Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis

Rupaimoole, Rajesha; Lee, Jae-Hyuk; Haemmerle, Monika; Ling, Hui; Previs, Rebecca A.; Pradeep, Sunila; Wu, Sherry Y.; Ivan, Cristina; Ferracin, Manuela; Dennison, Jennifer B.; Millward, Niki Zacharias; Nagaraja, Archana S.; Gharpure, Kshipra M.; McGuire, Michael H.; Sam, Nidhin; Armaiz-Pena, Guillermo N.; Sadaoui, Nouara C.; Rodríguez-Aguayo, Cristian; Calin, George A.; Drapkin, Ronny; Kovacs, Jeffery; Mills, Gordon B.; Zhang, Wei; López-Berestein, Gabriel; Bhattacharya, Pratip K.; Sood, Anil K.

doi:10.1016/j.celrep.2015.11.047

Cited by 95 publications

(84 citation statements)

References 30 publications

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“…It has been shown to be significantly up-regulated in ovarian tumors [28] . Unlike control cancer cells, the knockdown of NRCP increased apoptosis, decreased cell proliferation, decreased glycolysis, and reduced migration.…”

Section: Non-coding Rna Ceruloplasmin (Nrcp)mentioning

confidence: 99%

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The Role of Long Non-Coding RNAs in Ovarian Cancer

Nikpayam

Tasharrofi

Sarrafzadeh

et al. 2017

IBJ

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Background: Ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. Various studies have already identified suitable biomarkers to facilitate the early detection, prognosis evaluation, and the assessment of treatment response. However, the aim of this review was to investigate the role of long non-coding RNAs (lncRNAs) in tumorigenesis process of ovarian cancer and their potential applications as ovarian cancer biomarkers. Methods: We performed an online literature search of the MEDLINE/PubMed databases using the key words ovarian cancer, lncRNA, and biomarker. Results: We found that several lncRNAs have been shown to be deregulated in ovarian cancer and the specific mechanism of their enrollment in ovarian cancer has been defined for a few of them. In addition, expression profiling has revealed an association between lncRNAs and patients' survival, metastasis potential as well as treatment response. Conclusions: Expression profiling as well as methylation analysis of lncRNAs in ovarian cancer may lead to the identification of novel biomarkers that can help in the classification of patients based on prognosis and treatment response.

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Section: Non-coding Rna Ceruloplasmin (Nrcp)mentioning

confidence: 99%

“…Unlike control cancer cells, the knockdown of NRCP increased apoptosis, decreased cell proliferation, decreased glycolysis, and reduced migration. In addition, siRNA-mediated silencing of NRCP has reduced tumor growth in an orthotopic mouse model of ovarian cancer [28] .…”

Section: Non-coding Rna Ceruloplasmin (Nrcp)mentioning

confidence: 99%

The Role of Long Non-Coding RNAs in Ovarian Cancer

Nikpayam

Tasharrofi

Sarrafzadeh

et al. 2017

IBJ

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show abstract

“…However, the role of lncRNAs in mediating BCBM is still unclear. Targeting of lncRNAs using locked nucleic acids or a siRNA-based strategy has been successfully applied in several preclinical models (12,14). Here, we report that elevated expression of an lncRNA we refer to as Lnc-BM (long noncoding for brain metastasis) in primary breast cancer exhibits higher rates of recurrence to the brain.…”

Section: Introductionmentioning

confidence: 99%

JAK2-binding long noncoding RNA promotes breast cancer brain metastasis

Wang¹,

Liang²,

Hu³

et al. 2017

Journal of Clinical Investigation

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190

146

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“…Nonetheless, some studies have reported that lncRNAs can regulate carbohydrate metabolism progression in cancers. For instance, lncRNA GCASPC regulate glycolysis in cancer cells by directly binding with key glycolytic enzymes [30] and lncRNA NRCP is an intermediate binding partner between STAT1 and RNA polymerase II, leading to increased expression of glucose-6-phosphate isomerase [31]. Zhao et al reported that LINC00092 interacts with 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2 (PFKFB2) and is involved in increased glycolysis levels in ovarian cancer metastasis [32].…”

Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA Profiling from Fasciola Gigantica Excretory/Secretory Product-Induced M2 to M1 Macrophage Polarization

Luo

Zhang

Sheng

et al. 2018

Cell Physiol Biochem

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Background/Aims: Long noncoding RNAs (lncRNAs) are well known regulators of gene expression that play essential roles in macrophage activation and polarization. However, the role of lncRNA in Fasciola gigantica excretory/secretory products (ESP)-induced M2 polarization into M1 macrophages is unclear. Herein, we performed lncRNA profiling of lncRNAs and mRNAs during the ESP-induced macrophage polarization process. Methods: F. gigantica ESP was used to induce peritoneal cavity M2 macrophages in BALB/c mice (5-6 weeks old) in vivo, and these cells were subsequently isolated and stimulated with IFN-γ + LPS to induce M1 cells in vitro. LncRNA and mRNA profiling was performed via microarray at the end of both polarization stages. Results: In total, 2,844 lncRNAs (1,579 upregulated and 1,265 downregulated) and 1,782 mRNAs (789 upregulated and 993 downregulated) were differentially expressed in M2 macrophages compared to M1 macrophages, and six lncRNAs were identified during polarization. We selected 34 differentially expressed lncRNAs and mRNAs to validate the results of microarray analysis using quantitative real-time PCR (qPCR). Pathway and Gene Ontology (GO) analyses demonstrated that these altered transcripts were involved in multiple biological processes, particularly peptidase activity and carbohydrate metabolism. Furthermore, coding and non-coding gene (CNC) and mRNA-related ceRNA network analyses were conducted to predict lncRNA expression trends and the potential target genes of these lncRNAs and mRNAs. Moreover, we determined that four lncRNAs and four mRNAs might participate in F. gigantica ESP-induced M2 polarization into M1 macrophages. Conclusions: This study illustrates the basic profiling of lncRNAs and mRNAs during F. gigantica ESP-induced M2 polarization into M1 macrophages and deepens our understanding of the mechanism underlying this process.

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Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis

Cited by 95 publications

References 30 publications

The Role of Long Non-Coding RNAs in Ovarian Cancer

The Role of Long Non-Coding RNAs in Ovarian Cancer

JAK2-binding long noncoding RNA promotes breast cancer brain metastasis

Long Noncoding RNA Profiling from Fasciola Gigantica Excretory/Secretory Product-Induced M2 to M1 Macrophage Polarization

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