Long noncoding‐RNA component of mitochondrial RNA processing endoribonuclease is involved in the progression of cholangiocarcinoma by regulating microRNA‐217

Tang, Ling-Yu; Wang, Yuting; Wang, Huishan; Xu, Boming; Ji, Hao; Xu, Guolong; Ge, Xianxiu; Li, Quanpeng; Ma, Lin

doi:10.1111/cas.14074

Cited by 23 publications

(25 citation statements)

References 30 publications

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“…Elevated levels of RMRP have been observed in different cancers, in one case as a result of transcriptional activation of the RMRP gene by the Wnt pathway through binding of YAP and β-catenin to the TATA box of the RMRP promoter (Park and Jeong 2015). High RMRP expression has been associated with poor patient prognosis and consistent with this, RMRP knockdown and overexpression experiments in various cancer cell lines revealed a positive role in cell proliferation and tumorigenic potential (Meng et al 2016;Shao et al 2016;Cao et al 2019;Hongfeng et al 2019;Pan et al 2019;Tang et al 2019;Wang et al 2019a,b;Xiao et al 2019).…”

Section: Rmrp In Cancermentioning

confidence: 82%

“…In cholangiocarcinoma cells, knockdown of RMRP led to differential expression of 729 miRNAs as determined by high-throughput sequencing. Among them, miR-217, previously implicated in tumor suppression, was shown to contribute to the oncogenic potential of RMRP (Tang et al 2019). In multiple myeloma cells, a positive feedback loop consisting of c-Myc, RMRP, and miR-34a-5p was identified.…”

Section: Rmrp In Cancermentioning

confidence: 99%

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RNA polymerase III transcription as a disease factor

Yeganeh

Hernandez

2020

Genes Dev.

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RNA polymerase (Pol) III is responsible for transcription of different noncoding genes in eukaryotic cells, whose RNA products have well-defined functions in translation and other biological processes for some, and functions that remain to be defined for others. For all of them, however, new functions are being described. For example, Pol III products have been reported to regulate certain proteins such as protein kinase R (PKR) by direct association, to constitute the source of very short RNAs with regulatory roles in gene expression, or to control microRNA levels by sequestration. Consistent with these many functions, deregulation of Pol III transcribed genes is associated with a large variety of human disorders. Here we review different human diseases that have been linked to defects in the Pol III transcription apparatus or to Pol III products imbalance and discuss the possible underlying mechanisms.

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Section: Rmrp In Cancermentioning

confidence: 82%

Section: Rmrp In Cancermentioning

confidence: 99%

RNA polymerase III transcription as a disease factor

Yeganeh

Hernandez

2020

Genes Dev.

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“…Recently, lncRNAs have gained great attention as its role in CCA 15 . Several known lncRNAs were reported to be dysregulated in CCA tissues and involved in the CCA development and progression, such as DANCR 16 , PVT1 17 , and RMRP 18 . Recent studies have reported that SNHG6 is highly expressed in variety of cancer tissues (except CCA) and .…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA SNHG6 promotes proliferation and angiogenesis of cholangiocarcinoma cells through sponging miR-101-3p and activation of E2F8

Wang¹,

Wang²,

Tang³

et al. 2020

J. Cancer

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Cholangiocarcinoma (CCA) development is an extremely complex process with alterations occurring in numerous genes. SNHG6, a validated lncRNA, has been reported to regulate the expression of multiple tumor-related genes in hepatocellular carcinoma, colorectal cancer and breast cancer. Here, we elucidated the function and possible molecular mechanisms of SNHG6 in human CCA cells. Our results proved that the expression SNHG6 was upregulated in CCA tissues and cell lines. Ectopic expression of SNHG6 promoted cell proliferation, cell cycle progression, migration, and angiogenesis in CCA cells, whereas knockdown of SNHG6 repressed these cellular processes. Further mechanistic studies revealed that SNHG6 could compete with the transcription factor E2F8 to bind with miR-101-3p, thus affecting E2F8 expression. Taken together, these results provided a comprehensive analysis of the role of SNHG6 in CCA cells and offered important clues to understand the key roles of competing endogenous RNA (ceRNA) mechanisms in human cholangiocarcinoma.

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“…miRNAs perform as antiregulators of gene expression (Giuliani et al, 2017). Interestingly, there are so many miRNAs that play an important role in the mitochondrial diseases and dysfunctions, for example, miR-122, miR-762, and miR-217 (Tang et al, 2019;Wang et al, 2019;Yan et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Biological and Clinical Relevance of microRNAs in Mitochondrial Diseases/Dysfunctions

Sekar

Johnson

Biruntha

et al. 2020

DNA and Cell Biology

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Mitochondrial dysfunction arises from an inadequate number of mitochondria, an inability to provide necessary substrates to mitochondria, or a dysfunction in their electron transport and a denosine triphosphate synthesis machinery. Occurrences of mitochondrial dysfunction are due to genetic or environmental changes in the mitochondria or in the nuclear DNA that codes mitochondrial components. Currently, drug options are available, yet no treatment exists in sight of this disease and needs a new insight into molecular and signaling pathways for this disease. microRNAs (miRNAs) are small, endogenous, and noncoding RNAs function as a master regulator of gene expression. The evolution of miRNAs in the past two decades emerged as a key regulator of gene expression that controls physiological pathological cellular differentiation processes, and metabolic homeostasis such as development and cancer. It has been known that miRNAs are a potential biomarker in both communicable and noncommunicable diseases. But, in the case of mitochondrial dysfunction in miRNAs, the number of studies and investigations are comparatively less than those on other diseases and dysfunctions. In this review, we have elaborated the roles of miRNAs in the mitochondrial diseases and dysfunctions.

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Long noncoding‐RNA component of mitochondrial RNA processing endoribonuclease is involved in the progression of cholangiocarcinoma by regulating microRNA‐217

Cited by 23 publications

References 30 publications

RNA polymerase III transcription as a disease factor

RNA polymerase III transcription as a disease factor

Long noncoding RNA SNHG6 promotes proliferation and angiogenesis of cholangiocarcinoma cells through sponging miR-101-3p and activation of E2F8

Biological and Clinical Relevance of microRNAs in Mitochondrial Diseases/Dysfunctions

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