Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins

Hirano, Tetsuo; Tsuruda, Tomomi; Tanaka, Yuka; Harada, Hironori; Yamazaki, Takeshi; Ishida, Atsuhiko

doi:10.1016/j.bbamcr.2020.118931

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…SNP rs11787407 ( Figure S8 ) is an intergenic variant nearby gene LINC00976/CCDC26 , a long noncoding RNA that is related to cancers, 77 though its functions remain to be elucidated. It is suggested that rs987525, located near CCDC26 , increases the risk of nonsyndromic CL/P.…”

Section: Discussionmentioning

confidence: 99%

DeepFace: Deep-learning-based framework to contextualize orofacial-cleft-related variants during human embryonic craniofacial development

Dai,

Itai,

Pei

et al. 2024

Human Genetics and Genomics Advances

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Section: Discussionmentioning

confidence: 99%

DeepFace: Deep-learning-based framework to contextualize orofacial-cleft-related variants during human embryonic craniofacial development

Dai,

Itai,

Pei

et al. 2024

Human Genetics and Genomics Advances

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“…CCDC26 is a long non-coding RNA gene, which modulates retinoic acid, which in turn increases apoptosis (controlled cell death). Absence of apoptosis may result in cancer, while excessive apoptosis may result in a cell death of vital cells causing neurodegenerative diseases ( Hirano et al, 2021 ). The present study did not support the hypothesis that the SNP rs7833174 located between CCDC26 and GSDMC is associated with LBP with radiculopathy 12 months after an acute episode of LBP with radiculopathy.…”

Section: Discussionmentioning

confidence: 99%

Low Back Pain With Persistent Radiculopathy; the Clinical Role of Genetic Variants in the Genes SOX5, CCDC26/GSDMC and DCC

et al. 2022

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In a recently published genome-wide association study (GWAS) chronic back pain was associated with three loci; SOX5, CCDC26/GSDMC and DCC. This GWAS was based on a heterogeneous sample of back pain disorders, and it is unknown whether these loci are of clinical relevance for low back pain (LBP) with persistent radiculopathy. Thus, we examine if LBP with radiculopathy 12 months after an acute episode of LBP with radiculopathy is associated with the selected single nucleotide polymorphisms (SNPs); SOX5 rs34616559, CCDC26/GSDMC rs7833174 and DCC rs4384683. In this prospective cohort study, subjects admitted to a secondary health care institution due to an acute episode of LBP with radiculopathy, reported back pain, leg pain, and Oswestry Disability Index (ODI), were genotyped and followed up at 12 months (n = 338). Kruskal-Wallis H test showed no association between the SNPs and back pain, leg pain or ODI. In conclusion, LBP with radiculopathy 12 months after an acute episode of LBP with radiculopathy, is not associated with the selected SNPs; SOX5 rs34616559, CCDC26/GSDMC rs7833174 and DCC rs4384683. This absent or weak association suggests that the SNPs previously associated with chronic back pain are not useful as prognostic biomarkers for LBP with persistent radiculopathy.

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Exploring Novel Strategies to Alleviate Symptoms of β-Globinopathies: Examining the Potential Role of Embryonic ε-globin Induction

Liu,

Park,

Shen

et al. 2024

Transfusion Medicine Reviews

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Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins

Cited by 4 publications

References 43 publications

DeepFace: Deep-learning-based framework to contextualize orofacial-cleft-related variants during human embryonic craniofacial development

DeepFace: Deep-learning-based framework to contextualize orofacial-cleft-related variants during human embryonic craniofacial development

Low Back Pain With Persistent Radiculopathy; the Clinical Role of Genetic Variants in the Genes SOX5, CCDC26/GSDMC and DCC

Exploring Novel Strategies to Alleviate Symptoms of β-Globinopathies: Examining the Potential Role of Embryonic ε-globin Induction

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