Long Noncoding RNA LINC01614 is a Diagnostic and Prognostic Marker for Breast Cancer

Abstract

Background: The long intergenic non-coding RNA 01614 (LINC01614) is aberrantly expressed in various malignancies, suggesting its role in oncogenesis. However, it has not been well studied in breast cancer. Methods: The cancer genome atlas databases (TCGA) and public database of breast cancer gene-expression miner (bc-GenExMiner) were utilized to analyze the prognostic role of LINC01614 in breast cancer. Kaplan-Meier, and Cox regression analyses were conducted for survival analysis. Nomograms were built to predict survival. We used deconvolution-based methods, such as TIMER (Tumor Immune Estimation Resource) and CIBERSORT (cell-type identification by estimating relative subsets of RNA transcripts), to explore the relationship between LINC01614 and immune cell characteristics. Results: The very abnormal expression of LINC01614 was found in 14 types of malignancy, including breast cancer. The LINC01614 was significantly overexpressed in human epidermal growth factor receptor 2 (HER2)+, estrogen receptor (ER)+, progesterone receptor (PR)+, and non-triple negative breast cancer (non-TNBC). According to survival analysis, the higher expression of LINC01614 was related with poor survival. The co-expressed genes analysis exhibited that LINC01614 was closely associated with the collagen-associated process and phosphoinositide 3-kinases-protein kinase B (PI3K-Akt) signaling pathway. Moreover, this study has explored the association among LINC01614 expression, tumor-infiltrating immune cells, and the efficacy of chemotherapeutics. Conclusions: Our data reveal the expression pattern of LINC01614 in breast carcinoma with different molecular subtypes. The results also indicated that the LINC01614 could be a novel diagnostic and prognostic marker for breast carcinoma.

LINC01614 is a promising diagnostic and prognostic marker in HNSC linked to the tumor microenvironment and oncogenic function

“…Knockdown of LINC01614 inhibited cell growth, migration, and invasion of THCA and esophageal squamous cell carcinoma ( Wei et al, 2023 ). In BRCA, LINC01614 as a hazard prognosis factor was associated with the HR+/HER2 + molecular subtype ( Li et al, 2023 ). In osteosarcoma, LINC01614 as a ceRNA promoted tumor progression through the miR-520a-3p/SNX3 axis ( Cai et al, 2021 ).…”

SPACA6P-AS: a trailblazer in breast cancer pathobiology and therapeutics

“…LncRNA research has become a focus in oncology (Cervena et al 2022 ; He et al 2024 ), with these molecules implicated in various mechanisms of tumor initiation and progression, such as gene transcription regulation, mRNA stability and translation, cell cycle, and apoptosis (Shaath et al 2022 ; Li and Wang 2023 ; Liu et al 2022 ). In BC, abnormal expression of specific lncRNAs correlates with tumor cell proliferation, migration, and invasion (Li et al 2023 ), highlighting their potential as new therapeutic targets or prognostic markers (Tan et al 2021 ; Park et al 2021 ; Liu et al 2021 ; Hashemi et al 2022 ).…”