Long noncoding RNA AURKAPS1 potentiates malignant hepatocellular carcinoma progression by regulating miR-142, miR-155 and miR-182

Li, Jianhua; Guo, Wenzhi; Xue, Wenping; Xu, Pengfei; Deng, Zhen; Zheng, Shusen; Qiu, Xinguang

doi:10.1038/s41598-019-56036-3

Cited by 19 publications

(14 citation statements)

References 40 publications

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“…The cross-regulation between lncRNAs and miRNAs has been demonstrated. lncRNAs may serve as ceRNAs to modulate the expression and functions of miRNAs, and thus have been termed are ‘miRNA sponges’ ( 32 , 33 ). To understand the potential oncogenic mechanisms of LINC00665 in glioma cells, the starBase bioinformatics database was utilized to identify miR-34a-5p as a target of LINC00665 .…”

Section: Discussionmentioning

confidence: 99%

LINC00665 functions as a competitive endogenous RNA to regulate AGTR1 expression by sponging miR‑34a‑5p in glioma

et al. 2021

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Glioma is the most aggressive tumor of the central nervous system. Long non-coding RNAs (lncRNAs) may be involved in modulating tumor generation. The present study analyzed an lncRNA microarray of glioma and selected long intergenic non-protein coding RNA 665 ( LINC00665 ) as the research object. The mode of expression and biological function of LINC00665 in glioma were assessed using lncRNA microarray and RT-qPCR analyses. Gain-of-function assays and/or loss-of-function assays were implemented to explore the role of LINC00665 in the progression of glioma. Dual-luciferase reporter and RNA immunoprecipitation assays explored the downstream molecular mechanism of LINC00665 . The function of the molecular pathway in progression of glioma was analyzed using rescue assays. High expression of LINC00665 was marked in glioma tissues and cells, which correlated with an unsatisfactory prognosis. Upregulation of LINC00665 significantly promoted the proliferation and invasion of glioma cells. LINC00665 acted as a competing endogenous RNA by sponging miR-34a-5p to upregulate angiotensin II receptor type 1 (AGTR1). LINC00665 promoted the progression of glioma by acting as a competitive endogenous RNA to competitively bind to miR-34a-5p and mediate AGTR1 expression.

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Section: Discussionmentioning

confidence: 99%

LINC00665 functions as a competitive endogenous RNA to regulate AGTR1 expression by sponging miR‑34a‑5p in glioma

et al. 2021

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“…For example, some lncRNAs were demonstrated to be deregulated in LCSCs and HSCs and could cause the activation of HCC initiation and fibrosis, such as HULC and ANRIL [61,62]. Likewise, lncRNAs can also participate in tumor growth and metastasis, through regulating EMT, cells proliferation and apoptosis [63][64][65]. Most of these lncRNAs could serve their functions by regulating the expression of target genes, including protein-coding genes or other non-coding RNAs [66].…”

Section: Lncrnas and The Mechanisms Of Hcc Tumorigenesismentioning

confidence: 99%

Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma

et al. 2020

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Hepatocellular carcinoma (HCC) is a type of liver cancer with poor prognosis. There have been demonstrated to exist many possible mechanisms in HCC tumorigenesis, and recent investigations have provided some promising therapy targets. However, further mechanisms remain to be researched to improve the therapeutic strategy and diagnosis of HCC. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine which plays critical roles in networks of different cellular processes, and TGF-β signaling has been found to participate in tumor initiation and development of HCC in recent years. Moreover, among the molecules and signaling pathways, researchers paid more attention to lncRNAs (long non-coding RNAs), but the connection between lncRNAs and TGF-βremain poorly understood. In this review, we conclude the malignant procedure which lncRNAs and TGF-β involved in, and summarize the mechanisms of lncRNAs and TGF-βin HCC initiation and development. Furthermore, the interaction between lncRNA and TGF-β are paid more attention, and the potential therapy targets are mentioned.

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“…Li et al reported that AURKAPS1 expression in 124 cases of HCC tissues was significantly higher than in adjacent normal liver tissues. Additionally, the expression level of AURKAPS1 was positively correlated with tumor size ( p < 0.006) and TNM stage ( p < 0.046), confirming its carcinogenic role [ 171 ]. AURKAPS1 increased HCC cell migration and invasion through competitive binding to miR-142, miR-155, and miR-182, promoting the expression of their target RAC1.…”

Section: Introductionmentioning

confidence: 99%

“…Compared with the AURKA gene, AURKAPS1 has the absence of a 359–560 coding sequence region, and differences in the 3′-terminal nucleotide sequence and nucleotide mutations. To date, the function and abnormal expression of AURKAPS1 in cancerous tissues have been reported in few articles [ 171 ]. Li et al reported that AURKAPS1 expression in 124 cases of HCC tissues was significantly higher than in adjacent normal liver tissues.…”

Section: Introductionmentioning

confidence: 99%

RHO GTPase-Related Long Noncoding RNAs in Human Cancers

Saliani

Mirzaiebadizi

Mosaddeghzadeh

et al. 2021

Cancers

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RHO GTPases are critical signal transducers that regulate cell adhesion, polarity, and migration through multiple signaling pathways. While all these cellular processes are crucial for the maintenance of normal cell homeostasis, disturbances in RHO GTPase-associated signaling pathways contribute to different human diseases, including many malignancies. Several members of the RHO GTPase family are frequently upregulated in human tumors. Abnormal gene regulation confirms the pivotal role of lncRNAs as critical gene regulators, and thus, they could potentially act as oncogenes or tumor suppressors. lncRNAs most likely act as sponges for miRNAs, which are known to be dysregulated in various cancers. In this regard, the significant role of miRNAs targeting RHO GTPases supports the view that the aberrant expression of lncRNAs may reciprocally change the intensity of RHO GTPase-associated signaling pathways. In this review article, we summarize recent advances in lncRNA research, with a specific focus on their sponge effects on RHO GTPase-targeting miRNAs to crucially mediate gene expression in different cancer cell types and tissues. We will focus in particular on five members of the RHO GTPase family, including RHOA, RHOB, RHOC, RAC1, and CDC42, to illustrate the role of lncRNAs in cancer progression. A deeper understanding of the widespread dysregulation of lncRNAs is of fundamental importance for confirmation of their contribution to RHO GTPase-dependent carcinogenesis.

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Long noncoding RNA AURKAPS1 potentiates malignant hepatocellular carcinoma progression by regulating miR-142, miR-155 and miR-182

Cited by 19 publications

References 40 publications

LINC00665 functions as a competitive endogenous RNA to regulate AGTR1 expression by sponging miR‑34a‑5p in glioma

LINC00665 functions as a competitive endogenous RNA to regulate AGTR1 expression by sponging miR‑34a‑5p in glioma

Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma

RHO GTPase-Related Long Noncoding RNAs in Human Cancers

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