Long Noncoding RNA LINC00092 Acts in Cancer-Associated Fibroblasts to Drive Glycolysis and Progression of Ovarian Cancer

Zhao, Linjie; Ji, Gaili; Le, Xiaobing; Wang, Chenlu; Xu, Lian; Feng, Min; Zhang, Yaguang; Yang, Huiliang; Yao, Xuan; Yang, Yanfei; Luo, Lei; Yang, Qilian; Lau, Wayne Bond; Lau, Bonnie; Chen, Yi; Deng, Xiangbing; Yao, Su; Yi, Tao; Zhao, Xia; Wei, Yuquan; Zhou, Shengtao

doi:10.1158/0008-5472.can-16-1615

Cited by 199 publications

(160 citation statements)

References 34 publications

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“…Another study indicated that colorectal neoplasia differentially expressed ( CRNDE ) nuclear transcripts upregulated in colorectal cancer were involved in the regulation of cell metabolism [45]. Zhao et al reported that LINC00092 promoted metastasis by altering glycolysis and sustaining the local supportive function of cancer-associated fibroblasts (CAFs) through binding to glycolytic enzyme-the fructose-2,6-biphosphatase PFKFB2 [46]. Knockdown lncRNA ceruloplasmin (NRCP) could significantly decrease glycolysis and increases mitochondrial respiration in ovarian cancer cells [47].…”

Section: Discussionmentioning

confidence: 99%

High expression of long non-coding RNA MALAT1 in breast cancer is associated with poor relapse-free survival

Wang

Katsaros²,

Biglia³

et al. 2018

Breast Cancer Res Treat

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Section: Discussionmentioning

confidence: 99%

High expression of long non-coding RNA MALAT1 in breast cancer is associated with poor relapse-free survival

Wang

Katsaros²,

Biglia³

et al. 2018

Breast Cancer Res Treat

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“…It inhibits one of the glycolytic enzymes, fructose-2,6-bisphosphatase (PFKFB2), thereby altering glycolysis, which in turn promotes metastasis and sustains the local supportive function of cancer-associated fibroblasts (CAFs) [47–50] (Fig. 1).…”

Section: Lncrnas Regulate Enzymes Regulatory Molecules and Oncogenementioning

confidence: 99%

Role of long non-coding RNAs in glucose metabolism in cancer

et al. 2017

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Long-noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their action is highly complex. Mounting evidence shows that lncRNAs can regulate cancer onset and progression in a variety of ways. They can not only regulate cancer cell proliferation, differentiation, invasion and metastasis, but can also regulate glucose metabolism in cancer cells through different ways, such as by directly regulating the glycolytic enzymes and glucose transporters (GLUTs), or indirectly modulating the signaling pathways. In this review, we summarized the role of lncRNAs in regulating glucose metabolism in cancer, which will help understand better the pathogenesis of malignant tumors. The understanding of the role of lncRNAs in glucose metabolism may help provide new therapeutic targets and novel diagnostic and prognosis markers for human cancer.

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“…As indicated in Fig. 1B, the glycolysis-regulatory molecules, fructose-2 and 6-biphosphatase (PFKFB2), bind to the binding site of LINC00092, leading to a reciprocal regulatory loop with CAFs by controlling glycolytic products to maintain the tumor environment and subsequently cancer metastasis [40].…”

Section: Involvement Of Lncrnas In Ocmentioning

confidence: 99%

Long Non-Coding RNAs: the New Horizon of Gene Regulation in Ovarian Cancer

Worku

Bhattarai

Ayers

et al. 2017

Cell Physiol Biochem

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Long non-coding RNAs (lncRNAs), a class of non-coding transcripts, have recently been emerging with heterogeneous molecular actions, adding a new layer of complexity to generegulation networks in tumorigenesis. LncRNAs are considered important factors in several ovarian cancer histotypes, although few have been identified and characterized. Owing to their complexity and the lack of adapted molecular technology, the roles of most lncRNAs remain mysterious. Some lncRNAs have been reported to play functional roles in ovarian cancer and can be used as classifiers for personalized medicine. The intrinsic features of lncRNAs govern their various molecular mechanisms and provide a wide range of platforms to design different therapeutic strategies for treating cancer at a particular stage. Although we are only beginning to understand the functions of lncRNAs and their interactions with microRNAs (miRNAs) and proteins, the expanding literature indicates that lncRNA-miRNA interactions could be useful biomarkers and therapeutic targets for ovarian cancer. In this review, we discuss the genetic variants of lncRNAs, heterogeneous mechanisms of actions of lncRNAs in ovarian cancer tumorigenesis, and drug resistance. We also highlight the recent developments in using lncRNAs as potential prognostic and diagnostic biomarkers. Lastly, we discuss potential approaches for linking lncRNAs to future gene therapies, and highlight future directions in the field of ovarian cancer research.

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Long Noncoding RNA LINC00092 Acts in Cancer-Associated Fibroblasts to Drive Glycolysis and Progression of Ovarian Cancer

Cited by 199 publications

References 34 publications

High expression of long non-coding RNA MALAT1 in breast cancer is associated with poor relapse-free survival

High expression of long non-coding RNA MALAT1 in breast cancer is associated with poor relapse-free survival

Role of long non-coding RNAs in glucose metabolism in cancer

Long Non-Coding RNAs: the New Horizon of Gene Regulation in Ovarian Cancer

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