2024
DOI: 10.3390/ijms25105507
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Long Noncoding RNA MALAT1: Salt-Sensitive Hypertension

Mohd Mabood Khan,
Annet Kirabo

Abstract: Hypertension stands as the leading global cause of mortality, affecting one billion individuals and serving as a crucial risk indicator for cardiovascular morbidity and mortality. Elevated salt intake triggers inflammation and hypertension by activating antigen-presenting cells (APCs). We found that one of the primary reasons behind this pro-inflammatory response is the epithelial sodium channel (ENaC), responsible for transporting sodium ions into APCs and the activation of NADPH oxidase, leading to increased… Show more

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