these lncRNAs remains unknown, Hotair has been reported to enhance the migration of activated macrophages, thereby participating in RA pathogenesis [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

lncRNA NTT/PBOV1 Axis Promotes Monocyte Differentiation and Is Elevated in Rheumatoid Arthritis

Yang

Yen

et al. 2018

IJMS

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Monocytes/macrophages are important in orchestrating inflammatory responses. However, knowledge of the long noncoding RNA (lncRNA) regulation of monocytic cell differentiation and diseases remains limited. We aimed to elucidate the role of the 17 kb lncRNA noncoding transcript in T cells (NTT) in monocyte functions. Knockdown and chromatin immunoprecipitation (ChIP) assays in THP-1 cells (human monocytic leukemia cell line) revealed that NTT is regulated by the monocyte key transcription factor C/EBPβ and that it binds to the promoter of nearby gene PBOV1 via hnRNP-U. Overexpression of PBOV1 in THP-1 cells resulted in cell cycle G1 arrest, differentiation into macrophages, a marked increase in IL-10 and CXCL10 mRNA levels, and upregulation of the costimulatory molecules. In contrast to the downregulated NTT observed in lipopolysaccharide (LPS)-treated THP-1 cells, the C/EBPβ/NTT/PBOV1 axis was found to be hyperactivated in peripheral blood mononuclear cells (PBMCs) of first-time diagnosed untreated early rheumatoid arthritis (RA) patients, and their gene expression levels decreased markedly after treatment. Higher initial C/EBPβ/NTT/PBOV1 expression levels were associated with a trend of higher disease activity DAS28 scores. In conclusion, our study suggests that the lncRNA NTT is a regulator of inflammation in monocytes, and its activation participates in monocyte/macrophage differentiation and the pathogenesis of RA.

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Section: Discussionmentioning

confidence: 99%

lncRNA NTT/PBOV1 Axis Promotes Monocyte Differentiation and Is Elevated in Rheumatoid Arthritis

Yang

Yen

et al. 2018

IJMS

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“…Numerous studies have confirmed that lncRNAs participate in the initiation and progression of several types of bone diseases including bone tumors (27), osteoarthritis (OA) (28,29), osteoporosis (30,31), RA (32) and ankylosing spondylitis (AS) (33). MEG3 has been shown to be involved in the development of the all these bone diseases, as shown in Table II. MEG3 and bone tumors.…”

Section: Roles Of Lncrna Meg3 In Bone Diseasesmentioning

confidence: 95%

Long non‑coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)

Sun

Peng

et al. 2020

Biomed Rep

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Osteogenic differentiation originating from mesenchymal stem cells (MSCs) requires tight coordination of transcriptional factors, signaling pathways and biomechanical cues. Dysregulation of such reciprocal networks may influence the proliferation and apoptosis of MSCs and osteoblasts, thereby impairing bone metabolism and homeostasis. An increasing number of studies have shown that long non-coding (lnc)RNAs are involved in osteogenic differentiation and thus serve an important role in the initiation, development, and progression of bone diseases such as tumors, osteoarthritis and osteoporosis. It has been reported that the lncRNA, maternally expressed gene 3 (MEG3), regulates osteogenic differentiation of multiple MSCs and also acts as a critical mediator in the development of bone formation and associated diseases. In the present review, the proposed mechanisms underlying the roles of MEG3 in osteogenic differentiation and its potential effects on bone diseases are discussed. These discussions may help elucidate the roles of MEG3 in osteogenic differentiation and highlight potential biomarkers and therapeutic targets for the treatment of bone diseases. Contents 1. Introduction 2. Roles of lncRNA MEG3 in osteogenic differentiation 3. Roles of lncRNA MEG3 in bone diseases 4. Conclusion

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“…RNAs with >200 nucleotides in length. [17][18][19] Accumulating evidence suggested that lncRNAs are deregulated in most, if not all, types of human diseases, including tumours, cardiovascular diseases, autoimmune diseases and congenital abnormalities. [20][21][22][23][24] Mechanistically, lncRNAs modulate gene expression at transcriptional and post-transcriptional levels and participate in the regulation of a plethora of molecular, cellular and tissue processes, including DNA synthesis, chromatin modification, cell proliferation, apoptosis, differentiation and organ development.…”

Section: Long Non-coding Rnas (Lncrnas) Are a Group Of Non-codingmentioning

confidence: 99%

Aberrantly expressed long non‐coding RNAs in air pollution‐induced congenital defects

Zheng

et al. 2019

J Cellular Molecular Medi

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Air pollution has been a serious public health issue over the past few decades particularly in developing countries. Air pollution exposure during pregnancy poses potential threat to offspring as the deleterious substances might pass through placenta to alter foetal development. A growing number of studies have demonstrated that long non‐coding RNAs (lncRNAs) participate in the development of many diseases, including congenital defects. Here, we used RNA sequencing to identify differentially expressed lncRNAs in air pollution‐exposed rat embryos compared with control group. Our data suggested that 554 lncRNAs (216 up‐regulated and 338 down‐regulated) were significantly differentially expressed in the air pollution‐exposed embryos. Moreover, potential cellular functions of these deregulated lncRNAs were predicted via KEGG signal pathway/GO enrichment analyses, which suggested the possible involvements of neurological process, sensory perception of smell and the G‐protein signalling pathway. Furthermore, potential functional network of deregulated lncRNAs and their correlated mRNAs in the development of congenital spinal abnormality was established. Our data suggested that lncRNAs may play a vital role in the pathophysiology of air pollution‐exposed congenital spinal malformation.

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Long non‐coding RNAs in rheumatoid arthritis

Cited by 69 publications

References 53 publications

lncRNA NTT/PBOV1 Axis Promotes Monocyte Differentiation and Is Elevated in Rheumatoid Arthritis

lncRNA NTT/PBOV1 Axis Promotes Monocyte Differentiation and Is Elevated in Rheumatoid Arthritis

Long non‑coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)

Aberrantly expressed long non‐coding RNAs in air pollution‐induced congenital defects

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