Long noncoding RNA GIHCG enhanced tongue squamous cell carcinoma progression through regulating miR‐429

Abstract

Long noncoding RNAs play essential roles in cancer development and progression. Here, we tried to investigate the role of GIHCG in the progression and metastasis of tongue squamous cell carcinoma (TSCC). In our study, we showed that that the expression level of GIHCG was upregulated in TSCC tissues and cell lines. In addition, we indicated that high GIHCG expression was positively associated with poor overall survival. Moreover, ectopic expression of GIHCG enhanced TSCC cell cycle, proliferation, and migration. Elevated expression of GIHCG inhibited the miR-429 expression in TSCC cells. We demonstrated that the expression level of miR-429 was lower in TSCC tissues and cell lines. Low miR-429 expression was positively associated with poor overall survival. We then determined the correlation between miR-429 and GIHCG expression levels. A statistically significantly inverse correlation was observed between miR-429 and GIHCG expression levels in TSCC tissues. In addition, overexpression of miR-429 suppressed the TSCC cell cycle, proliferation, and migration. Elevated expression of GIHCG promoted TSCC cell cycle, proliferation, and migration through regulating miR-429 expression. These results suggested that GIHCG increased TSCC progression through negative modulation of miR-429. Our results suggested that GIHCG/miR-429 might play a vital role in TSCC progression.

World Workshop on Oral Medicine VII: Clinical evidence of differential expression of lncRNAs in oral squamous cell carcinoma: A scoping review

“…Univariate Kaplan–Meier analyses also found the expression of several other lncRNAs to be positively correlated with poorer survival in OSCC including MALAT1 ( p < 0.05, 54 patients) (Zhou et al., ), NEAT1 ( p = 0.042, 58 patients and p = 0.01, 30 patients) (Huang, He, et al., ; Liu, Shang et al., ), LINC00668 ( p < 0.05, 50 patients) (Zhang, ), FTH1P3 ( p = 0.0032, 70 patients) (Zhang, ), CCAT2 ( p = 0.028, 62 patients) (Ma et al., ), PDIA3P ( p = 0.0211, 58 patients) (Sun et al., ) and ANRIL ( p = 0.013, 130 patients) (Chai, Yuan, Chen, Zhou, & Wu, ). When analysing only TSCC patients, higher expression associated with poor OS was found for GIHCG ( p < 0.05 from a 20 patients cohort) (Ma, Wang, Gong, Xue, & Zuo, ). Conversely, an underexpression of PTENp1 ( p = 0.04, 62 patients) (Gao et al., ) and LINC01133 ( p = 0.013, 50 patients) (Kong et al., ) correlated with a reduced survival rate.…”

<p>Overexpression of <em>GIHCG</em> is Associated with a Poor Prognosis and Immune Infiltration in Hepatocellular Carcinoma</p>

“…13 In addition, GIHCG has been reported to be overexpressed in and promote tumor progression of renal cell carcinoma, tongue squamous cell carcinoma, ovarian cancer, cervical cancer, breast cancer, colorectal cancer and gastric cancer. [14][15][16][17][18][19][20][21] We hypothesized that GIHCG may act as an oncogene during tumorigenesis, however the prognostic value of GIHCG and its possible biological functions in HCC have yet to be fully assessed. Our study aims to assess the prognostic value of GIHCG in both the public HCC database and our clinical HCC cohort and to explore potential pathway correlations with GIHCG expression.…”

Long non‑coding RNA PRNCR1 exerts oncogenic effects in�tongue squamous cell carcinoma in�vitro and in�vivo by sponging microRNA‑944 and thereby increasing HOXB5�expression

“…They are implicated in the modulation of gene expression at the pre-transcriptional, transcriptional and post-transcriptional levels (10). A change in lncRNA expression has been identified in a variety of human cancer types, including gastric cancer (11), thyroid cancer (12), hepatocellular carcinoma (13) and TScc (14). Regarding TScc, recent studies have indicated that numerous lncRNAs are abnormally expressed in this type of tumor and act as either tumor-suppressors or oncogenic RNAs (15,16).…”